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Psychosocial Intervention Efficacy Research Program


This program supports trials to evaluate the efficacy of psychosocial preventive and treatment interventions across all areas of adult mental disorders, including studies of established psychosocial interventions that are being applied to a different disorder for which efficacy has not yet been demonstrated. Studies which incorporate measures to study mechanisms of therapeutic change (psychosocial or biological), predictors of outcome, and multi-modal assessment of treatment outcome are particularly encouraged.

Areas of Emphasis

  • Identifying phenotypes and endophenotypes as new targets for assessment and therapeutics, that are emerging from integrative genetics, pathophysiology, and psychopathology research.
  • Conducting translational research on emotion and affect dysregulation to find new strategies for treating disorders of anxiety and mood.
  • Identifying ways in which genetic and environmental factors interact to raise or lower risk for mental disorders.
  • Developing new preventive and treatment interventions targeted to specific cognitive, emotional, or interpersonal components of the psychopathology of disorder.
  • Using modern psychometric and statistical theories to advance fundamental conceptualizations of nosology and consequent approaches toward more focused assessment and treatment of the many dimensions and subtypes that constitute complex psychiatric disorders.


Michael Kozak, Ph.D.
Program Chief
6001 Executive Boulevard, Room 7118, MSC 9625