This program supports research examining genes, gene function, and gene regulatory mechanisms in vertebrate and invertebrate model organisms relevant to understanding the genetic, epigenetic, and genomic components of brain function. This includes studies exploring the genetics of behaviors related to mental health. Areas supported by this program include, but are not limited to:
- Use of model systems to study DNA regulatory elements, cis- and trans-acting factors, critical features of chromatin architecture and relevant mechanisms of gene expression.
- Studies in model systems that examine the transcriptional regulation of gene expression, RNA processing and expression including efforts to understand the role of non-coding RNAs.
- Investigation of post-transcriptional and translational processes and molecular mediators responsible for functional changes within specific populations of brain cells.
- The development and use of novel and existing model systems to understand the regulation and biological function of genes implicated in mental disorders.
This program seeks to support a broad spectrum of investigator initiated projects in vivo and in vitro on basic processes underlying CNS function. Applicants are strongly encouraged to discuss their proposals with the institute contact listed below prior to the submission of their applications to ascertain that their proposed work is aligned with NIMH funding priorities.
Andrea Beckel-Mitchener, Ph.D.
6001 Executive Boulevard, Room 7187, MSC 9641