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Posts about Basic Research

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From My Data to Mined Data

Dr. Insel discusses the importance of data sharing within the scientific community and highlights how NIMH is encouraging this process.

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Manipulating Memory

Neurotechnologies are making it possible to finely tune brain circuitry to manipulate memory.

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Autism Awareness: April 2014

Dr. Insel describes new scientific findings on autism, including new CDC prevalence data, being reported just as Autism Awareness Month begins.

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Brain Awareness

In a blog about Brain Awareness Month, NIMH Director Thomas Insel talks about the complexity of the brain and challenges ahead for research to understand it.

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Ten Best of 2013

Dr. Insel reviews his “top ten” selections for 2013, including research advances and historic policy changes affecting mental health care.

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P4C : Time = Lives

Dr. Insel recaps the annual Partners for Cure (P4C) meeting, where the theme is to speed the delivery of new cures through innovative research models.

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One Person, Many Genomes

The discovery that mutations unique to an individual are common in the brain changes, and complicates, the search for genes underlying brain disorders.

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In Vitro Veritas?

With more than 100 common gene variants recently implicated in schizophrenia and autism, the problem now is to pinpoint how they might change brain circuits. A promising new tool is a sort of budding brain in a dish. What’s amazing – eclipsing earlier “disease-in-a-dish” discoveries – is that, over weeks and months, differentiating cells in these “organoids” organize themselves according to the architecture that we see in a functioning human brain.

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Accessing and Assessing Science: From PLOS to DORA

In his blog, Dr. Insel discusses the challenge of assessing the quality of scientific research in a new era of open access publishing.

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Infantile Amnesia

Dr. Insel describes how insights from research into why we do not retain memories from the first four years of life may help shed light on many aspects of memory.

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A Sampling of Summer Science

Dr. Insel reports in his blog about intriguing findings published this summer on the genes and disruptions in brain circuitry involved in schizophrenia.

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Getting Serious About Mental Illnesses

Dr. Insel explains the nuances of the term, “serious mental illness.”

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Open Data

Dr. Insel talks about the value of data sharing and collaboration to promote innovation and scientific discovery.

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New Views into the Brain

Dr. Insel talks about how a powerful new brain imaging technique will make it possible for scientists to investigate the brain in in an entirely new way, offering a preview of what scientists hope to achieve with tools developed as a result of the new BRAIN initiative.

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Making the Connection

Dr. Insel’s blog makes the link between neuroscience and the national conversation on mental illness and gun violence; neuroscience research is the key to our being able to identify psychosis risk early and preempt the development of serious mental illness.

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Brain Awareness

In a blog about Brain Awareness Month, NIMH Director Thomas Insel talks about the mysteries that remain to be solved about how the brain works.

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Roads Not Taken

NIMH’s director talks about the need for research that explores the frontiers of science and funding efforts to encourage innovative research.

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A Decade of Perspective

In looking back at ten years as NIMH director, Dr. Insel talks about the importance of rigorous science as the source of new, sometimes surprising, knowledge and ultimately, more effective means of prevention and treatment for mental illness.

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Summer Science

Numerous provocative advances in neuroscience were reported during the summer of 2012.

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Time Matters – Why We Care So Much About Data Sharing

Dr. Insel discusses the dynamics of data sharing in research.

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Research Domain Criteria -- RDoC

The RDoC project is an experimental approach to classification of mental disorders that will serve as a framework for ongoing research.

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An Emerging Era of Big Data

Dr. Insel discusses the emergence of “big data” and how open sharing of data could impact mental health research.

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The Long Paths to Breakthroughs

Dr. Insel talks about how basic research can lead to potential treatments.

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Balancing Immediate Needs with Future Innovation

Dr. Insel responds to discussion from the National Advisory Mental Health Council concerning the need to balance research funding for basic science and mental health services.

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NIMH’s Top 10 Research Advances of 2011

Dr. Insel shares NIMH’s Top 10 Research Advances for 2011.

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Treatment Development: The Past 50 Years

Dr. Insel discusses the state of psychiatric research and development (R&D) in the public and private sectors

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Neuroscience Advances Showcased in Washington

Dr. Insel reflects on an exciting neuroscience conference where an increasing interest in neuropsychiatric disorders was evident.

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Travels Abroad Reveal Impressive Investment in Science

Dr. Insel’s tour to Australia, Singapore, China and Japan reveal heavy investments in science and science education, indicating the time is ripe for collaboration.

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Mental Illness Defined as Disruption in Neural Circuits

Research on neural circuits is changing how mental illnesses are understood and may ultimately lead to new ways to treat brain disorders early enough to prevent symptoms.

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Skin cells to neurons: Disease-in-a-dish promises shortcut to discovery

An emerging research technology using Induced pluripotent stem cells holds promise as a window into the developing brain in mental illness.

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New Findings Reveal New Worlds In Neuroscience

Windows to completely new areas of research have been opened recently by research efforts in basic science. These reports force us to consider factors that have not previously been thought to have any role in mental health or illness.

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NIMH’s Top 10 Research Events and Advances of 2010

10 breakthroughs and events of 2010 which are changing the way we approach mental disorders.

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From Cognition to Genomics: Progress in Schizophrenia Research

This blog outlines recent progress in schizophrenia research, citing a special issue of the journal Nature focusing on schizophrenia.

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Microbes and Mental Illness

Increasing evidence linking strep infection to OCD in children suggests that microbiomics may prove an important research area for understanding and treating mental disorders.

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NIMH’s BRAINS Awards—In Support of Creativity

NIMH recognizes the first seven recipients of its BRAINS awards.

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NIMH Basic Science Support: Busting Myths

NIMH has always and will continue to support cutting edge basic science research. Understanding normal functioning of brain-behavior relationships is critical to providing insight into abnormal brain-behavior relationships. To build a translational bridge we will need a very strong foundation in basic science. This foundation will need to be multidisciplinary and cut across species and levels of analysis.

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