Clinical Trials
Miscellaneous Conditions
Featured Studies
Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
- Mentor Mothers: A Sustainable Family Intervention in South African Townships.
Interventional study. The purpose of this study is to test a mother-to-mother intervention during pregnancy and after delivery with Mothers Living with HIV (MLH)in South Africa. Ages 18 and over. Location in Pietermaritzburg, South Africa.
- Characterizing Lone Parenting: A Multi-institutional Pilot Study of the Perceptions of Support and Perceived Stress of Lone Parents of Children With Cancer.
Evaluation study. This study will describe the perceptions of support and distress outcomes of single/lone parents of a child with cancer. Ages 18-65. Locations in Birmingham, AL; Los Angeles, CA; Long Beach, CA; Bethesda, MD; Boston, MA; Jackson, MS; Rochester, NY; Akron, OH; Stillwater, OK; Pittsburgh, PA; Memphis, TN; Milwaukee, WI.
- Examining Behavior Therapy for Trichotillomania in Children and Adolescents.
Interventional study. This study will evaluate a treatment for trichotillomania, or compulsive hair pulling, in children and adolescents. Ages 10-17. Location in Philadelphia, PA.
- Examining an Exercise and Nutrition Program for Reducing Weight in People With Severe Mental Illnesses (The ACHIEVE Study).
Interventional study. This study will determine whether a nutrition and exercise program is effective in helping people with severe mental illnesses lose weight. Ages 18 and over. Location in Baltimore, MD.
- Examining the Effects of Antipsychotic Medications on Insulin Sensitivity.
Interventional study. This study will examine the effects of two different antipsychotic medications on control of blood sugar in people who are at risk of diabetes but mentally healthy. Ages 40-65. Location in San Diego, CA.
- Examining Physiology and Brain Function in People With the Fragile X Premutation.
Evaluation study. This study will examine whether individuals with the fragile X genetic premutation are likely to have emotional, social, and memory deficits and how the brain may be involved in these deficits. Ages 18-45. Location in Sacramento, CA.
- Testing a New Therapy for Trichotillomania.
Interventional study. This study will test the effectiveness of a new behavioral therapy for adults with trichotillomania (compulsive hair pulling). Ages 18-65. Location in Milwaukee, WI.
- Imaging Cannabinoid CB1 Receptors in Alcohol Dependence.
Evaluation study. The cannabinoid type 1 (CB1) receptor is a protein found in the brain that is involved with the effects of marijuana; it may also play a role in the effects of alcohol dependence and withdrawal. Ages 18-65. Location in Bethesda, MD.
- Reducing Weight Gain and Improving Metabolic Function in Children Being Treated With Antipsychotics.
Interventional study. This study will test the effectiveness of two different treatments for children and adolescents who have gained weight on their antipsychotic medications. Ages 8-17. Locations in Baltimore, MD; Glen Oaks, NY; Chapel Hill, NC.
- Effectiveness of Anger Management Treatment in Reducing Anger-Related Behaviors in Female Juvenile Offenders.
Interventional study. This study will evaluate the effectiveness of an anger management treatment program, Juvenile Justice Anger Management for Girls, in reducing anger-related behaviors displayed by girls in the juvenile justice system. Ages 12-19. Location in Philadelphia, PA.
- PET Imaging of Peripheral Benzodiazepine Receptors.
Evaluation study. This study will use positron emission tomography (PET) to measure a receptor in the brain that is involved in inflammation. Ages 18 and over. Location in Bethesda, MD.
- Mirror Therapy for Phantom Limb Pain.
Evaluation study. This study, conducted at the National Institutes of Health (NIH) and at Walter Reed Army Medical Center (WRAMC), will explore the phenomenon of phantom limb pain (a continued feeling of pain in an amputated limb) and will use functional magnetic resonance imaging (fMRI) to investigate the effect of mirror therapy on phantom limb pain. Ages 18-75. Locations in Washington, DC; Bethesda, MD.
- PET Imaging of P-glycoprotein Function Using [11C]dLop.
Evaluation study. This study will test the use of a radioactive substance called [11C]dLop for measuring P-glycoprotein (P-gp) using positron emission tomography (PET) imaging. Ages 18-50. Location in Bethesda, MD.
- PET Imaging of Cannabinoid CB1 Receptors Using [18F]FMPEP-d2.
Interventional study. The purpose of this protocol is to measure brain CB1 receptors in the hope to better understand how they work, so that one day we can understand how the CB1 receptors are involved in psychiatric, neurological, and behavioral disorders. Ages 18-65. Location in Bethesda, MD.
- PET Imaging of Cannabinoid CB1 Receptors Using [11C]MePPEP.
Interventional study. The purpose of this protocol is to measure brain CB1 receptors in the hope to better understand how they work, so that one day we can understand how the CB1 receptors are involved in psychiatric, neurological, and behavioral disorders. Ages 18-65. Location in Bethesda, MD.
- PET Imaging of Brain mGluR5 Receptors Using [18F]SP203.
Interventional study. The metabotropic glutamate subtype five (mGluR5) receptor is a protein found in the brain and is the target for the excitatory chemical messenger glutimate. Ages 18-65. Location in Bethesda, MD.
- PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [F-18]FB.
Interventional study. The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people. Ages 18-65. Location in Bethesda, MD.
- PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [C-11]PBR28.
Interventional study. The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people. Ages 18-65. Location in Bethesda, MD.
- Comparison of Two Psychosocial Therapies for Treating Children With Oppositional-Defiant Disorder.
Interventional study. This study will evaluate the effectiveness of two different psychosocial therapies, parent management training and collaborative problem solving, in treating children with oppositional-defiant disorder. Ages 8-12. Location in Blacksburg, VA.
- Effectiveness of Treatment for Relational Aggression in Urban African American Girls.
Interventional study. This study will evaluate the effectiveness of a school-based social cognitive group treatment in reducing aggression (bullying) among relationally aggressive urban African American girls. Location in Philadelphia, PA.
- Abuse-Focused Cognitive Behavioral Therapy for Children Who Have Been Physically Abused.
Interventional study. This study will determine the effectiveness of abuse-focused cognitive behavioral therapy that is provided by a community health clinic in addressing the behavioral and emotional health needs of children and adolescents whose parents have used physical disciplinary action. Ages 5-15. Location in Pittsburgh, PA.
- Internet-Based Treatment for Children With Traumatic Brain Injuries & Their Families: Counselor Assisted Problem Solving.
Interventional study. This study will evaluate the effectiveness of an Internet-based psychosocial treatment in improving problem-solving, communication skills, stress management strategies, and coping among children who have had a traumatic brain injury and their families. Ages 12-17. Locations in Denver, CO; Rochester, MN; Cleveland, OH; Cincinnati, OH.
- PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28.
Interventional study. In this study we will examine where the radioactive tracer [11C]PBR28 is distributed in the body of healthy volunteers to calculate the radiation exposure to organs of the body. Ages 18-65. Location in Bethesda, MD.
- Multi-Family Group Therapy for Reducing Behavioral Difficulties in Youth.
Interventional study. This study will examine the effectiveness of a multiple family group mental health service delivery strategy in improving mental health service use and outcome for urban, low income children of color, ages 7-11 years old with disruptive behaviors and their families. Ages 7 and over. Location in New York, NY.
- Protein Synthesis in the Brain of Patients With Fragile X Syndrome.
Evaluation study. Biosynthesis of proteins is essential for growth and continued maintenance of the entire neuron including axons, dendrites, and synaptic terminals, and it is clearly one of the important biochemical processes underlying adaptive changes in the nervous system. Ages 18-24. Location in Bethesda, MD.
- Comparing Cognitive Behavioral Therapy, Antidepressant Medication, and Combined Treatment in Individuals With Hypochondriasis.
Interventional study. This study will compare the effectiveness of cognitive behavioral therapy, antidepressant medication, and a combination of the two for treating hypochondriasis. Ages 21 and over. Locations in Boston, MA; New York City, NY.
- Safety and Effectiveness of Taking Choline Supplements During Pregnancy for Improving Infant Brain Development.
Interventional study. This study will evaluate the safety and effectiveness of taking choline supplements during pregnancy, and whether choline supplementation has an effect on infant development. Ages 18-45. Location in Aurora, CO.
- Identifying the Role of Oxytocin and Vasopressin in the Functioning of Neurocognitive Systems Involved in Mood Disorders.
Evaluation study. The goal of this protocol, broadly stated, is to use targeted manipulations with intranasally administered oxytocin (OT) and arginine vasopressin (AVP) in conjunction with neurocognitive and neuroimaging paradigms to evaluate claims that OT and AVP inhibit and facilitate, respectively, the effective processing of aversive signals. Ages 20-40. Location in Bethesda, MD.
- Attention and Visual Perception.
Evaluation study. The NIMH is conducting studies aimed at gaining a better understanding of the areas of the brain that are involved in different types of mental processes. Ages 18-80. Location in Bethesda, MD.
- MRS Measurement of Glutamate and GABA Metabolism in Brain.
Interventional study. This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of [13]C as it is naturally metabolized from glucose to specific chemical transmitters. Ages 18-65. Location in Bethesda, MD.
- Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome Study.
Evaluation study. Velocardiofacial syndrome, also known as 22q11.2 syndrome or DiGeorge syndrome, has been associated with many features such as a cleft palate, heart defects, and learning, speech and feeding problems. Ages 18-50. Location in Bethesda, MD.
- Investigating the Role of Serotonin in Emotional Processing Through the Use of Tryptophan Depletion.
Evaluation study. This study will examine the role of serotonin function in the brain. Ages 20-50. Location in Bethesda, MD.
- A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder.
Interventional study. This study will compare the medications fluoxetine (Prozac®) and divalproex (Depakote®) for the treatment of aggressive behavior in individuals with Intermittent Explosive Disorder (IED). Ages 21-55. Location in Chicago, IL.
- Effect of Hydrocortisone on the Brain.
Evaluation study. The purpose of this study is to use brain imaging technology to examine the effect of the hormone hydrocortisone on the brain's response to various facial expressions. Ages 18-50. Location in Bethesda, MD.
- Psychopharmacology of Fear-Potentiated Startle in Humans.
Evaluation study. The purpose of this study is to understand the effects of the drug alprazolam (Xanax ) on anxiety. Ages 18-45. Location in Bethesda, MD.
- PET Scanning in Parkinson's Disease.
Evaluation study. This is an in vivo positron emission tomography (PET) study of regional cerebral dopamine neurochemistry and blood flow in normal volunteers, persons with Parkinson's disease (both familial and sporadic), and those with schizophrenia spectrum disorders. Ages 18 and over. Location in Bethesda, MD.
- Adolescence, Puberty, and Emotion Regulation.
Evaluation study. The purpose of this study is to use brain imaging technology to compare how the brains of adolescents and adults are activated during tasks that involve emotional responses. Ages 9-35. Location in Bethesda, MD.
- The Effects of Dextroamphetamine on Brain Function.
Evaluation study. The purpose of this study is to determine the effects of the drug dextroamphetamine on the brain function and mood of healthy volunteers. Ages 18-45. Location in Bethesda, MD.
- The Effects of Reproductive Hormones on Mood and Behavior.
Evaluation study. This study evaluates the effects of estrogen and progesterone on mood, the stress response, and brain function in healthy women. Ages 18-55. Location in Bethesda, MD.
- Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children.
Evaluation study. Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. Location in Bethesda, MD.
- Studies of Blood Flow to the Brain During Thought.
Evaluation study. The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks. Ages 18-65. Locations in Baltimore, MD; Bethesda, MD.
