NIMH designed the practical clinical trials to examine changes in both symptoms and functioning to determine whether a treatment improves quality of life, care-giving burden, or use of health services.
These "effectiveness studies" are part of a rigorous effort to discover what therapies work best. The practical clinical trials are:
Clinical Antipsychotic Trials of Intervention Effectiveness
Sequenced Treatment Alternatives to Relieve Depression Study
Systematic Treatment Enhancement Program for Bipolar Disorder
Treatment for Adolescents with Depression Study
Treatment of SSRI-resistant Depression in Adolescents study