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Adults: Schizophrenia

Join a Research Study: Schizophrenia

A Study of Schizophrenia and the Brain: A Six-month Inpatient Evaluation Study

Have you been diagnosed with schizophrenia or schizoaffective disorder? Are you between 18 and 55 years of age? Would you be willing to live at the Clinical Center on the NIH campus for six months? If so, you may be eligible to participate in a study designed to understand the neurological basis of schizophrenia and to determine which symptoms are related to the illness and which are related to the medications used to treat the illness.

This six-month study has three phases: In the first phase you will participate in many comprehensive medical, neurological, cognitive, and psychiatric evaluations. In the second phase, the research phase, you will be tapered off of your medication for about 4 weeks. In the time that your medication is discontinued, research procedures will allow investigators to distinguish the effects of the illness on the brain without the interference of the medication's effects. In the third phase, you will have the opportunity to stabilize using the treatment selected to be most helpful to you.

If you are interested in inpatient studies of shorter duration that do not require that you stop taking medication, please ask about the Tolcapone and Modafinil studies of schizophrenia and short-term memory.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Schizophrenia

Clinical Trial of Modafinil for Cognition in Schizophrenia

Are you having difficulty with your concentration? Are you between 18 and 50 years of age? If you have also received the diagnosis of schizophrenia or schizoaffective disorder, then you may be able to participate in a brief clinical trial assessing the effectiveness of a medication named modafinil on your ability to concentrate, remember, and solve problems. During the study, you will be asked to stay at the NIH Clinical Center so the effects of this medication can be carefully monitored. Modafinil will be administered along with the medication that you are currently taking. To enable us to examine how this medication affects your brain function and metabolism, you will be asked to undergo physical evaluations, no radioactive brain scans, and paper and pencil tests. This study also includes normal volunteers.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Schizophrenia

Clinical Trial of Tolcapone for Cognition in Schizophrenia

Are you having difficulty with your concentration? Are you between 18 and 50 years of age? If you have also received the diagnosis of schizophrenia or schizoaffective disorder, then you may be able to participate in a brief clinical trial assessing the effectiveness of a medication named tolcapone on your ability to concentrate, remember, and solve problems. During the study, you will be asked to stay at the NIH Clinical Center so the effects of this medication can be carefully monitored. Tolcapone will be administered along with the medication that you are currently taking. To enable us to examine how this medication affects your brain function and metabolism, you will be asked to undergo physical evaluations, no radioactive brain scans, and paper and pencil tests. This study also includes healthy volunteers.
 

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Schizophrenia

Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 3.0 Tesla MRI and Magnetoencephalography

If you have been diagnosed with schizophrenia or another neurological or neuropsychiatric disorder, you may be eligible to participate in this study. Its purpose is to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers. This study will use magnetic resonance imaging (MRI) scans to identify abnormalities in neurophysiology, neurochemistry and neuroanatomy that characterize schizophrenia and other disorders. More specifically, we hope to clarify the neuronal changes that occur in localized regions of the brain which may result in widespread, devastating consequences.

Healthy volunteers who have no history of psychiatric or major medical illness will also be enrolled in this study.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Schizophrenia

The NIMH Genetic Study of Schizophrenia

If you or someone in your family is 18 years old or older and has been diagnosed with schizophrenia or schizoaffective disorder (depressed type), you may be able to participate in a genetic study that looks for genes in families. In order for family members to participate, the person with schizophrenia must be willing and able to participate. Eligible family members participate in an interview and contribute a sample of blood for genetic analysis. If you have schizophrenia, and if possible, your sibling, you may qualify to participate in this study. There is no change in medication involved.

The study involves simple cognitive tests and some MRI scans (no radiation). All testing is completed free of charge and there is compensation for each family member's participation in the study. Travel and lodging assistance is also available.

Scientists believe that the identification of susceptibility genes is key to understanding the molecular pathways of this disease so that better treatments and preventive methods can be developed in the future.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].