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NIMH Administrative Supplement Program to Enable Continuity of Research Experiences of M.D./Ph.D.s during Clinical Training

Research Opportunity

The goal of this program is to help M.D./Ph.D.s move more efficiently and effectively from the period of clinical training to the next stage of their research careers by supporting focused, protected research time during residency or clinical fellowship. The proposed research experience must be an integral part of the approved, ongoing research of the parent grant and must have the potential to contribute significantly to the candidate’s research career. Applications are expected to summarize: a) the candidate’s supplemental research project, and b) a plan that is designed to enhance his/her research skills, scientific knowledge, and related professional skills including plans for subsequent funding applications that would help maintain the candidate’s research momentum. To ensure flexibility of research opportunities, the specific plan and scope of the research experience may vary depending on such factors as the year in residency, the nature of the parent grant, the candidate’s technical skill set and goals, and the candidate’s available effort. Applications are strongly encouraged to document the Principal Investigator’s commitment to provide appropriate guidance and supervision of the candidate.

Plans that primarily involve clinical interviewing and/or conducting laboratory sessions with research participants would be considered a low priority for this supplement program.

Candidates must meet the following eligibility criteria at the time of application: 1) must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence; 2) must have graduated from a combined M.D./Ph.D. program or must have graduated from independent M.D. and Ph.D. programs (in either order of completion) with time between the awarding of the two degrees not to exceed 10 years; 3) must currently be in good standing in an ACGME-accredited residency program or clinical fellowship program; 4) must be able to commit appropriate effort to the proposed research experience in any year; and 5) must not currently have support to obtain research experience from either federal or non-federal funds. Candidates during residency must commit no less than 1.8 person-months (15% of full-time effort) to the proposed research experience; at the time of award, candidates must be in PGY2 of residency or beyond. Candidates during fellowship must commit no less than 6 person-months (50% of full-time effort) to the proposed research experience.

The Department Chair and Residency Director must document that the research activities and associated time commitment proposed in the supplemental application will be supported by the institution and will not adversely affect the candidate’s board eligibility or prolong the period of residency or clinical fellowship, as appropriate.

The following submission instructions are intended to be used in conjunction with the Notice  for this administrative supplement program.

Submission Instructions

An application to the NIMH Administrative Supplement Program to Enable Continuity of Research Experiences of M.D./Ph.D.s during Clinical Training  is intended to document: 1) the quality of the proposed research plan and its appropriateness for the candidate’s current career stage; 2) the candidate’s qualifications and potential as a physician-scientist conducting independent, mental health-related research; 3) the alignment of the proposed research plan with the mission and strategic research priorities of the NIMH or, for AIDS-related applications, as exemplified in the research priorities of the most recent, annual Trans-NIH Plan for HIV-Related Research  and the priorities of the NIMH Division of AIDS Research; and 4) the commitment of the Program Director/Principal Investigator (PD/PI) and other faculty (if applicable) to provide appropriate guidance and supervision of the candidate’s research experience and facilitate his/her successful transition to the next career stage. Therefore, it is expected that the application will reflect the individual needs of the candidate who is being nominated for support.

Submit applications to NIMH electronically as a single document. The PD/PI is responsible for submitting the administrative supplement application. He/She should log into the NIMH Administrative Supplement website  using his/her eRA Commons ID and password. Applications should be submitted as “NOT-MH-11-014” when prompted for the Supplement Type.

  1. PHS 398 Form Page 1 (Face page) MS Word  PDF 
    • The title of the project (Box 1) should be the title of the parent award.
    • The number and title of this Notice should be cited in Box 2, and the “yes” box should be checked.
    • The Principal Investigator (PI) must be the same as the PI on the parent award. For Multiple PI parent awards, the Contact PI must be the PI listed on the supplement request, and the supplement cannot change the Multiple PI team.
    • The remaining items on the face page should be completed in accordance with the current PHS 398 application instructions.
  2. PHS 398 Form Page 2 MS Word  PDF 

    Note: The project “summary” is that of the administrative supplement, not the parent grant.

  3. A brief description of the project (not to exceed 5 pages), including:
    1. Research and Career Development Plan. An appropriate research plan for the candidate is a key component of the application and should be developed jointly by the PI and the candidate. In addition to summarizing the candidate’s proposed research, this plan must describe how the research experience will expand and foster the candidate’s research capabilities and how the candidate’s research relates to the research goals and objectives of the parent grant. The plan should present evidence that the proposed experience is appropriate for the stage of the candidate’s research development, and that it will significantly enhance the individual’s research potential, while furthering the candidate’s ability to pursue a mental health research career. Required components of the plan include:
      • Details regarding interactions of the PI and the candidate. The plan should go well beyond stating that the candidate will attend seminars and lab meetings. The plan should be detailed and include the frequency of meetings, topics to be discussed, and how progress will be monitored. Appropriate milestones for progress might include submission of abstracts for scientific meetings or preparation and submission of manuscripts for publication, depending on the career stage of the candidate. Plans for successful transition to the next stage in the candidate’s career path should be described. Regardless of the candidate’s career stage, guidance in the preparation of grant applications for submission to NIMH is an expected component of the plan.
      • The PI must describe how she/he will assist the candidate in achieving the objectives and goals described in the candidate’s statement (see below).
      • A description of the candidate’s research plan and the relationship of the proposed research to the parent grant and the mission and research priorities of the NIMH as exemplified in the NIMH Strategic Plan or, for AIDS-related applications, as exemplified in the research priorities of the most recent, annual Trans-NIH Plan for HIV-Related Research  and the priorities of the NIMH Division of AIDS Research.
      • A timeline for the proposed activities including milestones for progress.
    2. Experience of the PI. The PI must document his/her experience and track record as a supervisor highlighting experience guiding M.D./Ph.D.-educated individuals and including a list of past proteges and their current positions. If the PI is a junior faculty member, it may be appropriate to include an experienced investigator. The role(s) of any other contributing investigators should be described, and their BioSketches must be included with the application.
  4. Candidate’s Statement (not to exceed 3 pages). The candidate must provide a signed statement outlining career stage-appropriate, short- and long-term research objectives and career goals. The candidate’s statement is expected to summarize prior research experience, how the planned activities are related to and will facilitate achievement of his/her short- and long-term career goals, and how his/her research goals intersect with the mission and strategic priorities of the NIMH.
  5. Statement of Eligibility (not to exceed 2 pages). The application should include a signed statement from the PI, the director of the residency or clinical fellowship program, the department chair, and an Authorized Signing Official for the institution certifying eligibility of the candidate for support under this program. The statement must include 1) certification that the candidate is a citizen or non-citizen national of the U.S. or has been lawfully admitted for permanent residence; 2) certification that the candidate is in good standing in a full-time, clinical fellowship program or an ACGME-accredited U.S. residency program; 3) a description of the candidate’s current support and plans for his/her future support during residency or clinical fellowship, as appropriate; and 4) if applicable, a statement that the candidate has not received any current or previous PHS support. In addition, the department chair and director of the residency or clinical fellowship program must document the institution’s commitment to the research activities and associated time commitment proposed in the supplemental application and that this commitment will not affect the candidate’s board eligibility or prolong the period of residency or clinical fellowship, as appropriate.

    If support is requested for a candidate during residency and the candidate is at an institution with an NIMH-supported research residency program (R25), then a letter should also be included from the R25 PD/PI detailing why the current candidate cannot be supported on the research residency program.

  6. A proposed budget with justification that details the items requested, including Facilities and Administrative costs, entered on PHS 398 Form Page 4 (MS Word  PDF ) and PHS 398 Form Page 5 (MS Word  PDF ). The NIMH will provide salary support for the candidate in addition to other justified expenses, such as travel and supplies, to enable the candidate to participate fully in the proposed research experience. The requested salary and fringe benefits must be in accordance with the salary structure of the grantee institution for individuals in comparable positions, consistent with the level of effort, and may generally not exceed $75,000 per year. Funds up to $10,000 may be requested for supplies and travel for the candidate. No supplement funds may be used to purchase equipment. Total direct costs may not exceed $85,000 annually.
  7. Biographical Sketches for the candidate and any Investigators who will contribute to the candidate’s supervision MS Word  PDF . Each Investigator’s Biographical Sketch should document that individual’s qualifications and experience to guide the candidate and specifically describe his/her role in the candidate’s research experience.
  8. Human Subjects/Vertebrate Animal documentation (if applicable). Include a current Human Subjects/IRB or Vertebrate Animals/IACUC approval letter, if available. Otherwise, this information will be required at the time of funding. All appropriate IRB and IACUC approvals must be in place prior to a supplement award being made.

    Any differences in the involvement or use of human subjects or specimens, or use of vertebrate animals, between the administrative supplement activity and the parent grant should be noted. When appropriate, details should be provided on the protection of human subjects and inclusion of women, children, and minorities. Additional guidance on Human Subjects Research and Vertebrate Animals is found under Part II of the PHS 398 instructions .

  9. PHS 398 Checklist Form MS Word  PDF . If any of the research is to be conducted at a site other than the grantee institution, submit an appropriately signed letter from the institution where the research is to be conducted. This request must be signed by the candidate, Principal Investigator, and the appropriate Authorized Signing Official.

Selection Factors

Administrative supplement requests will be reviewed administratively by NIMH Program and Grants Management Staff. Selection factors will include the following:

  • Scientific merit of the proposed research plan;
  • Candidate’s potential for an independent research career conducting NIMH-relevant research;
  • Relevance of the proposed activities to the funded (parent) grant and the mission and research priorities of the NIMH as exemplified in the NIMH Strategic Plan or, for AIDS-related applications, as exemplified in the research priorities of the most recent, annual Trans-NIH Plan for HIV-Related Research  and the priorities of the NIMH Division of AIDS Research; and
  • Merit and appropriateness of the proposed research experience plan including evidence that the proposed activities are feasible within the context of residency and/or clinical fellowship and that sufficient institutional commitment exists for the proposed research experience.

An award issued under this Notice is contingent upon adequate progress on the parent grant during the current project period, the availability of funds, and the receipt of a sufficient number of meritorious applications.

Inquiries

Before submitting an application for this program, applicants are strongly encouraged to contact the appropriate individual listed under Inquiries in NOT-MH-11-014  to discuss their plans and to address any questions.