News and Multimedia Featuring DNBBS

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Suppressing Protein May Stem Alzheimer’s Disease Process
Press Release • April 25, 2013
CD33 activity and beta-amyloid

Scientists funded by the National Institutes of Health have discovered a potential strategy for developing treatments to stem the disease process in Alzheimer’s disease, by blocking activity of a little-known regulator protein called CD33.

Dr. Michelle Freund, NIMH Project Officer on the significance of CLARITY
Video • April 11, 2013
Video. Project officer Michelle Freund, Ph.D., of the NIMH Division of Neuroscience and Basic Behavioral Science, explains the significance of CLARITY, a breakthrough method for analyzing the brain.
Fat-free See-through Brain Bares All
Press Release • April 10, 2013
Fat-Free Brain Bares All

Scientists can now study the brain’s finer workings, while preserving its 3-D structure and integrity of its circuitry using a breakthrough method, called CLARITY, that substitutes a clear gel for fat that normally holds the brain’s working components in place, making its normally opaque and impenetrable tissue see-through and permeable.

Developing Male Brain Exposed to Less Stress-Protective Protein
Science Update • March 12, 2013
Dr. Tracy Bale

Why are rates of schizophrenia and autism higher in males? New evidence implicates an enzyme expressed in the placenta that helps protect the developing fetal brain from adverse effects of maternal stress early in pregnancy.

NIMH’s Dr. Aleksandra Vicentic: Sleep Brain Wave Key to Conquering Fear Memories
Science Update • March 08, 2013
Dr. Aleksandra Vicentic

An NIMH-funded research study in rats identifies a specific group of cells in the brainstem whose activation during rapid eye movement (REM) sleep helped in eradicating unwanted memories, paving the way for future therapeutics for these disorders.

Five Major Mental Disorders Share Genetic Roots
Science Update • March 01, 2013
Dr. Bruce Cuthbert, Ph.D.

Five major mental disorders share some of the same genetic risk factors, the largest genome-wide study of its kind has found.

Different Genes, Same Risk Pathway in Schizophrenia
Science Update • January 02, 2013
scientist holding lab mouse.

Work by NIMH-supported scientists illustrates the variability of the genes and biology underlying illnesses like schizophrenia.

Stress-Resilience/Susceptibility Traced to Neurons in Reward Circuit
Press Release • December 12, 2012
Optogenetic stimulation of reward circuit

Researchers, for the first time, have instantly switched depression-like states on-and-off in mice by tweaking the firing pattern of neurons in the brain’s reward circuit.

Switching Off a Specific Brain Region Can Alter Ingrained Habits in Rats
Science Update • November 27, 2012
rat in a maze

Old habits may die hard, but we might be able to turn them off by targeting a specific brain region. Such a discovery could help us find better ways of controlling addiction or certain mental disorders like obsessive compulsive disorder.

In-sync Brain Waves Hold Memory of Objects Just Seen
Press Release • November 01, 2012
blue teddy bear

The brain holds in mind what has just been seen by synchronizing brain waves in a working memory circuit, an animal study suggests. The more in-sync such electrical signals of neurons were in two key hubs of the circuit, the more those cells held the short-term memory of a just-seen object. The new findings may upturn prevailing theories about how working memory works.


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