Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
- Anxiety and Recurrent Abdominal Pain in Children.
Interventional study. This study aims to determine whether citalopram is a useful, well-tolerated, and safe treatment for children and adolescents ages 7 to 18 years with functional abdominal pain. Ages 7-18. Location in Columbus, OH.
- Child and Adolescent Anxiety Disorders (CAMS).
Interventional study. This 9-month study will compare the effectiveness of the medication sertraline (Zoloft®), cognitive-behavioral therapy, the combination of these treatments, and placebo for youth with anxiety disorders. Ages 7-17.
- Spatial Context and Fear Learning.
Evaluation study. Background: - Fear is a normal response to a threat. Ages 18-50. Location in Bethesda, MD.
- PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX.
Evaluation study. Objective: Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that respond to glutamate by activating proteins inside nerve cells that affect cell metabolism, thereby fine-tuning the signals sent between cells to maintain balance in neuronal activity. Ages 18-55. Location in Bethesda, MD.
- Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety.
Interventional study. Background: Stress and anxiety can interfere with how well people perform tasks. Ages 18-50. Location in Bethesda, MD.
- A Pilot Study to Extend the K-SADS-PL to Adolescents and Young Adults.
Evaluation study. Background: - An interview called the Schedule for Affective Disorders and Schizophrenia for School Age Children Present and Lifetime version (K-SADS-PL) is used to identify mental health problems among children and younger teens. Ages 18-80. Location in Bethesda, MD.
- Family Study of Affective and Anxiety Spectrum Disorders.
Evaluation study. This study will examine how depression, anxiety, and migraine run in families. Ages up to 60. Location in Bethesda, MD.
- Generalized Anxiety Disorder and Social Anxiety Disorder: Their Impact on the Processing of Information and Learning.
Evaluation study. The purpose of this study is to increase researchers understanding of the biological basis of generalized anxiety disorder and social anxiety disorder. Ages 18-50. Location in Bethesda, MD.
- The Psychobiology of Childhood Temperament.
Evaluation study. The purpose of this study is to use brain imaging technology to examine brain changes that occur in children when they are exposed to various kinds of emotional tasks and to determine if these changes are related to the child's temperament. Ages 7-25. Locations in Bethesda, MD; College Park, MD.
- Expectation of Unpleasant Events in Anxiety Disorders.
Evaluation study. Fear and anxiety are normal responses to a threat. Ages 18-60. Location in Bethesda, MD.
- Brain Changes in Fear.
Evaluation study. The purpose of this study is to use brain imaging technology to investigate brain changes in people exposed to predictable versus unpredictable unpleasant stimuli. Ages 18-50. Location in Bethesda, MD.
- Effects of Arousal and Stress in Anxiety.
Evaluation study. This study has several parts. Ages 18-50. Location in Bethesda, MD.
- Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers.
Evaluation study. The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Mood and Anxiety Disorders Program (MAP) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. Ages 3 and over. Location in Bethesda, MD.