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Adults: Depression

Join a Research Study: Depression

Depression, Ketamine and Alcohol

Researchers are evaluating rapid antidepressant effects in the brain. This inpatient study is enrolling eligible adults, ages 21 to 65, who are free of other serious medical conditions, for 4-7 weeks as research participants. Procedures may include tapering off antidepressants, a medication-free period, two infusions of alcohol and one infusion of low-dose ketamine (an FDA-approved anesthetic), and two brain scans (MRI).

The study is conducted at the NIH Clinical Center in Bethesda, MD. There is no cost to participate and compensation is provided. This study enrolls eligible participants from across the USA. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1222].

Join a Research Study: Depression

Depression and Brain Changes in Fear and Anxiety

The purpose of this research study is to better understand how the brain and body work when a person with depression feels anxious.

Research Participation Includes: 1-3 outpatient visits, computer tasks, and exposure to unpleasant stimuli and a brain scan (functional Magnetic Resonance Imaging (fMRI).

Who Can Participate: Depressed adults between the ages of 18-50, who are free of psychiatric medications and certain medical conditions.

You may not be eligible is you are pregnant, have a pacemaker, current alcohol or substance abuse problems, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions will take up to 2.5 hours. There is no cost to participate and compensation is provided. This study does not include treatment.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate.

To find out if you qualify, email NIMH or call 1-301-451-5087 [TTY: 1-866-411-1010].

Join a Research Study: Depression

Depression Evaluations for Medication and Brain Imaging Studies

These inpatient and outpatient studies investigate the brain and experimental medications (such as ketamine and diazoxide) to rapidly reduce depressive symptoms.

Participation may include outpatient visits or inpatient stays of up to 12 weeks at the NIH Clinical Center, Bethesda, MD. Procedures may include: tapering off current psychiatric medications, a medication-free period, oral or intravenous medication versus placebo, and brain scans. Participants must be ages 18 to 70 and free of serious medical conditions.

First steps to participate include, calling NIMH, learning study details, asking about your eligibility, and consenting to participate. There is no cost to participate. These studies may enroll eligible participants from across the USA. Travel arrangements and compensation are provided.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Anxiety Disorders, Bipolar Disorder, Depression

NIMH Family Study of Health and Behavior

The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.

To find out if you qualify, email NIMH or call 1-877-250-1560 [TTY: 1-866-411-1010].

Join a Research Study: Depression

Rapid Antidepressant Effects of Ketamine

If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.

If you are 18-65 years of age and have been diagnosed with major depression (unipolar) and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.

After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Depression

Treatment-Resistant Major Depression and Diazoxide

Researchers are enrolling participants for an inpatient study to assess the effectiveness of an oral medication versus placebo to rapidly improve hard-to-treat depressive symptoms. This study can last up to 12 weeks and is conducted at the NIH Clinical Center in Bethesda, Maryland.

This research aims to see if diazoxide (an enhancer of glutamate transporter function) versus placebo can rapidly improve overall major depressive symptoms in patients with treatment-resistant Major Depressive Disorder (MDD). Other goals of the study include: evaluating diazoxide’s effect on glutamate levels in the brain, determining whether changes in brain neurochemicals correlate with antidepressant response, and examining other biomarkers of response.

Eligibility criteria include people ages 18-65, who are diagnosed with MDD, have previously failed to respond to treatment, and who are free of other serious medical conditions.

There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider. Atendemos pacientes de habla hispana.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].