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Depression

Featured Studies

Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.

  • PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX.
    Evaluation study. Objective: Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that respond to glutamate by activating proteins inside nerve cells that affect cell metabolism, thereby fine-tuning the signals sent between cells to maintain balance in neuronal activity. Ages 18-55. Location in Bethesda, MD.
  • A Pilot Study to Extend the K-SADS-PL to Adolescents and Young Adults.
    Evaluation study. Background: - An interview called the Schedule for Affective Disorders and Schizophrenia for School Age Children Present and Lifetime version (K-SADS-PL) is used to identify mental health problems among children and younger teens. Ages 18-80. Location in Bethesda, MD.
  • Hormonal Causes of Menstrual-Related Mood Disorders.
    Evaluation study. This study will explore possible hormonal causes of menstrual-related mood disorders (MRMD) by stopping the menstrual cycle with a drug called Lupron and then giving in sequence two menstrual cycle hormones, progesterone and estrogen. Ages 18-45.
  • Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers.
    Evaluation study. The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Mood and Anxiety Disorders Program (MAP) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. Ages 3 and over. Location in Bethesda, MD.
  • Brain Tissue Collection for Neuropathological Studies.
    Evaluation study. The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Locations in Bethesda, MD; Washington, DC; Fairfax, VA.
  • A Treatment Study for Premenstrual Syndrome (PMS).
    Evaluation study. This study examines the effects of estrogen and progesterone on mood, the stress response, and brain function and behavior in women with premenstrual syndrome. Ages 18-50. Location in Bethesda, MD.
  • Evaluation of the Genetics of Bipolar Disorder.
    Evaluation study. This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions. Ages 18 and over. Location in Bethesda, MD.

Search ClinicalTrials.gov for other NIH studies on Depression.