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News and Multimedia from 2006 Featuring DSIR

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Older Medication May Be More Cost-Effective for Some Patients with Schizophrenia

Press Release

National Institute of Mental Health

A new study analyzing the economic implications of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) concludes that the older (first generation) antipsychotic medication perphenazine was less expensive and no less effective than the newer (second generation) medications used in the trial during initial treatment, suggesting that older antipsychotics still have a role in treating schizophrenia.

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New NIMH Research Strives to Understand How Antidepressants May Be Associated with Suicidal Thoughts and Actions

Science Update

National Institute of Mental Health

The National Institute of Mental Health (NIMH), part of the National Institutes of Health, is funding five new research projects that will shed light on antidepressant medications, notably selective serotonin reuptake inhibitors (SSRIs), and their association with suicidal thoughts and actions.

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Odds of Beating Depression Diminish as Additional Treatment Strategies are Needed

Science Update

National Institute of Mental Health

An overall assessment of the nation’s largest real-world study of treatment-resistant depression suggests that a patient with persistent depression can get well after trying several treatment strategies, but his or her odds of beating the depression diminish as additional treatment strategies are needed.

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Antipsychotic Medications Used to Treat Alzheimer’s Patients Found Lacking

Press Release

National Institute of Mental Health

Commonly prescribed antipsychotic medications used to treat Alzheimer’s patients with delusions, aggression, hallucinations, and other similar symptoms can benefit some patients, but they appear to be no more effective than a placebo when adverse side effects are considered, according to the first phase of a large-scale clinical trial funded by NIMH.

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Subsequent Treatment Strategies for Persistent Depression Yield Modest Results

Science Update

National Institute of Mental Health

Patients with treatment-resistant depression had a modest chance of becoming symptom-free when they tried different treatment strategies after two or three failed treatments, according to results from the nation’s largest real-world study of depression.

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Switching to a Third Antidepressant Medication May Prove Helpful to Some with Treatment-Resistant Depression

Science Update

National Institute of Mental Health

The next wave of results from the nation’s largest real-world study of treatment-resistant depression shows that patients had a moderate chance of becoming symptom-free when they switchedto a third antidepressant medication, following two previously unsuccessful medication attempts.

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New Strategies Help Depressed Patients Become Symptom-Free

Press Release

National Institute of Mental Health

Results of the nation’s largest depression study show that one in three depressed patients who previously did not achieve remission using an antidepressant became symptom-free with the help of an additional medication and one in four achieved remission after switching to a different antidepressant.

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Early Findings from Largest NIMH-Funded Research Program on Bipolar Disorder Begin to Build Evidence-Base on Best Treatment Options

Science Update

National Institute of Mental Health

Findings from an NIMH research program on bipolar disorder provide much needed long-term data on the chronic, recurrent course of the disorder, and begin the work of building an evidence-base on the best treatments for those with the disorder.

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