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Adults: Bipolar Disorder

Join a Research Study: Enrolling nationally from around the country

Antidepressant (Rapid) Effects of Ketamine

If you (or someone you know) have been diagnosed with bipolar disorder, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.

If you are 18-65 years of age and have been diagnosed with bipolar disorder and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.

After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Bipolar Depression Evaluations for Medication and Brain Imaging Studies

NIH researchers seek people between the ages of 18-70 with bipolar disorder, who are currently in a depressive phase, for participation in several brain imaging and medication studies that are evaluating how experimental medications (ketamine, riluzole & scopolamine) may reduce symptoms rapidly.

Participation includes 1-4 visits, psychiatric interviews, medical history, physical exam, blood and other medical tests. Some studies are conducted on an outpatient basis, others on an inpatient basis. Participants must be free of other serious medical conditions. Research evaluations and medications are provided at no cost.

The studies are conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate.

We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs covered by NIMH. (Arrangements vary by distance and by specific study.)

After completing the study participants receive short-term follow-up care while transitioning back to a provider.

Call about your eligibility to participate. Atendemos pacientes de habla hispana.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Investigating the Genetics of Bipolar Disorder in those affected and their family members

Researchers are looking for genes that may affect a person's chances of developing bipolar disorder. You can participate in this research study if you are over 18, have a bipolar diagnosis, or have a family member with bipolar disorder.

This study includes a telephone interview (2-4 hours) and a blood sample (blood work from your physician.) The purpose of this study is to identify genes that may contribute to the development of bipolar disorder (manic depression), and related conditions. Bipolar disorder is a common and potentially life-threatening mood disorder. The tendency to develop bipolar disorder can be inherited, but this is poorly understood and probably involves multiple genes.

This study will use genetic markers to map and identify genes that contribute to bipolar disorder. Families and individuals who have the disorder are asked to contribute personal information and a blood sample to an anonymous national database. This information will aid scientists around the world who are working together to develop better treatments for this serious mood disorder.

To find out if you qualify, email NIMH or call 1-866-644-4363 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

NIMH Family Study of Health and Behavior

The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.

To find out if you qualify, email NIMH or call 1-877-250-1560 [TTY: 1-866-411-1010].