News and Multimedia from 2010 Featuring DNBBS
- $40 Million Awarded to Trace Human Brain’s Connections
- Press Release September 15, 2010
The National Institutes of Health today awarded grants totaling $40 million to map the human brain’s connections in high resolution. Better understanding of such connectivity promises improved diagnosis and treatment of brain disorders.
- Rapid Antidepressant Works by Boosting Brain’s Connections
- Science Update September 09, 2010
An experimental drug that lifts depression in hours likely works by rapidly stimulating connections between brain cells, a study in rats has revealed. The drug, called ketamine, quickly generated such synapses in a brain circuit implicated in human depression by triggering a key enzyme.
- Stress Hormone Receptors Less Adaptive in Female Brain
- Science Update August 09, 2010
A study in rats has revealed striking gender difference in the brain’s stress response that could shed light on women’s proneness to mood and anxiety disorders. Female rat brain cells were more sensitive to a key stress hormone than males’, which could adapt to the hormone in a way female cells couldn’t.
- Mental Decline Thwarted in Aging Rats
- Press Release July 08, 2010
Scientists have discovered a compound that restores the capacity to form new memories in aging rats, likely by improving the survival of newborn neurons in the brain's memory hub. The research, funded in part by the National Institutes of Health, has turned up clues to a neuroprotective mechanism that could lead to a treatment for Alzheimer's disease.
- Drug Substitutes for Training in Rats, Inducing a Memory of Safety
- Press Release June 04, 2010
Researchers have found a way to pharmacologically induce a memory of safety in the brain of rats, mimicking the effect of training. The finding suggests possibilities for new treatments for individuals suffering from anxiety disorders.
- Resilience Factor Low in Depression, Protects Mice From Stress
- Press Release May 17, 2010
Scientists have discovered a mechanism that helps to explain resilience to stress, vulnerability to depression and how antidepressants work. The new findings, in the reward circuit of mouse and human brains, have spurred a high tech dragnet for compounds that boost the action of a key gene regulator there, called deltaFosB. Triggering deltaFosB, which is depleted in post-mortem brains of depressed patients, protected mice from developing a depression-like syndrome following chronic social stress.
- Impaired Brain Connections Traced to Schizophrenia Mutation
- Press Release March 31, 2010
The strongest known recurrent genetic cause of schizophrenia impairs communications between the brain’s decision-making and memory hubs, resulting in working memory deficits, according to a study in mice.
- Same Genes Suspected in Both Depression and Bipolar Illness
- Science Update January 28, 2010
Researchers, for the first time, have pinpointed a genetic hotspot that confers risk for both bipolar disorder and depression. People with either of these mood disorders were significantly more likely to have risk versions of genes at this site than healthy controls. One of the genes, which codes for part of a cell’s machinery that tells genes when to turn on and off, was also found to be over-expressed in the executive hub of bipolar patients’ brains, making it a prime suspect. The results add to mounting evidence that major mental disorders overlap at the molecular level.
- Fear: Replacing Memories
- Video January 04, 2010
The human brain goes through a complex process to form and consolidate memories. But is it possible to replace memories of fearful events, and in doing so, assist in the treatment of patients suffering from the debilitating effects of post-traumatic stress disorder or other anxiety disorders? Dr.Joseph LeDoux and a team of New York University neuroscientists think they have found a way to replace traumatic memories through therapy.
- Behavioral Science and Integrative Neuroscience Research Branch
- Genomics Research Branch
- Molecular, Cellular, and Genomic Neuroscience Research Branch
- Neurotechnology and Molecular Biotechnology Programs
- Office of Research Training and Career Development
- Molecular Libraries and Imaging Roadmap Program
- Small Business Innovation Research and Small Business Technology Transfer Programs