Skip to content

Adults: Perimenopause-Related Mood Disorders

Join a Research Study: Hormone Therapy-Related Mood Symptoms, Perimenopause-Related Mood Disorders

Perimenopause: An Observational Study

This is an observational study for perimenopausal depression in women between the ages of 40 and 60. The purpose of this study is to investigate mood and behavioral changes in the time period surrounding and including menopause. Perimenopausal women with depression symptoms and a control group of healthy perimenopausal volunteers will be compared to one another to identify correlates of the occurrence of depression. Additionally, a group of younger pre-perimenopausal women with normal menstrual cycle functioning will be followed through menopause to observe a possible increase of depressive symptoms around the time of menopause. This is an observational study; volunteers who participate will not receive any new or experimental therapies.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Hormone Therapy-Related Mood Symptoms, Perimenopause-Related Mood Disorders

The Treatment of Perimenopausal Depression

The purpose of this study is to evaluate the effectiveness of two medications in treating perimenopausal-related depression. Selective estrogen receptor modulators (SERMS), such as raloxifene, and phytoestrogens, such as RimostilT, have estrogen-like properties and may be effective treatment. The effect of SERMS and phytoestrogens on mood and cognitive functioning needs to be examined in women with perimenopause-related depression.

Participants in this study will be randomly assigned to receive one of four treatments for 8 weeks. Participants will have clinic visits every 2 weeks, complete self-rating scales, give urine and blood samples and meet with the medical research staff.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].