Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
- Neurobiology of Suicide.
Interventional study. Background: There are no good treatments for people considering suicide. Ages 18-70. Location in Bethesda, MD.
- Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Disorder.
Interventional study. Background: - Drugs and talk therapy help treat depression, but these treatments usually take quite a bit of time to work. Ages 18-65. Location in Bethesda, MD.
- PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX.
Evaluation study. Objective: Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that respond to glutamate by activating proteins inside nerve cells that affect cell metabolism, thereby fine-tuning the signals sent between cells to maintain balance in neuronal activity. Ages 18-55. Location in Bethesda, MD.
- Ask Suicide-Screening Questions to Everyone in Medical Settings (asQ em): Development of a Suicide Risk Screening Instrument for Adult Medical Inpatients.
Evaluation study. Background: - Suicide is the 10th leading cause of death for U.S. Ages 18 and over. Location in Bethesda, MD.
- The Neurophysiological Effects of Intravenous Alcohol as Potential Biomarkers of Ketamine's Rapid Antidepressant Effects in Major Depressive Disorder.
Interventional study. Objective: Glutamate-based medications including the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine result in rapid, robust and sustained (up to one week) antidepressant effects in randomized controlled trials in treatment-refractory unipolar and bipolar depression. Ages 21-65. Location in Bethesda, MD.
- Study to Determine if Enhancing Glutamate Transporter Function Produces Antidepressant Effects in People With Major Depressive Disorder.
Interventional study. Background: - Depressed people appear to have problems regulating levels of a brain chemical called glutamate than people who are not depressed. Ages 18-65. Location in Bethesda, MD.
- Brain Inflammation in Major Depressive Disorder Background.
Evaluation study. Background: - Studies have shown that inflammation plays an important role in depression. Ages 18 and over. Location in Bethesda, MD.
- A Pilot Study to Extend the K-SADS-PL to Adolescents and Young Adults.
Evaluation study. Background: - An interview called the Schedule for Affective Disorders and Schizophrenia for School Age Children Present and Lifetime version (K-SADS-PL) is used to identify mental health problems among children and younger teens. Ages 18-80. Location in Bethesda, MD.
- Preventing Depression in People Receiving Mechanical Ventilation in an Intensive Care Unit.
Interventional study. This study will determine the effectiveness of antidepressant medication in preventing depression and improving recovery in people who have been supported by mechanical ventilators in an intensive care unit (ICU). Ages 25 and over.
- Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder.
Interventional study. This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder. Ages 12-17. Location in New York, NY.
- Prevention of Depression in Spouses of People With Cognitive Impairment.
Interventional study. This study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or family caregivers of persons with mild cognitive impairment or early dementia. Ages 18 and over. Location in Pittsburgh, PA.
- Genetics of Recurrent Early Onset Major Depression.
Evaluation study. This study will identify specific genes that may cause a predisposition to depression in some families. Ages 21-70.
- Cognitive Therapy Versus Medication Treatment for Preventing Depression Relapse.
Interventional study. This study will evaluate the longer term effectiveness of cognitive therapy (CT) versus medication treatment or placebo for prevention of recurrence of depression for 24 months after termination of continuation phase therapy. Ages 18-70.
- Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram.
Interventional study. This study will evaluate changes in brain energy metabolism due to treatment with escitalopram in people with major depressive disorder. Ages 18-65.
- A Clinic-Based Prevention Program for Families of Depressed Mothers.
Interventional study. This study will assess the effectiveness of the "Keeping Families Strong" program (KFS) in avoiding or delaying the onset of psychiatric disorders among children with depressed mothers. Ages 8 and over. Location in Baltimore, MD.
- Parent Psychoeducation and Cognitive Behavior Therapy for Latino Adolescents With Depression.
Interventional study. This study will determine the effectiveness of adding a parent-involved intervention to cognitive behavior therapy in reducing depressive symptoms among Latino adolescents with depression. Ages 13-17. Location in San Juan, Puerto Rico.
- Adding Exercise to Antidepressant Medication Treatment for Depression.
Interventional study. This study will assess the effectiveness of an exercise program in improving antidepressant medication treatment for individuals with major depressive disorder (MDD). Ages 18-70.
- Clinical Trial of Estrogen for Postpartum Depression.
Interventional study. This study evaluates the efficacy of estrogen treatment in women with postpartum depression (PPD). Ages 20-45. Location in Bethesda, MD.