Clinical Trials
Depression
Featured Studies
Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
- Effects of Antidepressant Therapy on Brain Dopamine Transporter Activity in People With Major Depression.
Interventional study. This study will examine changes in brain dopamine transporter activity before and after antidepressant therapy. Ages 18-65. Location in Philadelphia, PA.
- Effects of Cognitive Behavioral Therapy on Brain Serotonin Activity in People With Depression.
Interventional study. This study will examine changes in brain serotonin activity in people with depression before and after they receive cognitive behavioral therapy. Ages 18-65. Location in Philadelphia, PA.
- Effectiveness of Group Interpersonal Psychotherapy in Treating Women With Prenatal Depression.
Interventional study. This study will evaluate the effectiveness of group interpersonal psychotherapy for preventing postpartum depression in pregnant women with depression and for improving healthy outcomes in their babies. Ages 18-40. Location in New York, NY.
- Effectiveness of Adding Relapse Prevention Cognitive Behavioral Therapy to Fluoxetine Treatment for Pediatric Major Depressive Disorder.
Interventional study. This study will compare the effectiveness of fluoxetine alone with the effectiveness of fluoxetine with cognitive behavioral therapy in increasing recovery and preventing relapse in youth with major depressive disorder. Ages 8-17. Location in Dallas, TX.
- Effect of Antidepressants on Sex Hormone Levels and Sexual Functioning.
Interventional study. This study will evaluate the effect of antidepressants on sex hormone levels in women and if the potential changes in sex hormone levels are related to sexual side effects. Ages 18-45. Location in New York, NY.
- Effectiveness of Internet-Based Cognitive Behavioral Therapy for Treating Mothers With Depression.
Interventional study. This study will evaluate the effectiveness of an Internet-based cognitive behavioral therapy program in treating mothers with depression who have young children. Location in Eugene, OR.
- Interpersonal Therapy Program for Preventing Postpartum Depression.
Interventional study. This study will evaluate the effectiveness of an interpersonal therapy treatment called the Postpartum Prevention Program in preventing the development of postpartum depression in pregnant women who are financially disadvantaged. Ages 18-40. Locations in Pawtucket, RI; Providence, RI; Woonsocket, RI.
- Interpersonal Treatment Program to Prevent Depression and Post-Traumatic Stress Disorder in Low-Income Pregnant Women With Partner Abuse.
Interventional study. This study will evaluate the effectiveness of an interpersonally oriented treatment program called Reach Out for a Safe Environment in preventing depression and post-traumatic stress disorder in low-income pregnant women who have experienced recent partner abuse. Ages 18-40. Location in Providence, RI.
- Safety and Effectiveness of Antidepressant Therapy in Treating Bipolar Type II Major Depression.
Interventional study. This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression. Ages 18 and over. Location in Philadelphia, PA.
- Problem-Solving Therapy for People With Major Depression and Chronic Obstructive Pulmonary Disease.
Interventional study. This study will evaluate the effectiveness of problem-solving therapy combined with treatment adherence procedures in treating older people with major depression and chronic obstructive pulmonary disease. Ages 50-95. Location in White Plains, NY.
- Effectiveness of Cognitive Behavioral Therapy in Reducing Depressive Symptoms in Physically Ill Youth.
Interventional study. This study will compare the effectiveness of cognitive behavioral therapy with supportive nondirective therapy in reducing emotional distress and improving functioning in youth with inflammatory bowel disease and depression. Ages 9-17. Locations in Boston, MA; Pittsburgh, PA.
- Effectiveness of Parent-Child Interaction and Emotion Development Therapy in Treating Preschool Children With Depression.
Interventional study. This study will evaluate the effectiveness of parent-child interaction therapy that includes an emotion development component in treating depression in preschool children. Ages 3-6. Location in St. Louis, MO.
- Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder.
Interventional study. This study will compare the effectiveness of cognitive behavioral therapy versus supportive psychotherapy in decreasing depression in people with bipolar disorder. Ages 18-64. Location in Boston, MA.
- Combining Medications to Enhance Depression Outcomes.
Interventional study. This study will compare whether a combination of antidepressant medications is better than one antidepressant medication alone when given as initial treatment for people with chronic or recurrent major depressive disorder. Ages 18-75. Locations in Tuscaloosa, AL; Harbor City, CA; Los Angeles, CA; San Diego, CA; Chicago, IL; Wichita, KS; Salem, MA; Ann Arbor, MI; Chapel Hill, NC; New York, NY; Tulsa, OK; Pittsburgh, PA; Nashville, TN; Dallas, TX; Richmond, VA.
- Effectiveness of Behavioral Treatments for Obesity and Major Depression in Women.
Interventional study. This study will compare the effectiveness of two weight loss programs, one supplemented with health education and the other supplemented with behavioral counseling, in treating women who are depressed and overweight. Ages 21-65. Location in Worcester, MA.
- Effects of Adding Motivational Interviewing to Antidepressant Treatment for Hispanic Adults With Depression.
Interventional study. This study will evaluate the effectiveness of adding motivational interviewing to antidepressant treatment for major depressive disorder in Hispanic adults. Ages 18-79. Location in New York, NY.
- Effectiveness of Cognitive Behavioral Therapy in Improving Adherence and Depressive Symptoms in People With Diabetes.
Interventional study. This study will evaluate the effectiveness of cognitive behavioral therapy (CBT) in treating people with depression and type 2 diabetes. Ages 18-70. Location in Boston, MA.
- Effectiveness of Case Management Versus Case Management Plus Problem-Solving Therapy to Treat Depression in Low-Income Elders.
Interventional study. This study will compare the effectiveness of case management combined with problem-solving therapy (CM-PST) versus case management (CM) alone for assisting elderly people with depression. Ages 65-95. Locations in San Francisco, CA; White Plains, NY.
- Evaluating the Effectiveness of Escitalopram to Prevent Depression in Head and Neck Cancer Patients Receiving Treatment.
Interventional study. This study will evaluate the effectiveness of escitalopram to prevent depression in head and neck cancer patients receiving treatment. Ages 19 and over. Location in Omaha, NE.
- Evaluating a Behavioral Activities Treatment Program for Depressed Nursing Home Residents.
Interventional study. This study will evaluate whether a behavioral activities treatment program improves symptoms of depression in nursing home residents. Location in Louisville, KY.
- Evaluating the Effects of Stress in Pregnancy.
Evaluation study. This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy. Ages 18-45. Location in Atlanta, GA.
- Developing a Self-Management Program for People With Depression and Chronic Medical Illness.
Interventional study. This study seeks to adapt an existing chronic disease self-management program for people with both chronic medical illness and depression. Ages 18-70. Location in Los Angeles, CA.
- Pharmacogenomics of Antidepressant Response in Children and Adolescents.
Evaluation study. This study will identify variations in genes that may be involved in the development of suicidal events or certain behaviors in youth who are exposed to antidepressant medications. Ages 7-17. Location in Durham, NC.
- Omega-3 Fatty Acids for Treating Adults With Major Depression.
Interventional study. This study will test the effectiveness of two different kinds of omega-3 fatty acid dietary supplements in treating the symptoms of major depression. Ages 18-80. Location in Los Angeles, CA.
- Antidepressant Medication and Cognitive Behavioral Therapy to Help HIV Infected Adults With Depression to Adhere to Antiretroviral Therapy.
Interventional study. This study will compare the effectiveness of antidepressant therapy alone versus antidepressant therapy combined with cognitive behavioral therapy in helping HIV infected adults with depression to take their medications on schedule. Ages 18-60. Location in Torrance, CA.
- Nurse-Led Case Management for Diabetes and Cardiovascular Disease Patients With Depression.
Interventional study. This study will evaluate the effectiveness of a nurse-led case management intervention in improving disease control and depression symptoms in adults with diabetes and/or heart disease who are also depressed. Ages 18-80. Location in Seattle, WA.
- Reducing Health Risk Behavior and Improving Health in Adolescents With Depression.
Interventional study. This study will determine the effectiveness of a health education intervention in reducing health risk behavior and improving health in adolescents with depression. Ages 13-18. Location in Los Angeles, CA.
- Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment.
Interventional study. This study will use pre-treatment positron emission topography and functional magnetic resonance imaging scans of the brain to predict the most effective antidepressant treatment for people with major depressive disorder. Ages 18-65. Location in New York, NY.
- Interpersonal Therapy-Based Treatment to Prevent Postpartum Depression in Adolescent Mothers.
Interventional study. This study will aim to prevent postpartum depression in pregnant teenagers through an interpersonal therapy-based program. Ages 12-18. Location in Providence, RI.
- Paroxetine/Bupropion in Suicide Attempters/Ideators With Major Depression.
Interventional study. This study will compare the effectiveness of two antidepressant medications in treating depression in people who have attempted suicide or are currently experiencing suicidal ideation. Ages 18-75. Location in New York City, NY.
- Antidepressant Safety in Kids (ASK) Study.
Evaluation study. This study will evaluate the risks and benefits of treatment with a selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor in children and adolescents with a pre-specified anxiety disorder, depressive disorder, eating disorder, or obsessive-compulsive disorder. Ages 7-17. Location in Durham, NC.
- Effects of Interpersonal Psychotherapy on Depression During and After Pregnancy.
Interventional study. This study will evaluate the impact of interpersonal psychotherapy on the course of depression during and after pregnancy, as well as its effect on infant birth outcomes. Ages 21-45. Location in Ann Arbor, MI.
- Effectiveness of Problem Solving Therapy in Treating Depressed, Cognitively Impaired Older Adults.
Interventional study. This study will evaluate the effectiveness of problem solving therapy in treating depressed, cognitively impaired older adults. Ages 65 and over. Location in White Plains, NY.
- Effectiveness of a Telephone-Delivered Behavioral Treatment to Improve the Quality of Life of Older Adults With HIV.
Interventional study. This study will evaluate the effectiveness of a telephone-delivered coping improvement group intervention in improving quality of life in older adults with HIV. Ages 50 and over. Location in Athens, OH.
- Identifying Factors That Predict Antidepressant Treatment Response.
Interventional study. This study will identify factors that may predict treatment response by comparing the effectiveness of three antidepressant treatments (two antidepressant medications and cognitive behavior therapy) in people with major depressive disorder. Ages 18-65. Location in Atlanta, GA.
- Motivational Interviewing to Improve Medication Adherence Among Hispanic Adults With Depression.
Interventional study. This study will determine the effectiveness of motivational interviewing in improving antidepressant medication adherence among Hispanics. Ages 18-65. Location in New Brunswick, NJ.
- Interpersonal Psychotherapy for Depression in People With Heart Failure.
Interventional study. This study will evaluate the effectiveness of interpersonal psychotherapy and behavioral activation techniques in treating depression in people with congestive heart failure. Ages 55 and over. Location in Iowa City, IA.
- Evaluating the Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment.
Interventional study. This study will determine the effectiveness of an antidepressant in preventing or reducing depressive symptoms in people with melanoma who are receiving Interleukin-2 (IL-2) treatment. Ages 18-75. Location in Atlanta, GA.
- Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy.
Interventional study. This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally housed people with depression. Ages 18 and over. Location in San Francisco, CA.
- Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder.
Interventional study. This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder. Ages 12-17. Location in New York, NY.
- Prevention of Depression in Spouses of People With Cognitive Impairment.
Interventional study. This study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or significant others of people with mild cognitive impairment. Ages 18 and over. Location in Pittsburgh, PA.
- Integrated Parent Training for Treating Depression in Mothers of Children With Attention Deficit Hyperactivity Disorder (ADHD).
Interventional study. This study will determine the effectiveness of integrated parent training versus standard behavioral parent training in treating depression and stress in mothers of children with attention deficit hyperactivity disorder (ADHD). Ages 6 and over. Location in College Park, MD.
- Effectiveness of Antidepressant Treatment for Depression in People With Parkinson's Disease.
Interventional study. This study will evaluate the effectiveness of atomoxetine in reducing symptoms of depression in people with Parkinson's disease. Ages 30-79. Location in Philadelphia, PA.
- Identification and Therapy of Postpartum Depression.
Interventional study. This study will evaluate the effectiveness of a telephone-based depression screening and care management program in treating depression in postpartum women. Ages 18 and over. Location in Pittsburgh, PA.
- Bipolar II Depression: Lithium, SSRI, or the Combination.
Interventional study. This study will compare the safety and effectiveness of a mood stabilizing medication, an antidepressant medication, and a combination of both medications to treat symptoms of bipolar type II depression. Ages 18-65. Locations in Los Angeles, CA; Cincinnati, OH; Dallas, TX.
- Genetics of Recurrent Early Onset Major Depression.
Evaluation study. This study will identify specific genes that may cause a predisposition to depression in some families. Ages 21-70. Locations in Palo Alto, CA; Washington, DC; Iowa City, IA; Chicago, IL; Baltimore, MD; New York, NY.
- Effectiveness of Interpersonal Psychotherapy in Treating Pregnant Women With Depression.
Interventional study. This study will evaluate the effectiveness of interpersonal psychotherapy in treating pregnant women with depression. Ages 18-47. Location in New York, NY.
- Improving Sleep and Psychological Functioning in People With Depression and Insomnia.
Interventional study. This study will evaluate the safety and effectiveness of treatment with both a sleeping pill and antidepressant medication in improving sleep and psychological functioning in people with depression and insomnia. Ages 18-70. Location in Winston-Salem, NC.
- Effectiveness of Culturally Based Congruent Care in Treating Hispanics With Major Depressive Disorder.
Interventional study. This study will develop and evaluate the effectiveness of a culturally based program that aims to facilitate entry, retention, and successful treatment in specialized mental health services for Hispanics with major depressive disorder. Ages 18-80. Location in New York, NY.
- Cognitive Therapy Versus Medication Treatment for Preventing Depression Relapse.
Interventional study. This study will evaluate the longer term effectiveness of cognitive therapy (CT) versus medication treatment or placebo for prevention of recurrence of depression for 24 months after termination of continuation phase therapy. Ages 18-70. Locations in Philadelphia, PA; Dallas, TX.
- Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults.
Interventional study. This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or cardiopulmonary condition. Ages 60 and over. Location in Pittsburgh, PA.
- Understanding Brain Reward Responses in Individuals With Major Depressive Disorder.
Evaluation study. This study will examine brain responses associated with reinforcement and reward tasks in individuals with major depressive disorder (MDD). Ages 18-64. Locations in Boston, MA; Cambridge, MA; Charlestown, MA.
- Determining Changes in Brain Structure Associated With Symptoms of Late-Life Depression.
Evaluation study. This study will determine the changes in brain structure and function that are responsible for mood and cognition changes that are sometimes associated with late-life depression. Ages 55 and over. Location in Pittsburgh, PA.
- Characterizing Psychological Consequences of Childhood Trauma.
Evaluation study. This study will characterize the mental health consequences of early-life trauma. Ages 18-45. Location in Atlanta, GA.
- Depression Prevention Program for Adolescents.
Interventional study. This study will compare the effectiveness of two programs designed to prevent depression in adolescents. Ages 14-18. Location in Austin, TX.
- Maintenance Treatment of Bipolar Depression.
Interventional study. This study will compare two different antidepressant treatment regimens to determine which is more effective in reducing symptoms of bipolar depression. Ages 18 and over. Location in San Antonio, TX.
- Family Cognitive Behavioral Therapy for Preventing Depression in Children.
Interventional study. This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus educational treatment in preventing depression in the children of parents with a history of depression. Ages 10 and over. Location in Nashville, TN.
- Cognitive Therapy for Treating Depression and Preventing Relapse.
Interventional study. This study will compare the effectiveness of cognitive therapy versus antidepressant medication in treating depression and preventing relapse in individuals with recurrent depression. Ages 18-70. Location in Pittsburgh, PA.
- Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram.
Interventional study. This study will evaluate changes in brain energy metabolism due to treatment with escitalopram in people with major depressive disorder. Ages 18-65. Location in Boston, MA.
- Sertraline for Preventing Post-Stroke Depression and Improving Rehabilitation Outcomes.
Interventional study. This study will determine the effectiveness of sertraline administration after a stroke in preventing the onset of post-stroke depression. Ages 40 and over. Location in Pittsburgh, PA.
- Treating Post Traumatic Stress Disorder in Children Exposed to Domestic Violence.
Interventional study. This study will determine whether trauma-focused cognitive behavioral therapy (TF-CBT) is more effective than child-centered therapy (CCT) in reducing post traumatic stress disorder (PTSD) in children exposed to domestic violence (DV). Ages 7-14. Location in Pittsburgh, PA.
- Effect of Family-Based Prevention on Children of Depressed Parents.
Interventional study. This study will test the Protecting Families Program, a 10-week prevention program for depressed parents and their pre-teenage children, by comparing the effectiveness of the program versus parent training alone. Ages 9 and over. Location in Philadelphia, PA.
- Hypothalamus-Pituitary-Adrenal Axis and Use of Mifepristone for Psychotic Depression.
Interventional study. This study will evaluate the effectiveness of mifepristone to treat adults with psychotic major depression. Ages 18-85. Location in Palo Alto, CA.
- A Clinic-Based Prevention Program for Families of Depressed Mothers.
Interventional study. This study will assess the effectiveness of the "Keeping Families Strong" program (KFS) in avoiding or delaying the onset of psychiatric disorders among children with depressed mothers. Ages 8 and over. Location in Baltimore, MD.
- Magnetic Brain Stimulation for the Treatment of Adult Depression.
Interventional study. This study will evaluate the safety and effectiveness of magnetic brain stimulation for the treatment of major depression in depressed adults with moderate treatment resistance. Ages 21-70. Locations in Atlanta, GA; New York, NY; Charleston, SC; Seattle, WA.
- Cognitive Therapy for Recurrent Depression.
Interventional study. This study will determine the effectiveness of continuation phase cognitive therapy versus antidepressant medication in preventing relapse of depression in people with recurrent depression. Ages 18-70. Locations in Pittsburgh, PA; Dallas, TX.
- Parent Psychoeducation and Cognitive Behavior Therapy for Latino Adolescents With Depression.
Interventional study. This study will determine the effectiveness of adding a parent-involved intervention to cognitive behavior therapy in reducing depressive symptoms among Latino adolescents with depression. Ages 13-17. Location in San Juan, Puerto Rico.
- Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression.
Interventional study. This study will determine whether there are age-related differences in the body systems controlling sleep and stress hormone patterns. This study will also determine whether the differences in sleep and hormone patterns between depressed adolescents and adults are associated with differences in their response to antidepressant treatment. Ages 12-50. Location in Dallas, TX.
- Interventions for Depressed Low Income Mothers and Their Infants.
Interventional study. This study will compare three interventions for depressed, low income mothers and determine which is most effective in treating maternal depression and in fostering development in infants. Ages 18-44. Location in Rochester, NY.
- Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant Depression.
Interventional study. This study will determine the effectiveness of adding S-adenosyl methionine to antidepressant drug treatment in reducing depressive symptoms in depressed people who have not responded to antidepressants alone. Ages 18-80. Location in Boston, MA.
- Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure.
Interventional study. This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure. Ages 45 and over. Location in Durham, NC.
- Medication Treatment for Depression in Nursing Home Residents.
Interventional study. This study will examine therapeutic and adverse effects of continuing versus discontinuing antidepressant medication in nursing home residents who have had no more than a single episode of depression and who no longer have depressive symptoms. Ages 65 and over. Location in Philadelphia, PA.
- Reducing Symptoms of Depression in Low-Income Mothers.
Interventional study. This study will test the effectiveness of a short-term intervention in treating depressed young mothers with young children enrolled in Early Head Start Programs. Ages 15 and over. Locations in Asheville, NC; Chapel Hill, NC; Goldsboro, NC; Greensboro, NC; Syracuse, NY.
- Preventing Post-Stroke Depression.
Interventional study. This study will evaluate the effectiveness of both drug and non-drug treatments in preventing depression after a stroke. Ages 31-89. Locations in Iowa City, IA; Chicago, IL; White Plains, NY.
Search ClinicalTrials.gov for other NIH studies on Depression.
