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Join a Research Study: Bipolar Disorder

Antidepressant (Rapid) Effects of Ketamine

If you (or someone you know) have been diagnosed with bipolar disorder, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.

If you are 18-65 years of age and have been diagnosed with bipolar disorder and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.

After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.
 

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Schizophrenia

A Study of Schizophrenia and the Brain: A Six-month Inpatient Evaluation Study

Have you been diagnosed with schizophrenia or schizoaffective disorder? Are you between 18 and 55 years of age? Would you be willing to live at the Clinical Center on the NIH campus for six months? If so, you may be eligible to participate in a study designed to understand the neurological basis of schizophrenia and to determine which symptoms are related to the illness and which are related to the medications used to treat the illness.

This six-month study has three phases: In the first phase you will participate in many comprehensive medical, neurological, cognitive, and psychiatric evaluations. In the second phase, the research phase, you will be tapered off of your medication for about 4 weeks. In the time that your medication is discontinued, research procedures will allow investigators to distinguish the effects of the illness on the brain without the interference of the medication's effects. In the third phase, you will have the opportunity to stabilize using the treatment selected to be most helpful to you.

If you are interested in inpatient studies of shorter duration that do not require that you stop taking medication, please ask about the Tolcapone and Modafinil studies of schizophrenia and short-term memory.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Healthy Volunteers

Attention and Memory Research Study

This research study seeks to understand if two FDA-approved medications affect attention and anxiety while performing computer-based tasks.  The study involves one assessment visit and one outpatient visit. 

The study is enrolling healthy participants ages 18-50.  You may be eligible if you are medically healthy.

You may not be eligible is you are pregnant or nursing, have heart disease, neurological disease, certain mental health disorders, or any health problems that would interfere with the study or make it unsafe for you. 

Research Participation Includes: Taking one dose of a medication: either Ritalin, Inderal, or placebo (an inactive pill), and performing computer tasks under stressful conditions.

The study is conducted at the NIH Clinical Center, America’s research hospital, located on the Metro red line (Medical Center stop) in Bethesda, MD.  Parking is provided at no cost.  There is no charge for study related procedures and compensation is provided. 

First Steps to Participate in Research: Learn study details, be evaluated for eligibility, and consent to participate. Refer to study no. 14-M-0114.  Se habla español.

To find out if you qualify, email NIMH or call 1-800-411-1222 [TTY: 1-866-411-1010].

Join a Research Study: Bipolar Disorder

Bipolar Depression and Riluzole

This research study is enrolling eligible participants, ages 18-70, with Bipolar Depression whose depressive symptoms have failed to improve. The study is evaluating how riluzole (an FDA approved drug for ALS, Lou Gehrig's disease) vs. placebo affects glutamate in the brain and whether a rapid improvement in symptoms may occur.

This is an 8-week study conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate and compensation is provided. We enroll participant locally and from around the country. Travel arrangements provided and costs covered by NIMH. (Arrangements vary by distance and by specific study.) After completing the study participants receive short-term follow-up care while transitioning back to a provider. Atendemos pacientes de habla hispana.

Call about your eligibility to participate.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Bipolar Disorder

Bipolar Depression Evaluations for Medication and Brain Imaging Studies

NIH researchers seek people between the ages of 18-70 with bipolar disorder, who are currently in a depressive phase, for participation in several brain imaging and medication studies that are evaluating how experimental medications (ketamine, riluzole & scopolamine) may reduce symptoms rapidly. 

Participation includes 1-4 visits, psychiatric interviews, medical history, physical exam, blood and other medical tests. Some studies are conducted on an outpatient basis, others on an inpatient basis. Participants must be free of other serious medical conditions. Research evaluations and medications are provided at no cost. 

The studies are conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate. 

We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs covered by NIMH. (Arrangements vary by distance and by specific study.) 

After completing the study participants receive short-term follow-up care while transitioning back to a provider. 

Call about your eligibility to participate. Atendemos pacientes de habla hispana.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Healthy Volunteers

Brain and Body Responses to Stress Study

The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

Research Participation Includes: Performing computer tasks while being exposed to unpleasant stimuli.  Researchers will assess changes in heart rate, muscle activity, sweat responses, and respiration that occur during exposure to mildly unpleasant events. In addition, we will investigate cognitive changes (e.g. memory, attention) based on your task performance.

Who Can Participate: Healthy volunteers between the ages of 18-50, who have no current psychiatric illness, current drug or alcohol abuse, or major medical illness may be enrolled in this study. Volunteers cannot be pregnant and must also be free of certain medications that may interfere with the study.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. There are 1 to 4 outpatient visits.  There is no cost to participate and compensation is provided.

First Steps to Join a Study: Learn study details, be pre-screened for eligibility, and consent to participate. Se habla español.

To find out if you qualify, email NIMH or call 1-800-411-1222 [TTY: 1-866-411-1010].

Join a Research Study: Anxiety Disorders

Brain Changes in Fear and Anxiety

The purpose of these research studies is to better understand how the brain and body work in individuals with anxiety disorders.

Research Participation Includes: One outpatient testing session performing computer tasks during a brain scan (functional Magnetic Resonance Imaging (fMRI). During the session, you will be exposed to unpleasant stimuli.  Researchers will assess brain and body responses to task performance reviewing brain imaging (fMRI) and physiological changes (e.g. heart rate) that occur when participants feel anxious.

Who Can Participate: Adults between the ages of 18-50 with generalized anxiety disorder, social anxiety disorder or a panic disorder. Eligible participants must be in good physical health, not currently on any psychotropic medications or other medications that may interfere with the study, and be free of a history of any additional psychiatric disorders.

This study is conducted at the Eligible NIH Clinical Center in Bethesda, Maryland . The one testing session lasts up to 2.5 hours. There is no cost to participate and compensation is provided.

First Steps to Join a Study: Learn study details, be pre-screened for eligibility, and consent to participate.  Refer to study 02-M-0321.

To find out if you qualify, email NIMH or call 1-888-644-2694 (1-888-NIH-ANXI) [TTY: 1-866-411-1010].

Join a Research Study: Healthy Volunteers

Brain Changes in Fear and Anxiety Study

The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

Research Participation Includes: One outpatient testing session performing computer tasks during a brain scan (functional Magnetic Resonance Imaging (fMRI). During the session, you will be exposed to unpleasant stimuli.  Researchers will assess brain and body responses to task performance reviewing brain imaging (fMRI) and physiological changes (e.g. heart rate) that occur when participants feel anxious.

Who Can Participate: Healthy volunteers between the ages of 18-50, who have no current psychiatric disorder or major medical illness (such as high blood pressure) may be enrolled in this study. Volunteers with a history of past bipolar depression or psychosis may not apply.

The study is conducted at the NUH Clinical Center in Bethesda, Maryland. The one testing sessions lasts up to 2.5 hours. There is no cost to participate and compensation is provided.

First Steps to Participate in Research: Learn study details, be pre-screened for eligibility, and consent to participate. Refer to study 02-M-0321. Se habla español.

To find out if you qualify, email NIMH or call 1-800-411-1222 [TTY: 1-866-411-1010].

Join a Research Study: Autism Spectrum Disorders

Brain Imaging of Autism Biomarker

This research study seeks to detect and measure an immune biomarker in the brain. Researchers will compare the brain scans of those with Autism to those without Autism. 

The causes of autism are not known, but previous research has suggested an association between autism and immune changes in the brain. This study proposes to determine whether the emerging evidence and role of neuroimmune activation (as a biomarker in the brain) will indicate if there are greater immune changes in persons with autism.

This outpatient research study includes 2-4 outpatient visits of 2-6 hours each. There is an initial screening appointment that includes a physical examination, psychological examination, medical history, mood and behavior questions, and blood and urine tests. The research study includes a baseline MRI brain scan, a PET brain scan (with the administration of a drug that attaches to a brain protein), and a follow-up visit to provide a final blood sample. Eligibility criteria includes: adults ages 18-45; a diagnosis of Autism, Asperger Syndrome, or an Autism Spectrum Disorder; and good health (without a serious medical condition.)

There is no cost to participate. Compensation is provided for participation. Transportation may be provided.

To find out if you qualify, email NIMH or call 1-301-435-8982 [TTY: 1-866-411-1010].

Join a Research Study: HIV/AIDS-Related Issues

Brain Imaging Study for HIV Associated Thinking and Mood Disorders

This research study seeks to understand how HIV infection may cause problems with blood vessel function and contribute to thinking and mood disorders, such as early dementia and depression. Researchers will compare persons with and without HIV infection.

This study is enrolling adults ages 25 to 55, who are fluent English speakers, HIV positive and free of certain medical conditions (call to find out). Participation includes 1-5 visits, cognitive evaluations, medical history, physical exam, blood work, brain scans, and optional follow up visits every 6 months for 1-4 years.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland (Metro Redline/Medical Center). This study enrolls eligible participants locally from within 50 miles of NIH. There is no cost to participate. Compensation is provided. Transportation may be reimbursed.

The first steps to consider participating in this research are to call NIH, learn the study details, be evaluated for eligibility and consent to participate.
 

To find out if you qualify, email NIMH or call 1-800-411-1222 [TTY: 1-866-411-1010].

Join a Research Study: Schizophrenia

Clinical Trial of Modafinil for Cognition in Schizophrenia

Are you having difficulty with your concentration? Are you between 18 and 50 years of age? If you have also received the diagnosis of schizophrenia or schizoaffective disorder, then you may be able to participate in a brief clinical trial assessing the effectiveness of a medication named modafinil on your ability to concentrate, remember, and solve problems. During the study, you will be asked to stay at the NIH Clinical Center so the effects of this medication can be carefully monitored. Modafinil will be administered along with the medication that you are currently taking. To enable us to examine how this medication affects your brain function and metabolism, you will be asked to undergo physical evaluations, no radioactive brain scans, and paper and pencil tests. This study also includes normal volunteers.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Schizophrenia

Clinical Trial of Tolcapone for Cognition in Schizophrenia

Are you having difficulty with your concentration? Are you between 18 and 50 years of age? If you have also received the diagnosis of schizophrenia or schizoaffective disorder, then you may be able to participate in a brief clinical trial assessing the effectiveness of a medication named tolcapone on your ability to concentrate, remember, and solve problems. During the study, you will be asked to stay at the NIH Clinical Center so the effects of this medication can be carefully monitored. Tolcapone will be administered along with the medication that you are currently taking. To enable us to examine how this medication affects your brain function and metabolism, you will be asked to undergo physical evaluations, no radioactive brain scans, and paper and pencil tests. This study also includes healthy volunteers.
 

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Depression

Depression and Brain Changes

The primary purpose of this study is to evaluate the changes in brain chemistry that may cause depression and compare brain changes before and after starting a selective serotonin reuptake inhibitor (SSRI).

NIH researchers seek depressed persons ages 18-55 to enroll in research. You may qualify if you are currently depressed. A psychiatrist from our research team will determine your eligibility based on your symptoms and history.

Participation includes: 2 outpatient visits of six hours each, and 10-15 outpatient visits of one hour each, over 2-3 months, treatment with one of 3 standard antidepressants,and two brain scans (PET). 

Research is conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate and compensation is provided. Travel may be reimbursed. After study completion participants receive short-term follow-up care while transitioning back to their own provider, or are referred to a mental health professional.

To find out if you qualify, email NIMH or call 1-301-435-8982 [TTY: 1-866-411-1010].

Join a Research Study: Depression

Depression and Citalopram

The scientific aims of the study are to compare blood cell levels of the p11 protein (which affects serotonin receptors) in depressed verses non-depressed individuals. We would like to examine the effect of citalopram, a selective serotonin reuptake inhibitor, on p11 levels in relation to treatment outcome.

This is a 10-12 week outpatient research study in Bethesda, MD. Eligibility Criteria: 18 - 65 years of age; currently in an episode of Major Depressive Disorder or have never experienced depression in the past; and are otherwise medically healthy. Research evaluations and medications are provided at no cost. Local transportation can be provided. After completion of the study, NIMH will provide short-term follow-up care, and then you will return to the care of your own provider.

Atendemos pacientes de habla hispana. 

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Depression

Depression and Scopolamine

NIMH researchers are conducting an inpatient or outpatient treatment study to look at how a currently FDA-approved drug, Scopolamine, which is used for motion sickness, can help with depression. In this study, the drug is given intravenously over 7-sessions.

Eligibility criteria: Ages 18-55, currently depressed, not taking medications for at least 3 weeks.

After completion of the study, NIMH will provide short-term follow-up care, and then you will return to the care of your own provider. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States.

Atendemos pacientes de habla hispana.

To find out if you qualify, email NIMH or call 1-877-269-5586 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Depression

Depression Evaluations for Medication and Brain Imaging Studies

NIH researchers seek depressed people between the ages of 18-65 for participation in several brain imaging and medication studies that are evaluating how experimental medications (ketamine, riluzole & scopolamine) may reduce symptoms rapidly. 

Participation includes 1-4 visits, psychiatric interviews, medical history, physical exam, blood and other medical tests. Some studies are conducted on an outpatient basis, others on an inpatient basis. Participants must be free of other serious medical conditions. Research evaluations and medications are provided at no cost. 

The studies are conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs covered by NIMH. (Arrangements vary by distance and by specific study.) After completing the study participants receive short-term follow-up care while transitioning back to a provider.

Call about your eligibility to participate. Atendemos pacientes de habla hispana.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Anxiety Disorders

Generalized Anxiety Disorder and Social Anxiety Disorder: Their impact on the processing of social emotional information and instrumental learning

If you consider yourself to experience more anxiety or are shyer than those around you or have been diagnosed with generalized anxiety disorder or social anxiety disorder, you may be able to participate in this study examining how the brain responds to and analyzes emotional events.

Our goal is to understand what is special about the brain response to emotional events in people with anxiety disorders. We assess brain responses with both computer tasks and brain imaging (functional Magnetic Resonance Imaging; fMRI). Healthy volunteers who have no history of psychiatric or major medical illness will also be enrolled in this study.

To find out if you qualify, email NIMH or call 1-888-644-2694 (1-888-NIH-ANXI) [TTY: 1-866-411-1010].

Join a Research Study: Anxiety Disorders

How Cognitive Behavioral Therapy (CBT) May Change Stress Responses

This study seeks to understand how people who struggle with anxiety respond to different stressful situations, and how Cognitive Behavioral Therapy (CBT) may change these responses.

Research Participation Includes: Physical and neurological exams, EKG, blood and urine tests and stress-inducing tasks. Optional Cognitive Behavioral Therapy (CBT) is conducted over 8 outpatient group visits of 1.5 hours each.

Who Can Participate: The study is enrolling adults, aged 18-60, with generalized anxiety disorder, social anxiety disorder or a panic disorder.  Eligibility includes fluency in English, in good health, free of certain medications and without recent drug or alcohol abuse (6 months).

Enrollees will participate in 2-4 outpatient procedural visits of 1.5 hours each and 8 CBT sessions. There is no cost to participate and compensation is provided. Research is conducted at the NIH Clinical Center, Bethesda, MD.

First Steps to Join a Study: Call or email us at 1-888-644-2694 (1-888-NIH-ANXI), TTY: 1-866-411-1010, or anxiety@mail.nih.gov. Learn study details, be pre-screened for eligibility, and consent to participate. Refer to study 03-M-0093.

 
 

To find out if you qualify, email NIMH or call 1-888-644-2694 (1-888-NIH-ANXI) [TTY: 1-866-411-1010].

Join a Research Study: Bipolar Disorder

Investigating the Genetics of Bipolar Disorder in those affected and their family members

Researchers are looking for genes that may affect a person's chances of developing bipolar disorder. You can participate in this research study if you are over 18, have a bipolar diagnosis, or have a family member with bipolar disorder. 

This study includes a telephone interview (2-4 hours) and a blood sample (blood work from your physician.) The purpose of this study is to identify genes that may contribute to the development of bipolar disorder (manic depression), and related conditions. Bipolar disorder is a common and potentially life-threatening mood disorder. The tendency to develop bipolar disorder can be inherited, but this is poorly understood and probably involves multiple genes.

This study will use genetic markers to map and identify genes that contribute to bipolar disorder. Families and individuals who have the disorder are asked to contribute personal information and a blood sample to an anonymous national database. This information will aid scientists around the world who are working together to develop better treatments for this serious mood disorder.
 

To find out if you qualify, email NIMH or call 1-866-644-4363 [TTY: 1-866-411-1010].

Join a Research Study: Healthy Volunteers

Investigation of how genes and the environment affect brain development

Researchers are enrolling healthy participants, ages 6 and up. This brain development study takes place at the NIH Clinical Center in Bethesda, Maryland. Research participation includes: Brain imaging, blood draw & skin biopsy, and learning & memory tests, and two outpatient visits.

There is no cost to participate and compensation is provided. Transportation assistance/reimbursement is provided. Parental permission is required for minors 18 and under.

To find out if you qualify, email NIMH or call 1-301-496-3334 [TTY: 1-866-411-1010].

Join a Research Study: Anxiety Disorders, Bipolar Disorder, Depression

NIMH Family Study of Health and Behavior

The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors. 
 

To find out if you qualify, email NIMH or call 1-877-250-1560 [TTY: 1-866-411-1010].

Join a Research Study: Hormone Therapy-Related Mood Symptoms, Perimenopause-Related Mood Disorders

Perimenopause: An Observational Study

This is an observational study for perimenopausal depression in women between the ages of 40 and 60. The purpose of this study is to investigate mood and behavioral changes in the time period surrounding and including menopause. Perimenopausal women with depression symptoms and a control group of healthy perimenopausal volunteers will be compared to one another to identify correlates of the occurrence of depression. Additionally, a group of younger pre-perimenopausal women with normal menstrual cycle functioning will be followed through menopause to observe a possible increase of depressive symptoms around the time of menopause. This is an observational study; volunteers who participate will not receive any new or experimental therapies.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Phantom Limb Pain

Phantom Limb Pain Research Study

Many amputees experience pain in their missing limb (often called phantom limb pain). One treatment for phantom limb pain is mirror therapy where the amputee views their moving intact limb in a mirror, making it seem as if it is the missing limb.

We are recruiting participants with an amputated limb to come to our main campus in Bethesda, MD, to participate in a brain imaging study during the course of mirror therapy. The goal of this study is to understand how the mirror therapy works: what parts of the brain are affected by the amputation, and how does the mirror therapy reverse those changes. Participants must be 18-75 years of age with a single amputated limb (not arising from diabetes). The study will require up to four visits to the campus, and participants will be reimbursed for their time participating in the study.

To find out if you qualify, email NIMH or call 1-301-402-7511 [TTY: 1-866-411-1010].

Join a Research Study: Premenstrual Syndrome (PMS)/Premenstrual Dysphoric Disorder (PMDD)

PMS: Researching the Possible Causes

If you are a woman between 18 and 45 who experiences premenstrual syndrome (PMS), you may be eligible to help researchers investigate what causes it. This study explores possible causes of PMS by using a medication to stop the menstrual cycle temporarily. After the menstrual cycle is stopped, researchers will add back either estrogen or progesterone. The purpose of this study is to examine the influence of estrogen and progesterone on mood and behavior in women with PMS. Imaging tests will be conducted and the role of serotonin will also be examined.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Premenstrual Syndrome (PMS)/Premenstrual Dysphoric Disorder (PMDD)

PMS: Studying the Possible Causes

If you are a woman between 18 and 50 who experiences premenstrual syndrome (PMS), you may be eligible to help researchers investigate what causes it. This study explores possible causes of PMS by using a medication to stop the menstrual cycle temporarily. After the menstrual cycle is stopped, researchers will add back, in sequence, estrogen, and progesterone. The purpose of this study is to examine the influence of estrogen and progesterone on mood and behavior in women with PMS.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Premenstrual Syndrome (PMS)/Premenstrual Dysphoric Disorder (PMDD)

PMS Evaluation Study

The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS).Women between the ages of 18 and 50 who experience PMS symptoms will be asked to complete clinical interviews, self-rating scales, and evaluations of mood. Your participation in this study will help researchers determine if you are eligible to participate in additional studies exploring the causes of, and treatment for PMS.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Anxiety Disorders

Predictability and Aversive Expectancies in Anxiety Disorders

This study seeks to understand how people who struggle with anxiety respond to different stressful situations. Basic research has identified biological processes that play a key role in fear and anxiety. The present study examines such processes across people with varying levels of anxiety

Research Participation Includes: Exposure to mildly unpleasant events while you complete a computer task. Researchers will assess changes in heart rate, muscle activity, sweat responses and respiration. Participation may also include assessments of your memory and attention span.

Who Can Participate in this Study: This study is enrolling adults, aged 18-60, with generalized anxiety disorder, social anxiety disorder or a panic disorder. Eligible participants must be in good physical health, may not be currently on any psychotropic medications or other medications that may interfere with the study, and free of a history of any additional psychiatric disorders.

This study is conducted at the NIH Clinical Center in Bethesda, Maryland. There are several outpatient study visits up to four hours each.

First Steps to Join a Study:  Learn study details, be pre-screened for eligibility, and consent to participate. Refer to study 03-M-0093.

To find out if you qualify, email NIMH or call 1-888-644-2694 (1-888-NIH-ANXI) [TTY: 1-866-411-1010].

Join a Research Study: Depression

Rapid Antidepressant Effects of Ketamine

If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.

If you are 18-65 years of age and have been diagnosed with major depression (unipolar) and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.

After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Schizophrenia

Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 3.0 Tesla MRI and Magnetoencephalography

If you have been diagnosed with schizophrenia or another neurological or neuropsychiatric disorder, you may be eligible to participate in this study. Its purpose is to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers. This study will use magnetic resonance imaging (MRI) scans to identify abnormalities in neurophysiology, neurochemistry and neuroanatomy that characterize schizophrenia and other disorders. More specifically, we hope to clarify the neuronal changes that occur in localized regions of the brain which may result in widespread, devastating consequences.

Healthy volunteers who have no history of psychiatric or major medical illness will also be enrolled in this study.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Schizophrenia

The NIMH Genetic Study of Schizophrenia

If you or someone in your family is 18 years old or older and has been diagnosed with schizophrenia or schizoaffective disorder (depressed type), you may be able to participate in a genetic study that looks for genes in families. In order for family members to participate, the person with schizophrenia must be willing and able to participate. Eligible family members participate in an interview and contribute a sample of blood for genetic analysis. If you have schizophrenia, and if possible, your sibling, you may qualify to participate in this study. There is no change in medication involved.

The study involves simple cognitive tests and some MRI scans (no radiation). All testing is completed free of charge and there is compensation for each family member's participation in the study. Travel and lodging assistance is also available.

Scientists believe that the identification of susceptibility genes is key to understanding the molecular pathways of this disease so that better treatments and preventive methods can be developed in the future.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Hormone Therapy-Related Mood Symptoms, Perimenopause-Related Mood Disorders

The Treatment of Perimenopausal Depression

The purpose of this study is to evaluate the effectiveness of two medications in treating perimenopausal-related depression. Selective estrogen receptor modulators (SERMS), such as raloxifene, and phytoestrogens, such as RimostilT, have estrogen-like properties and may be effective treatment. The effect of SERMS and phytoestrogens on mood and cognitive functioning needs to be examined in women with perimenopause-related depression.

Participants in this study will be randomly assigned to receive one of four treatments for 8 weeks. Participants will have clinic visits every 2 weeks, complete self-rating scales, give urine and blood samples and meet with the medical research staff.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: HIV/AIDS-Related Issues

Thinking and Memory Problems in People With HIV

This research study seeks to understand how the HIV infection affects the brain, moods, memory, thinking and concentration. Researchers will evaluate the relationship among brain inflammation, protein function and MND; and how HIV infection may cause problems with blood vessel function and contribute to thinking and mood disorders, such as early dementia and depression. Researchers will compare persons with and without HIV infection.

This study is enrolling adults ages 18 to 61, who are fluent English speakers and HIV positive and free of certain medical conditions (call to find out). Participation includes 1-4 (or 5) visits, cognitive evaluations, medical history, physical exam, blood work, and brain scans.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. This study enrolls eligible participants locally from within 50 miles of NIH. There is no cost to participate. Compensation is provided. Transportation may be reimbursed.

The first steps to consider participating in this research are to call NIMH, learn the study details, be evaluated for eligibility and consent to participate.

To find out if you qualify, email NIMH or call 1-800-411-1222 [TTY: 1-866-411-1010].

Join a Research Study: Depression

Treatment-Resistant Major Depression and Diazoxide

Researchers are enrolling participants for an inpatient study to assess the effectiveness of an oral medication versus placebo to rapidly improve hard-to-treat depressive symptoms. This study can last up to 12 weeks and is conducted at the NIH Clinical Center in Bethesda, Maryland.

This research aims to see if diazoxide (an enhancer of glutamate transporter function) versus placebo can rapidly improve overall major depressive symptoms in patients with treatment-resistant Major Depressive Disorder (MDD). Other goals of the study include: evaluating diazoxide’s effect on glutamate levels in the brain, determining whether changes in brain neurochemicals correlate with antidepressant response, and examining other biomarkers of response.

Eligibility criteria include people ages 18-65, who are diagnosed with MDD, have previously failed to respond to treatment, and who are free of other serious medical conditions.

There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider. Atendemos pacientes de habla hispana.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Postpartum Depression (PPD)

Women with a History of Postpartum Depression: The Effects of Hormones in Postpartum Mood Disorders

If you have ever suffered from postpartum depression (PPD) following childbirth, we would like you to call for information about participation in our study. The study is designed to determine if your PPD was caused by hormonal changes during or after pregnancy. This study will replicate a hormonal state of pregnancy and the 6-week period following delivery. Mood symptoms and hormone levels will be measured throughout the study.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Postpartum Depression (PPD)

Women with Postpartum Depression: A Treatment Study

If you think you may currently have postpartum depression (PPD) following the birth of a child within the past six months, you may want to consider participation in this study. The purpose of this study is to evaluate the effectiveness of estrogen in treating women with postpartum depression (PPD). You will be screened by our medical staff over the phone and in person to determine if you are eligible for the study. If eligible, you will be randomly assigned to wear skin patches containing either estradiol or placebo (a patch with no active ingredient) for 6 weeks. You will complete mood-rating forms, give urine and blood samples and meet with the medical team throughout the study.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Postpartum Depression (PPD)

Women with PPD : An Observational Study

This is an observational study for postpartum depression (PPD) This study is for three different groups of women: those who recently gave birth and have mild to moderately severe PDD (Group 1), women who recently gave birth and do not have PDD (Group 2), and those who are currently pregnant and experienced an episode of PDD with a previous birth (Group 3). The purpose of this study is to explore the relationship between mood and hormones in women with postpartum depression (PPD). This is an observational study; volunteers who participate will not receive any new or experimental therapies.

If eligible for the study, you will be interviewed about your moods, behaviors, and medical status during and immediately following your last pregnancy. You will complete self-rating scales and some women will be asked to participate in interviews, psychological tests, blood tests and urine samples. You will also participate in genetic studies which examines the role genes have in hormone related mood disorders, including PPD. A genetics test involves completing a questionnaire and providing a simple blood sample. Family members may also participate.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].