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Adults: Depression

Join a Research Study: Depression

Depression and Brain Changes

The primary purpose of this study is to evaluate the changes in brain chemistry that may cause depression and compare brain changes before and after starting a selective serotonin reuptake inhibitor (SSRI).

NIH researchers seek depressed persons ages 18-55 to enroll in research. You may qualify if you are currently depressed. A psychiatrist from our research team will determine your eligibility based on your symptoms and history.

Participation includes: 2 outpatient visits of six hours each, and 10-15 outpatient visits of one hour each, over 2-3 months, treatment with one of 3 standard antidepressants,and two brain scans (PET). 

Research is conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate and compensation is provided. Travel may be reimbursed. After study completion participants receive short-term follow-up care while transitioning back to their own provider, or are referred to a mental health professional.

To find out if you qualify, email NIMH or call 1-301-435-8982 [TTY: 1-866-411-1010].

Join a Research Study: Depression

Depression and Brain Imaging

The purpose of this brain imaging study is to see if depressed individuals, ages 18 and older with Major Depressive Disorder (MDD), have increased inflammation in their brain.

The study involves four outpatient visits or a brief inpatient stay at the NIH Clinical Center in Bethesda, Maryland. Procedures include blood tests, medical evaluations, and two brain scans (PET & MRI Images). Participants do not need to stop their current medications. Those not eligible to participate include pregnant women, current smokers and individuals with serious medical conditions.

There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider. Atendemos pacientes de habla hispana.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Depression

Depression and Citalopram

The scientific aims of the study are to compare blood cell levels of the p11 protein (which affects serotonin receptors) in depressed verses non-depressed individuals. We would like to examine the effect of citalopram, a selective serotonin reuptake inhibitor, on p11 levels in relation to treatment outcome.

This is a 10-12 week outpatient research study in Bethesda, MD. Eligibility Criteria: 18 - 65 years of age; currently in an episode of Major Depressive Disorder or have never experienced depression in the past; and are otherwise medically healthy. Research evaluations and medications are provided at no cost. Local transportation can be provided. After completion of the study, NIMH will provide short-term follow-up care, and then you will return to the care of your own provider.

Atendemos pacientes de habla hispana. 

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Depression

Depression Evaluations for Medication and Brain Imaging Studies

NIH researchers seek depressed people between the ages of 18-65 for participation in several brain imaging and medication studies that are evaluating how experimental medications (ketamine, riluzole & scopolamine) may reduce symptoms rapidly. 

Participation includes 1-4 visits, psychiatric interviews, medical history, physical exam, blood and other medical tests. Some studies are conducted on an outpatient basis, others on an inpatient basis. Participants must be free of other serious medical conditions. Research evaluations and medications are provided at no cost. 

The studies are conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs covered by NIMH. (Arrangements vary by distance and by specific study.) After completing the study participants receive short-term follow-up care while transitioning back to a provider.

Call about your eligibility to participate. Atendemos pacientes de habla hispana.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Anxiety Disorders, Bipolar Disorder, Depression

NIMH Family Study of Health and Behavior

The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors. 
 

To find out if you qualify, email NIMH or call 1-877-250-1560 [TTY: 1-866-411-1010].

Join a Research Study: Depression

Rapid Antidepressant Effects of Ketamine

If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.

If you are 18-65 years of age and have been diagnosed with major depression (unipolar) and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.

After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Depression

Treatment-Resistant Major Depression and Diazoxide

Researchers are enrolling participants for an inpatient study to assess the effectiveness of an oral medication versus placebo to rapidly improve hard-to-treat depressive symptoms. This study can last up to 12 weeks and is conducted at the NIH Clinical Center in Bethesda, Maryland.

This research aims to see if diazoxide (an enhancer of glutamate transporter function) versus placebo can rapidly improve overall major depressive symptoms in patients with treatment-resistant Major Depressive Disorder (MDD). Other goals of the study include: evaluating diazoxide’s effect on glutamate levels in the brain, determining whether changes in brain neurochemicals correlate with antidepressant response, and examining other biomarkers of response.

Eligibility criteria include people ages 18-65, who are diagnosed with MDD, have previously failed to respond to treatment, and who are free of other serious medical conditions.

There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider. Atendemos pacientes de habla hispana.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].