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NAMHC Concept Clearances

Approved Concepts for Requests for Applications (RFAs), Program Announcements (PAs), and Requests for Proposals (RFPs)

Specific information on each initiative, including receipt date, will be available once the RFA, PA, or RFP has been published. This page provides links to recently cleared concepts for upcoming solicitations and presents key information, including the objectives and descriptions of future solicitations and a direct link to NIMH staff contacts. The NIMH staff contacts can provide additional information on specific concepts, where available and appropriate.

This listing of potential future initiatives is meant to provide the earliest possible alert to potential applicants in order to maximize application preparation time. While the NIMH plans to proceed with these initiatives, their publication and timing is not certain and depends on sufficient funds being available. The titles and brief descriptions are consistent with the information available at the time of concept clearance. The resultant RFAs, PAs, RFPs may differ from the concepts in the final wording of the titles or other aspects.

The NAMHC conducts most, but not all, NIMH concept clearances. Concepts may also be cleared through other public venues.

For more information, see the NIH Guide’s  list of published   RFAs  and   PAs  and NIMH Contracts.

Submit comments to Tracy Waldeck at waldeckt@mail.nih.gov.

Concepts

Phenotypic Manifestations of Rare Variations Associated with Neurodevelopmental Disorders

The goal of this initiative is to estimate population prevalence of rare variants associated with neurodevelopmental disorders using very large, unselected populations (epidemiologic cohorts), and conduct in-depth clinical assessments of variant carriers to determine penetrance, range of associated phenotypes, and genotype-by-environment interactions.

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First-Generation RDoC Standard Data Elements

This initiative aims to develop and implement an operational template for including standard data elements in Research Domain Criteria (RDoC)-themed research, and produce an initial set of recommended, provisional standard data elements.

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Development of a BrainSpan RNA-seq Browser

This initiative aims to create an RNA-seq web browser for the data contained in the BrainSpan Atlas, an NIMH-funded project that provides a comprehensive atlas of human brain development including high resolution images and RNA sequence data.

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Toward Early Prediction of Psychosis: Collaborative Research on Developmental Risk in 22q11.2 Deletion Syndrome

This initiative aims to support a collaborative, multi-site, prospective longitudinal study to track neurodevelopmental trajectories and to collect biomarkers in children and adolescents at high risk for psychosis by virtue of having 22q11.2 deletion syndrome (DS).

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Secondary Data Analyses to Explore RDoC Domains

This initiative aims to support secondary analyses of existing datasets, by leveraging clinical research data to investigate specific domains within the Research Domain Criteria (RDoC) project or test novel hypotheses that are consistent with RDoC.

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Post-Traumatic Stress Disorder: Heterogeneity and Translation

NIMH is proposing multiple efforts to address the challenges of heterogeneity and translation in post-traumatic stress conditions. This initiative involves two related but distinct components: to interrogate mechanisms responsible for subtypes of impairment in small scale translational experiments; and to acquire longitudinal and dimensional data on emergence and course of post-traumatic clinical phenomena to enhance early prediction and classification of conditions and identify targets for prevention.

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Imaging Data and Biomarkers

The key goal of this initiative is to find imaging biomarkers related to mental illness or the heterogeneity within diagnostic groups. Two different approaches are proposed: add data from subjects with mental illness to the Human Connectome Project and explore the most effective ways to use existing images and image repositories.

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Services Research for Autism Spectrum Disorder across the Lifespan (ServASD)

The goal of this initiative is to support research to develop and test the effectiveness of services strategies to improve functional outcomes and quality of life for people with autism spectrum disorder (ASD) at three key life stages: early childhood, transition from youth to adulthood, and adulthood.

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Improving Health and Reducing Premature Mortality in People with Severe Mental Illness

The goal of this initiative is to support research on service interventions that demonstrably reduce the prevalence and magnitude of modifiable health risk factors related to shortened lifespan in people with severe mental illness (SMI).

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Building an Evidence-Based Response to Disaster and Mass Trauma Events

This initiative seeks to leverage the existing disaster response infrastructure and workforce to integrate evidence-based and promising interventions into current mental health response. Partnership between researchers and disaster response providers will enable the field to plan, in advance of large scale emergencies, rigorous intervention and services research studies to improve care for new and complex mental health needs in the wake of disasters.

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Ascertaining Critical Transitions in Eating Disorders

The initiative aims to support research that will advance our understanding of the biological mechanisms underlying eating disorders by studying periods of transition.

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Cognitive Training Resource Exchange (CogTRex)

This initiative aims to create an online sharing site for researchers who are developing and testing the efficacy of cognitive training (CT) interventions for mental disorders. The CogTREx website would promote sharing of resources and information across disciplines and among researchers, addressing a range of mental disorders in children and adults. CogTREx aims to accelerate intervention development through early sharing of successes and failures, to promote rigorous clinical trial design, and to promote interaction across disciplines and disorders.

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Emergency Department Suicide Prevention in Youth

Suicide continues to be the third leading cause of death among youth aged 10-24 years old. Emergency Medicine Department (ED) practitioners are responsible for risk assessment, discharge, and referral of high risk suicidal individuals, yet no evidence-based standards exist for these practices. This initiative aims to support research to improve identification, evaluation, and appropriate referral by ED staff of youth at risk for suicide. This research will lay the foundation for future efforts to match appropriate interventions to at-risk youth, increasing intervention effectiveness and improving long-term clinical outcomes.

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Leveraging ARRA Resources to Accelerate Research on Neurodevelopment

This initiative aims to stimulate the broader research community to utilize NIMH resources funded by the American Recovery and Reinvestment Act of 2009 (ARRA) to develop and evaluate hypotheses about the combined and interactive influences of genetics, brain maturation, neurocognitive function, and environment during development.

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Gut Microbiome-Brain Interactions in Mental Health: Implications for Mental Disorders

The purpose of this initiative is to encourage hypothesis-driven research by multidisciplinary teams of investigators that will investigate mechanisms by which the gut microbiota modulate pre- and postnatal neurodevelopment, brain function, and behavioral domains relevant to the mission of NIMH. Such fundamental research may suggest avenues for future translational research.

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PsycENCODE: Exploring the Function of Non-coding Elements in the Brain

This initiative aims to support studies on mental disorders based on new concepts of transcriptome complexity that assign functional roles to non-coding and potentially novel coding transcripts, exploring their potential as trans-regulators of gene transcription, mRNA splicing, mRNA stability, molecular transport, and influence on chromosome architecture.

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Using Collaborative Care to Reduce Racial and Ethnic Disparities in Mental Health Care

This initiative aims to support innovative research on the implementation of evidence-based interventions to reduce disparities in mental health care among diverse racial and ethnic groups in the United States. The research supported will contribute to the reduction of disparities in access to care, retention in care, and treatment outcomes.

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Building the Next Generation of Global Mental Health Researchers

The purpose of this initiative is to support the career development and training of outstanding early career mental health researchers interested in pursuing global mental health research careers.

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Increasing the Use of the National Database for Autism Research (NDAR)

The purpose of this initiative is to encourage researchers to use the data in the National Database for Autism Research (NDAR) to reproduce and extend published data, validate hypotheses generated during experiments performed on small samples, and generate new findings and hypotheses.

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New Experimental Medicine Studies: Fast-Fail Trials (FAST)

This initiative seeks to expeditiously test and analyze novel pharmacological interventions and their molecular and/or clinical targets for treating clinical dimensions of psychopathology associated with traditional psychiatric disorders.

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Development of Tools to Explore the Synaptome

The purpose of this initiative is to encourage applications to develop novel technologies and/or tools to facilitate the study of genes and proteins at the synapse on a large scale.

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National Center for Advancing Translational Sciences (NCATS) Discovering New Therapeutic Uses for Existing Molecules

The NCATS New Therapeutic Uses Program will fund research to identify new therapeutic uses of proprietary investigational drugs and biologics (Agents), made available by participating pharmaceutical partners, to improve healthcare and benefit to patients across a broad range of human diseases in areas of unmet medical need.

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A National Neurobiobank

The goal of the NIH Neurobiobank is to create a centralized biorepository for the acquisition, receipt, storage and dissemination of human brains, related biospecimens, and associated clinical data. The goal is to increase the availability of, and access to, high quality specimens for research to understand the neurological basis of disease, while also increasing efficiency and economy of scale.

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Eradication of HIV-1 from CNS Reservoirs: Implications for Therapeutics

The goal of this initiative is to foster discovery research to define and characterize the sources of HIV-1 persistence in the central nervous system (CNS) for people on suppressive anti-retroviral therapy, and to foster translational research to enable therapeutic eradication of HIV-1 from the brain.

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Harnessing Advanced Health Technologies to Drive Mental Health Improvement

This initiative aims to support research to test the effectiveness of existing health information technologies (IT) to improve access to and quality of mental health care significantly, and improve the collection and use of actionable mental health information.

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Innovative Pilot Studies of Novel Mechanism of Action Compounds

This initiative will support innovative Phase I and Phase IIa studies of compounds of potential neurobiological relevance with novel mechanisms of action. The initiative encourages a broad approach for exploring pharmacological and functional effects of compounds, in the context of standard outcome measures. Such approaches will provide early proof-of-concept testing of clinically relevant neurobiological outcomes, and de-risk promising drug candidates.

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Advancing HIV Prevention through Transformative Behavioral and Social Science Research

This initiative aims to advance generalizable knowledge about HIV prevention through transformative behavioral and social science research. An underlying assumption for this initiative is that methods of and findings from social and behavioral studies can make essential contributions to research which utilizes biomedical modalities. In addition, biomedical perspective is essential for the advancement of social and behavioral HIV research on prevention.

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Astrocyte Heterogeneity, Development and Function in Brain Regions Relevant to Mental Illness

This initiative will support discovery research on astrocyte diversity and function, adaptation of new technologies to astrocyte research, and the application of these to the study of brain processes relevant to mental illness.

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Neural Mechanisms Underlying Sex Differences in Risk and Resilience for Mental Illness

The purpose of this initiative is to support basic and translational research on the neurobiology of sex differences in order to expand our understanding of the etiology and developmental trajectories of mental disorders in males and females, and to inform novel approaches to individualized interventions and treatment across the lifespan.

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Creating Diversity and Leadership in the Next Generation of Mental Health Researchers

This initiative aims to support the career development and training of outstanding early career mental health researchers from diverse backgrounds who are currently underrepresented in neuroscience, biomedical, and behavioral sciences.

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Determinants and Mechanisms of Prevalence Patterns of Common Mental Disorders in Diverse Populations

To stimulate research on the determinants and mechanisms over the life course that produce variation in the prevalence of common mental disorders (CMD) across diverse populations.

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Dimensional Approaches to Research Classification

The purpose of this initiative is to support translational grants that investigate mechanisms of mental disorders through classification of patient participants employing circuit-based dimensions of functioning rather than traditional disorder categories.

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Grand Challenges in Global Mental Health

This initiative aims to support innovative research that will generate the major scientific advances needed to make a significant impact on the lives of people living with neuropsychiatric disorders worldwide. The research supported will address barriers that, if removed, will have a significant impact on the prevention and treatment of mental disorders worldwide.

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Integrating Multi-Dimensional Data to Explore Mechanisms Underlying Psychiatric Phenotypes

This initiative will support development of advanced bioinformatics and statistical tools to integrate genomic, environmental, and phenomic data to link various complex phenotypes leading to novel diagnostic tools, clinical trials, and potential targets for intervention in mental disorders.

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Optimizing Fidelity of Empirically Supported Behavioral Treatments for Mental Disorders

his initiative aims to support research that will enhance the fidelity, and ultimately the effectiveness, of empirically supported behavioral treatments (ESBT) for mental disorders as implemented by community-based therapists. More specifically, it encourages research designed to develop and test: (a) methods for assessing theory-derived ESBT fidelity components; and (b) interventions that enhance and maintain the fidelity with which clinicians implement these ESBTs in community settings.

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Pathophysiology of HIV-Associated Neurodegeneration in Aging Populations on Long-term Anti-Retroviral Therapy

This initiative will support research on elucidating mechanisms of neuropathogenesis of HIV-Associated Neurocognitive Disorders (HAND) in the aging population, in the setting of long-term treatment and associated neurodegenerative diseases and co-morbid conditions.

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Promoting Engagement in Care and Timely Antiretroviral Initiation Following HIV Diagnosis

The overarching aims of this initiative are to develop and test interventions to reduce the time between HIV diagnosis and achievement of first undetectable viral load among patients for whom antiretroviral therapy (ART) is indicated, as well as to reduce racial and ethnic disparities in HIV-treatment outcomes.

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Translational Research for the Development of Novel Interventions for Mental Disorders

This initiative solicits grant applications to speed the translation of emerging findings on the neuroscience of mental disorders into novel treatment approaches that will ultimately alter dysfunctional neural circuits and psychological processes underlying mental disorders.

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Collaborative Studies of Neurodevelopmental Trajectories in Children at Familial Risk for Schizophrenia or Bipolar Disorder

This initiative solicits collaborative research applications to conduct a coordinated, multi-site, multi-modal longitudinal study charting middle-childhood (ages 6–12 years) trajectories of brain, cognitive, and affective development among those at high and low familial risk for schizophrenia or bipolar disorder, before the onset of prodromal symptoms. 

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Improving Evidence-Based Mental Health Screening and Treatment for Persons with Mental Disorders in the Justice System

This initiative solicits research to investigate the effectiveness of both new and existing strategies for the delivery of mental health treatments in criminal (adult) or juvenile justice settings. Settings of interest include: 1) incarceration or detention; 2) community corrections (parole and probation); and, 3) programs to facilitate transition to community.

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Reinvigorating HIV Prevention for Men who have Sex with Men

The goal of this initiative is to facilitate the development and testing of new, efficacious HIV prevention interventions, which, if scaled-up and implemented, will help to curb incident HIV infections, reduce HIV-associated morbidity and mortality, and reduce health disparities in HIV among men who have sex with men (MSM).

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New, Rapidly-Acting Treatments for Treatment-Resistant Depression (RAPID)

This initiative will promote the development of rapid treatments (within less than 48 hours of administration) for severe, treatment-resistant depression.

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Behavioral Mechanisms in Biomedical Strategies to Prevent HIV Infections

This initiative will advance understanding of the complex behaviors pertinent to the range of promising new biomedical strategies for averting HIV infections, including pre-exposure prophylaxis (PrEP), microbicides, male circumcision, and others.

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Epigenomic Modifications in Neurodevelopment

This initiative solicits research to identify the developmental and tissue specific targets of epigenetic regulation resulting from environmental and social stimuli and to identify the components of the signaling pathway(s) that link stimuli to gene regulation and subsequent phenotypic variability.

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Unbiased in vitro Analysis of Neurobiological Function

This initiative will support the use of neurobiological assays in the development of robust analytical platforms that could be used to reveal changes in neuronal function, with the intent to move basic neuroscience discoveries into translational applications. The novel assay platforms would provide opportunities to measure neurobiological endpoints, and build a pipeline to be used in the context of target identification and drug discovery.

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Competitive Supplements for Targeted Research on Mental Health Disparities

This initiative will stimulate research that uses existing data sources to increase knowledge in three areas of mental health disparity research: identification of differences in engagement, outcomes, or mediators for health disparity populations in clinical trials; epidemiology of cardiovascular disease (CVD) risk factors among health disparity populations with serious mental illness (SMI); and methodologies for measuring and tracking mental health disparities.

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Regional Mental Health Networks in Low- and Middle-Income Countries

To establish regional centers for coordinated mental health research and research capacity-building in low- and middle-income countries.

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A Repository to Support NIMH-Relevant Patient-Derived Stem Cell Research

This initiative will establish a repository/bank for control and patient-derived primary cells and their reprogrammed derivatives, such as induced pluripotent stem cells (iPSCs), to support stem cell research relevant to NIMH-aligned disorders.

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NIH Blueprint for Neuroscience Research RFA: The Human Connectome Project

The goal of the five year Human Connectome Project (HCP) is to develop and share knowledge about the structural and functional connectivity of the human brain.

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Building a Longitudinal Mental Health Tracking System

Building a Longitudinal Mental Health Tracking System: This initiative will leverage the power of existing household surveys on behavioral health by embedding detailed modules assessing psychopathology, functioning, and service use.

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Research on Biomarkers for Mental Disorders

Research on Biomarkers for Mental Disorders Concept Clearances - This initiative will solicit applications proposing novel approaches to the identification, characterization, and validation of biomarkers and/or biosignatures (integrated profiles of biomarkers and behavioral indicators) of major mental disorders.

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Identification and Characterization of Sensitive Periods for Neurodevelopment of Mental Illness

Identification and Characterization of Sensitive Periods for Neurodevelopment of Mental Illness Concept Clearances - This initiative will stimulate neurodevelopmental research in humans and animals that will increase our understanding of the neurobiology underlying developmentally sensitive periods for risk, resilience, and intervention.

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Exploratory Studies of Induced Pluripotent Stem (iPS) Cells from Healthy and Patient Populations

This initiative will support exploratory studies to generate and characterize induced pluripotent stem (iPS) cells from healthy and/or patient populations.

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Leveraging Health Care Networks to Transform Effectiveness Research

This initiative will stimulate research that will demonstrate the linking of existing health care databases to show feasibility of conducting effectiveness trials within existing networks.

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Viral and Host Genetic Factors Regulating HIV-Associated CNS Disease

This initiative will support research on viral and host genetic factors regulating susceptibility to and progression of HIV-associated neurologic and neuropsychiatric disease.

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The GEI Systems Biology Initiative

This initiative will provide support for investigators to conduct studies in systems biology that expand on previous findings from Genome Wide Association Studies (GWAS) to identify and characterize the molecular elements of the larger dynamic networks and their perturbations underlying complex human disease states.

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Suicide Prevention Efforts in Emergency Medicine Departments

Emergency Medicine Department (ED) practitioners are responsible for appropriate risk assessment, discharge, and referral of high risk suicidal individuals, yet no evidence based standards exist for these practices. This initiative supports research to improve identification, evaluation, and appropriate referral by ED staff of individuals at risk for suicide, as well as research to develop practical interventions that can assist community providers who care for these high-risk patients.

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Promoting Outstanding Mental Health Innovators in Scientific Excellence (PrOMISE) Awards

The Promoting Outstanding Mental Health Innovators in Scientific Excellence (PrOMISE) Award is intended to identify outstanding scientists who are in the early, formative stages of their careers and who intend to make a long-term career commitment to research in the mission areas of NIMH. This award would assist the investigators in launching an innovative research program that holds the potential to profoundly transform the understanding of diagnosis, treatment, and prevention of mental disorders, paving the way for a cure.

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Home-Based Lithium Level Testing for Bipolar Patients

The goal of this initiative will be to assess the feasibility of a home-based lithium level test.

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Comparative Studies of Cortical Development to Link Developmental Neuroscience and Behavior

This initiative will support studies that link behavioral and cortical neurodevelopmental processes across species.

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Clinical Pharmacotherapy for Posttraumatic Stress Disorder (PTSD)

This initiative will advance research on the efficacy of available and exploratory medications for PTSD.

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Addressing the Mental Health Needs of Returning Combat Veterans in the Community

This initiative will systematically evaluate the impact of community-based “reintegration” programs on the mental health and behavioral adjustment of National Guard, Reserve Component, and newly separated combat veterans from Operation Iraqi Freedom and Operation Enduring Freedom.

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Recovery After an Initial Schizophrenic Episode (RAISE)

The goal of this initiative is to improve prognosis and long-term outcome for people suffering from schizophrenia.

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Novel NeuroAIDS Therapies: Integrative Preclinical/Clinical Program (IPCP)

This initiative will support novel bench-to-bedside research in NeuroAIDS treatment development. We propose to foster the Novel NeuroAIDS Therapies: IPCP to support new treatment concepts that can be integrated into clinical practice and open new research directions.

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Novel Interventions for Neurodevelopmental Disorders

This initiative will support the development of novel interventions for neurodevelopmental disorders, with the aim of improving various domains of functioning that are impaired across disorders, and of altering developmental trajectories

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Networks for Developing PTSD Risk Assessment Tools

This initiative will support the development and initial testing of new approaches to differentiate trauma survivors who will recover naturally from those who will develop enduring symptoms and Post-Traumatic Stress Disorder (PTSD).

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Limited Competition for Data Deposition and Analysis of Genomic Wide Association Studies of Mental Disorders

This initiative will support applications that propose to deposit data (genotypes and phenotypes) into an NIH Repository to augment existing resources and to analyze combined Genome Wide Association Studies (GWAS) of mental disorders of interest to the NIMH.

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Genomic Parsing of Bipolar Disorder and Schizophrenia: Studies of Large Cohorts in the U.S. and Across the Globe

This initiative will support the collection of large cohorts of patients with bipolar disorder or schizophrenia to enrich pre-existing resources in the NIMH Genetics Repository and apply genomic research paradigms to further our understanding of the molecular etiology of these disorders.

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Programs of Excellence in Scientifically Validated Psychosocial Treatment

This initiative will support curriculum development to train clinician-scientists who can develop, test, and translate into practice innovative psychosocial treatments for addictive and mental disorders. The goals are to recognize and enhance current clinical training programs that teach and develop research-based clinical practices, and to provide a model for clinician education nationwide.

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NIMH Career Opportunities in Research (COR) Honors Undergraduate Research Training Grant (T34)

The NIMH Career Opportunities in Research (COR) supports undergraduate research training to develop a pool of individuals who will help ensure that a diverse and highly trained workforce is available to assume leadership roles related to the Nation’s biomedical, behavioral and clinical research agenda for mental health.

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Developing State Mental Health Services Research “Laboratories” for Policy Relevant Studies

This initiative will stimulate collaborative state, agency, and academic research projects that use existing state data to address policy issues relevant to state or regional public mental health services.

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Developing Innovative Approaches to Personalizing Mental Health Care

The purpose of this initiative is to support innovative approaches to designing and testing personalized treatment in mental health practice.

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Adapting Basic Cognitive Measures for Clinical Assessment of Schizophrenia

This initiative will support the development of new cognitive assessment measures for schizophrenia that are based on experimental cognitive science paradigms, in contrast to traditional clinical neuropsychological methods.

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Novel Methods for Examining Prefrontal Interactions with Cortical and Subcortical Systems that Support Complex Mental Function

To stimulate research on how prefrontal cortical regions interact with other cortical and subcortical systems to give rise to sophisticated behavior and cognitive function using state-of-the-art electrophysiological and molecular techniques.

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Mouse Models Containing Human Alleles: Novel Tools to Study Brain Function

This initiative will support the development and characterization of novel mouse models that express human genes or human genetic elements that can aid in understanding the molecular mechanisms underlying brain function relevant to the research priorities of NIMH.

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National NeuroAIDS Tissue Consortium

The Center for Mental Health Research on AIDS has designed this initiative to solicit two application types: (1) competing continuation applications to support the clinical assessments and banking of tissues and fluids at the National NeuroAIDS Tissue Consortium (NNTC) sites; and (2) new applications to support a single associated database center referred to as the National Coordination Office (NCO). The initiative represents a reorganization of the existing multi-site brain bank structures that will incorporate a cohort-based scientific agenda into the ongoing functions of the consortium.

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Limited Supplementary Funding for Whole Genome Association Studies

The purpose of this initiative is to provide supplementary funding to enhance comprehensive analyses of whole genome association (WGA) data.

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Large Scale Sequence Data Analysis for Complex Disorders

This initiative will encourage the development of novel methods in computational biology and population genetics that take into account multiple testing, as applied to large scale mutation-detection.

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Center for Genomic and Phenomic Studies in Autism

This initiative will comprehensively characterize a large sample of autistic children and their relatives, both cytogenetically and phenotypically, including potential biomarkers and other endophenotypes, with the goal of capturing the autism phenome.

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AIDS Mental Health Centers (AMHC) at RCMI-Eligible Institutions

The overall goal of this initiative is to develop HIV/AIDS mental health research (i.e., AIDS Mental Health Centers, AMHC) at the National Center for Research Resources (NCRR)-supported Research Centers for Minority Institutions (RCMIs).

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Translational Research on the Relationship Between Anxiety and Depression

Several lines of evidence point to a relationship between anxiety and depression, but it is not well understood. This proposed initiative on the relationship between these disorders is intended to provide data for translation into experimental preventive or treatment interventions for anxiety and depression.

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Mechanisms of HIV Neuropathogenesis: Emerging Domestic and Global Issues

As treatment with HAART (highly active anti-retroviral therapy) enables people with HIV to live longer, the nature of associated central nervous system (CNS) disease is changing; for example, frequency of milder, more chronic forms is rising.

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Interventions and Service Delivery Models for Youth Transitioning to Adulthood

The intent of this proposed initiative is to address gaps in intervention and service delivery for youth in the period of transition to adulthood. Disorder-specific, evidence-based treatments and traditional acute-care treatment models often are inadequate for achieving optimal outcomes and functioning for people in this age range.

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Mental Health Issues in Basic and Translational Social Neuroscience

Social neuroscience is a rapidly emerging new discipline. Over the past several years, there has been an increase in the number of satellite symposia in this area at organizations such as the Cognitive Neuroscience Society and a greater focus in the scientific literature.

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Implicating Noncoding RNAs in the Genetics of Mental Disorders

Noncoding RNAs are surprisingly prevalent in the human genome and may play a critical role in the regulation of gene expression.

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Treatment Response: Linking Genes with Behavioral Phenotypes of Relevance to Patients, Families, and Policymakers

Now that new tools (e.g., high throughput genotyping and array technology) make it possible to ask if we can determine the complex genetic basis of mental disorders, how shall we decide what are the relevant phenotypes? Articles about the genetic basis of mental illness continue to use DSM categories.

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