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Join a Research Study: Enrolling nationally from around the country

A Study of Schizophrenia and the Brain: A Six-month Inpatient Evaluation Study

Have you been diagnosed with schizophrenia or schizoaffective disorder? Are you between 18 and 55 years of age? Would you be willing to live at the Clinical Center on the NIH campus for six months? If so, you may be eligible to participate in a study designed to understand the neurological basis of schizophrenia and to determine which symptoms are related to the illness and which are related to the medications used to treat the illness.

This six-month study has three phases: In the first phase you will participate in many comprehensive medical, neurological, cognitive, and psychiatric evaluations. In the second phase, the research phase, you will be tapered off of your medication for about 4 weeks. In the time that your medication is discontinued, research procedures will allow investigators to distinguish the effects of the illness on the brain without the interference of the medication's effects. In the third phase, you will have the opportunity to stabilize using the treatment selected to be most helpful to you.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Attention and Memory Research Study

This research study seeks to understand if two commonly prescribed medications affect attention and anxiety while performing computer-based tasks. The study involves one assessment visit and two outpatient visits.

The study is enrolling healthy participants ages 18-50. You may be eligible if you no current psychiatric disorder and are free of certain medical conditions.

You may not be eligible is you are pregnant or nursing, have heart disease, neurological disease, certain mental health disorders, or any health problems that would interfere with the study or make it unsafe for you.

Research Participation Includes: Taking one dose of a medication: either Ritalin, Inderal, or placebo (an inactive pill), and performing computer tasks under stressful conditions. Participation may include a brain scan (functional Magnetic Resonance Imaging (fMRI).

The study is conducted at the NIH Clinical Center, America’s research hospital, located on the Metro red line (Medical Center stop) in Bethesda, MD. Parking is provided at no cost. There is no charge for study related procedures and compensation is provided.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate. Refer to study no. 14-M-0114. Se habla español.

To find out if you qualify, email NIMH or call 1-301-451-5087 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain and Body Responses to Stress Study

The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

Research Participation Includes: 1-4 outpatient visits, computer tasks, and exposure to unpleasant stimuli. Researchers will assess changes in heart rate, muscle activity, sweat responses, and respiration.

Who Can Participate: Healthy volunteers between the ages of 18-50, who have no current psychiatric disorder and are free of certain medical conditions.

You may not be eligible if you are pregnant, have current drug or alcohol abuse, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.  

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions may take up to 3 hours. There is no cost to participate and compensation is provided.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate.

To find out if you qualify, email NIMH or call 1-301-451-5087 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain Changes in Fear and Anxiety

The purpose of these research studies is to better understand how the brain and body work in individuals with anxiety disorders.

Research Participation Includes: One outpatient testing session performing computer tasks during a brain scan (functional Magnetic Resonance Imaging (fMRI). During the session, you will be exposed to unpleasant stimuli.  Researchers will assess brain and body responses to task performance reviewing brain imaging (fMRI) and physiological changes (e.g. heart rate) that occur when participants feel anxious.

Who Can Participate: Adults between the ages of 18-50 with generalized anxiety disorder, social anxiety disorder or a panic disorder. Eligible participants must be in good physical health, not currently on any psychotropic medications or other medications that may interfere with the study, and be free of a history of any additional psychiatric disorders.

This study is conducted at the Eligible NIH Clinical Center in Bethesda, Maryland . The one testing session lasts up to 2.5 hours. There is no cost to participate and compensation is provided.

First Steps to Join a Study: Learn study details, be pre-screened for eligibility, and consent to participate.  Refer to study 02-M-0321.

To find out if you qualify, email NIMH or call 1-888-644-2694 (1-888-NIH-ANXI) [TTY: 1-866-411-1010].

Join a Research Study: Healthy Volunteers

Brain Changes in Fear and Anxiety Study

The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious.

Research Participation Includes: 1-3 outpatient visits, computer tasks, and exposure to unpleasant stimuli and a brain scan (functional Magnetic Resonance Imaging (fMRI).

Who Can Participate: Healthy volunteers between the ages of 18-50, who have no current psychiatric disorder and are free of certain medical conditions.

You may not be eligible is you are pregnant, have pacemaker, current alcohol or substance abuse problems, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.  

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions will take up to 2.5 hours. There is no cost to participate and compensation is provided.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate.

To find out if you qualify, email NIMH or call 1-301-451-5087 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Brain Function Study

This research seeks to understand how protein formation in the brain is affected in fragile X syndrome (FXS).   Researchers will measure the rate at which the brain makes proteins (protein synthesis) and may identify specific parts of the brain affected in FXS. In the future, measurement of protein synthesis in FXS may help us to develop and test new therapies.

The study enrolls eligible young men with FXS, ages 18-24, from around the world, and includes one visit, lasting several days, to the NIH Clinical Center in Bethesda, Maryland. Study Includes: Assessment by physicians, blood draws, two brain scans (PET & MRI), and possible sedation. The cost of travel, food, and lodging, are covered and include the study participant and one or two accompanying family members. Compensation is paid for your time and assistance.

Please consider enrolling your child in our clinical study of FXS.

To find out if you qualify, email NIMH or call 1-301-496-4707 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain Imaging and A Study Drugs Effects on Brain Receptors

This research study will evaluate the effects of the experimental medication ketamine on brain receptors in healthy and depressed adults. The study is enrolling healthy participants ages 18-65.  You may be eligible if you free of psychiatric disorders and certain medical conditions.

Research includes 1 to 6 weeks of outpatient procedures: a screening visit, computer tasks, rating scales, neurological testing, two intravenous infusions, a blood draw, brain scans (MEG & fMRI); and may include optional 2-4 overnight stays for a sleep study.

First Steps to Participate include, calling NIMH, learning study details, asking about your eligibility, and consenting to participate.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

The purpose of this study is to understand brain development during childhood and brain changes with aging. We will look at brain changes and development in healthy adults and children. We will also look at brain changes and development in people with different developmental disorders, including sex chromosome variations.

Previous studies have shown that parts of the brain develop at different times. They have also shown that brain development can be different in people with various diseases. However, we do not fully understand normal brain development and aging. We do not know how it differs in people with certain illnesses that affect thinking and behavior. We are just starting to understand how genes can affect brain development. This study examines the relationship between genes, brain development, and behavior throughout life.  Participants have a research testing visit at the start of the study, and again every 2 years. We will use tests including brain imaging with magnetic resonance imaging (MRI). We will also use physical and psychological examination and evaluation, and genetic testing. We may also ask you to have a skin biopsy, which is described in a separate consent form. We hope that a better understanding of brain development may lead to improved prevention and treatment of mental and behavioral disorders in the future.

This study includes people in good physical health, who are over 3 years old. People in this study may be without any known psychiatric/medical conditions, or may have known conditions such as Sex Chromosome Variation, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and ADHD.

In this part of the study we are currently enrolling healthy volunteers 5-25 years old without current or past psychiatric or neurological diagnoses.

Healthy Volunteers will have an initial visit lasting about 6 hours and will be invited to return every two years. Procedures include a physical examination, a blood draw, an MRI scan of the brain, and cognitive tests of thinking, memory, and attention.  We may also ask you to have a skin biopsy.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland (just outside Washington, D.C. There is no cost to participate in this outpatient visit and compensation is provided. Children must have parental permission to participate.

To find out if you qualify, email NIMH or call 1-301-435-4516 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

The purpose of this study is to understand brain development during childhood and brain changes with aging. We will look at brain changes and development in healthy adults and children. We will also look at brain changes and development in people with different developmental disorders, including Turner Syndrome.

Previous studies have shown that parts of the brain develop at different times. They have also shown that brain development can be different in people with various diseases. However, we do not fully understand normal brain development and aging. We do not know how it differs in people with certain illnesses that affect thinking and behavior. We are just starting to understand how genes can affect brain development. This study examines the relationship between genes, brain development, and behavior throughout life. Participants have a research testing visit at the start of the study, and again every 2 years. We will use tests including brain imaging with magnetic resonance imaging (MRI). We will also use physical and psychological examination and evaluation, and genetic testing. We may also ask you to have a skin biopsy, which is described in a separate consent form. We hope that a better understanding of brain development may lead to improved prevention and treatment of mental and behavioral disorders in the future.

This study includes people in good physical health, who are over 3 years old. People in this study may be without any known psychiatric/medical conditions, or may have known conditions such as Sex Chromosome Variation, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and ADHD.

In this part of the study we are currently enrolling participants ages 5 to 25 with Turner Syndrome.

Parents and one full same-gender sibling (5-25 years old) are also eligible to participate. Parents of 4 year olds are welcome to contact us to learn about participation when their child turns 5.

Those with Turner Syndrome and siblings will have an initial 2-day outpatient visit and will be invited to return every two years. Procedures during the visit include physical and mental health examinations, a blood draw, an MRI scan of the brain, and cognitive tests of thinking, memory, and attention. We may also ask you to have a skin biopsy. Parents will be interviewed and complete questionnaires. After the visit, we will provide a report of the research test results. 

The study is conducted at the NIH Clinical Center in Bethesda, Maryland (just outside Washington, D.C.) and accepts participants from anywhere in the world. Transportation is provided from within the USA.

Transportation, lodging, and meal allowance are included for the participant, one participating sibling, and one or two parents. There is no cost to participate in this outpatient visit and compensation is provided. Children must have parental permission to participate.

To find out if you qualify, email NIMH or call 1-301-435-4516 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

The purpose of this study is to understand brain development during childhood and brain changes with aging. We will look at brain changes and development in healthy adults and children. We will also look at brain changes and development in people with different developmental disorders, including sex chromosome variations.

Previous studies have shown that parts of the brain develop at different times. They have also shown that brain development can be different in people with various diseases. However, we do not fully understand normal brain development and aging. We do not know how it differs in people with certain illnesses that affect thinking and behavior. We are just starting to understand how genes can affect brain development. This study examines the relationship between genes, brain development, and behavior throughout life. Participants have a research testing visit at the start of the study, and again every 2 years.  We will use tests including brain imaging with magnetic resonance imaging (MRI). We will also use physical and psychological examination and evaluation, and genetic testing. We may also ask you to have a skin biopsy, which is described in a separate consent form. We hope that a better understanding of brain development may lead to improved prevention and treatment of mental and behavioral disorders in the future.

This study includes people in good physical health, who are over 3 years old. People in this study may be without any known psychiatric/medical  conditions, or may have known conditions such as Sex Chromosome Variation, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and ADHD.

In this part of the study we are currently enrolling participants ages 5 to 25 with X/Y chromosome variations, such as Klinefelter (XXY), XYY, XXX, XXYY syndromes and others.

Parents and one full same-gender sibling (5-25 years old) are also eligible to participate. Parents of 4 year olds are welcome to contact us to learn about participation when their child turns 5.

Those with X/Y chromosome variations and siblings will have an initial 2-day outpatient visit and will be invited to return every two years.  Procedures during the visits include physical and mental health examinations, a blood draw, an MRI scan of the brain, and cognitive tests of thinking, memory, and attention.  We may also ask you to have a skin biopsy. Parents will be interviewed and complete questionnaires. After the visit, we will provide a report of the research test results. 

The study is conducted at the NIH Clinical Center in Bethesda, Maryland (just outside Washington, D.C.) and accepts participants from anywhere in the world. Transportation is provided from within the USA. Transportation, lodging, and meal allowance are included for the participant, one participating sibling, and one or two parents. There is no cost to participate in this outpatient visit and compensation is provided. Children must have parental permission to participate.

To find out if you qualify, email NIMH or call 1-301-435-4516 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Brain Imaging Study for HIV Associated Thinking and Mood Disorders

This research study seeks to understand how HIV infection may cause problems with blood vessel function and contribute to thinking and mood disorders, such as early dementia and depression. Researchers will compare persons with and without HIV infection.

This study is enrolling adults ages 25 to 55, who are fluent English speakers, HIV positive and free of certain medical conditions (call to find out). Participation includes 1-5 visits, cognitive evaluations, medical history, physical exam, blood work, brain scans, and optional follow up visits every 6 months for 1-4 years.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland (Metro Redline/Medical Center). This study enrolls eligible participants locally from within 50 miles of NIH. There is no cost to participate. Compensation is provided. Transportation may be reimbursed.

The first steps to consider participating in this research are to call NIH, learn the study details, be evaluated for eligibility and consent to participate.

To find out if you qualify, email NIMH or call 1-800-411-1222 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Depression, Ketamine and Alcohol

Researchers are evaluating rapid antidepressant effects in the brain. This inpatient study is enrolling eligible adults, ages 21 to 65, who are free of other serious medical conditions, for 4-7 weeks as research participants. Procedures may include tapering off antidepressants, a medication-free period, two infusions of alcohol and one infusion of low-dose ketamine (an FDA-approved anesthetic), and two brain scans (MRI).

The study is conducted at the NIH Clinical Center in Bethesda, MD. There is no cost to participate and compensation is provided. This study enrolls eligible participants from across the USA. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1222].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Depression and Brain Changes in Fear and Anxiety

The purpose of this research study is to better understand how the brain and body work when a person with depression feels anxious.

Research Participation Includes: 1-3 outpatient visits, computer tasks, and exposure to unpleasant stimuli and a brain scan (functional Magnetic Resonance Imaging (fMRI).

Who Can Participate: Depressed adults between the ages of 18-50, who are free of psychiatric medications and certain medical conditions.

You may not be eligible is you are pregnant, have a pacemaker, current alcohol or substance abuse problems, heart disease, neurological disease, or any health problems that would interfere with the study or make it unsafe for you.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. The testing sessions will take up to 2.5 hours. There is no cost to participate and compensation is provided. This study does not include treatment.

First Steps to Participate in Research: Learn study details, ask about your eligibility, and consent to participate.

To find out if you qualify, email NIMH or call 1-301-451-5087 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Depression Evaluations for Medication and Brain Imaging Studies

These inpatient and outpatient studies investigate the brain and experimental medications (such as ketamine and diazoxide) to rapidly reduce depressive symptoms.

Participation may include outpatient visits or inpatient stays of up to 12 weeks at the NIH Clinical Center, Bethesda, MD. Procedures may include: tapering off current psychiatric medications, a medication-free period, oral or intravenous medication versus placebo, and brain scans. Participants must be ages 18 to 70 and free of serious medical conditions.

First steps to participate include, calling NIMH, learning study details, asking about your eligibility, and consenting to participate. There is no cost to participate. These studies may enroll eligible participants from across the USA. Travel arrangements and compensation are provided.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

fMRI Spatial Context and Fear Conditioning

The purpose of these research studies is to better understand how the brain and body work in individuals with anxiety disorders.

Research Participation Includes: One outpatient testing session playing a video game during a brain scan (functional Magnetic Resonance Imaging (fMRI). During the session, you will be exposed to unpleasant stimuli. Researchers will assess brain and body responses to task performance reviewing brain imaging (fMRI) and physiological changes (e.g. heart rate) that occur when participants feel anxious.

Who Can Participate: Adults between the ages of 18-50 with generalized anxiety disorder, social anxiety disorder, post-traumatic stress disorder, or a panic disorder. Eligible participants must be in good physical health, and a medication-free period is required to participate in the study.

This outpatient study is conducted at the NIH Clinical Center in Bethesda, Maryland. The one testing session lasts up to 3 hours. First steps to participate include, calling NIMH, learning study details, asking about your eligibility, and consenting to participate. There is no cost to participate and compensation is provided.

To find out if you qualify, email NIMH or call 1-888-644-2694 (1-888-NIH-ANXI) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Generalized Anxiety Disorder and Social Anxiety Disorder: Their impact on the processing of social emotional information and instrumental learning

If you consider yourself to experience more anxiety or are shyer than those around you or have been diagnosed with generalized anxiety disorder or social anxiety disorder, you may be able to participate in this study examining how the brain responds to and analyzes emotional events.

Our goal is to understand what is special about the brain response to emotional events in people with anxiety disorders. We assess brain responses with both computer tasks and brain imaging (functional Magnetic Resonance Imaging; fMRI). Healthy volunteers who have no history of psychiatric or major medical illness will also be enrolled in this study.

To find out if you qualify, email NIMH or call 1-888-644-2694 (1-888-NIH-ANXI) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

How Cognitive Behavioral Therapy (CBT) May Change Stress Responses

This study seeks to understand how people who struggle with anxiety respond to different stressful situations, and how Cognitive Behavioral Therapy (CBT) may change these responses.

Research Participation Includes: Physical and neurological exams, EKG, blood and urine tests and stress-inducing tasks. Optional Cognitive Behavioral Therapy (CBT) is conducted over 8 outpatient group visits of 1.5 hours each.

Who Can Participate: The study is enrolling adults, aged 18-60, with generalized anxiety disorder, social anxiety disorder or a panic disorder.  Eligibility includes fluency in English, in good health, free of certain medications and without recent drug or alcohol abuse (6 months).

Enrollees will participate in 2-4 outpatient procedural visits of 1.5 hours each and 8 CBT sessions. There is no cost to participate and compensation is provided. Research is conducted at the NIH Clinical Center, Bethesda, MD.

First Steps to Join a Study: Call or email us at 1-888-644-2694 (1-888-NIH-ANXI), TTY: 1-866-411-1010, or anxiety@mail.nih.gov. Learn study details, be pre-screened for eligibility, and consent to participate. Refer to study 03-M-0093.

To find out if you qualify, email NIMH or call 1-888-644-2694 (1-888-NIH-ANXI) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Investigating the Genetics of Bipolar Disorder in those affected and their family members

Researchers are looking for genes that may affect a person's chances of developing bipolar disorder. You can participate in this research study if you are over 18, have a bipolar diagnosis, or have a family member with bipolar disorder.

This study includes a telephone interview (2-4 hours) and a blood sample (blood work from your physician.) The purpose of this study is to identify genes that may contribute to the development of bipolar disorder (manic depression), and related conditions. Bipolar disorder is a common and potentially life-threatening mood disorder. The tendency to develop bipolar disorder can be inherited, but this is poorly understood and probably involves multiple genes.

This study will use genetic markers to map and identify genes that contribute to bipolar disorder. Families and individuals who have the disorder are asked to contribute personal information and a blood sample to an anonymous national database. This information will aid scientists around the world who are working together to develop better treatments for this serious mood disorder.

To find out if you qualify, email NIMH or call 1-866-644-4363 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

NIMH Family Study of Health and Behavior

The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.

To find out if you qualify, email NIMH or call 1-877-250-1560 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Perimenopause: An Observational Study

This is an observational study for perimenopausal depression in women between the ages of 40 and 60. The purpose of this study is to investigate mood and behavioral changes in the time period surrounding and including menopause. Perimenopausal women with depression symptoms and a control group of healthy perimenopausal volunteers will be compared to one another to identify correlates of the occurrence of depression. Additionally, a group of younger pre-perimenopausal women with normal menstrual cycle functioning will be followed through menopause to observe a possible increase of depressive symptoms around the time of menopause. This is an observational study; volunteers who participate will not receive any new or experimental therapies.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Phantom Limb Pain Research Study

Many amputees experience pain in their missing limb (often called phantom limb pain). One treatment for phantom limb pain is mirror therapy where the amputee views their moving intact limb in a mirror, making it seem as if it is the missing limb.

We are recruiting participants with an amputated limb to come to our main campus in Bethesda, MD, to participate in a brain imaging study during the course of mirror therapy. The goal of this study is to understand how the mirror therapy works: what parts of the brain are affected by the amputation, and how does the mirror therapy reverse those changes. Participants must be 18-75 years of age with a single amputated limb (not arising from diabetes). The study will require up to four visits to the campus, and participants will be reimbursed for their time participating in the study.

To find out if you qualify, email NIMH or call 1-301-402-7511 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

PMS: Studying the Possible Causes

If you are a woman between 18 and 50 who experiences premenstrual syndrome (PMS), you may be eligible to help researchers investigate what causes it. This study explores possible causes of PMS by using a medication to stop the menstrual cycle temporarily. After the menstrual cycle is stopped, researchers will add back, in sequence, estrogen, and progesterone. The purpose of this study is to examine the influence of estrogen and progesterone on mood and behavior in women with PMS.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

PMS Evaluation Study

The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS).Women between the ages of 18 and 50 who experience PMS symptoms will be asked to complete clinical interviews, self-rating scales, and evaluations of mood. Your participation in this study will help researchers determine if you are eligible to participate in additional studies exploring the causes of, and treatment for PMS.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Predictability and Aversive Expectancies in Anxiety Disorders

This study seeks to understand how people who struggle with anxiety respond to different stressful situations. Basic research has identified biological processes that play a key role in fear and anxiety. The present study examines such processes across people with varying levels of anxiety

Research Participation Includes: Exposure to mildly unpleasant events while you complete a computer task. Researchers will assess changes in heart rate, muscle activity, sweat responses and respiration. Participation may also include assessments of your memory and attention span.

Who Can Participate in this Study: This study is enrolling adults, aged 18-60, with generalized anxiety disorder, social anxiety disorder or a panic disorder. Eligible participants must be in good physical health, may not be currently on any psychotropic medications or other medications that may interfere with the study, and free of a history of any additional psychiatric disorders.

This study is conducted at the NIH Clinical Center in Bethesda, Maryland. There are several outpatient study visits up to four hours each.

First Steps to Join a Study:  Learn study details, be pre-screened for eligibility, and consent to participate. Refer to study 03-M-0093.

To find out if you qualify, email NIMH or call 1-888-644-2694 (1-888-NIH-ANXI) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Rapid Antidepressant Effects of Ketamine

If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.

If you are 18-65 years of age and have been diagnosed with major depression (unipolar) and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.

After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling nationally from around the country

Suicide and the Brain

National Institute of Mental Health (NIMH) researchers seek adults 18 to 70, who have a history of attempted suicide but are not currently suicidal, for a study of suicide and brain function. Participation includes up to seven days as an inpatient at the NIH Clinical Center in Bethesda, Maryland. Procedures include blood tests, medical evaluations, brain imaging, sleep studies and psychiatric interviews. Participants do not need to stop their current medications. Compensation and transportation are provided. Pregnant women and individuals with serious medical conditions are not eligible.

There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at the NIH while transitioning back to a provider.

If you are in a crisis situation, contact your doctor's office, go to the nearest emergency room, or call 911 for emergency services. You can also call the toll-free, 24-hour hotline of the National Suicide Prevention Lifeline, 1-800-273-TALK (1-800-273-8255).  Your call will be connected to the crisis center nearest you. Trained staff can help talk you through your crisis.

 

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1222].

Join a Research Study: Enrolling nationally from around the country

The NIMH Genetic Study of Schizophrenia

If you or someone in your family is 18 years old or older and has been diagnosed with schizophrenia or schizoaffective disorder (depressed type), you may be able to participate in a genetic study that looks for genes in families. In order for family members to participate, the person with schizophrenia must be willing and able to participate. Eligible family members participate in an interview and contribute a sample of blood for genetic analysis. If you have schizophrenia, and if possible, your sibling, you may qualify to participate in this study. There is no change in medication involved.

The study involves simple cognitive tests and some MRI scans (no radiation). All testing is completed free of charge and there is compensation for each family member's participation in the study. Travel and lodging assistance is also available.

Scientists believe that the identification of susceptibility genes is key to understanding the molecular pathways of this disease so that better treatments and preventive methods can be developed in the future.

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Thinking and Memory Problems in People With HIV

This research study seeks to understand how the HIV infection affects the brain, moods, memory, thinking and concentration. Researchers will evaluate the relationship among brain inflammation, protein function and MND; and how HIV infection may cause problems with blood vessel function and contribute to thinking and mood disorders, such as early dementia and depression. Researchers will compare persons with and without HIV infection.

This study is enrolling adults ages 18 to 61, who are fluent English speakers and HIV positive and free of certain medical conditions (call to find out). Participation includes 1-4 (or 5) visits, cognitive evaluations, medical history, physical exam, blood work, and brain scans.

The study is conducted at the NIH Clinical Center in Bethesda, Maryland. This study enrolls eligible participants locally from within 50 miles of NIH. There is no cost to participate. Compensation is provided. Transportation may be reimbursed.

The first steps to consider participating in this research are to call NIMH, learn the study details, be evaluated for eligibility and consent to participate.

To find out if you qualify, email NIMH or call 1-800-411-1222 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Women with a History of Postpartum Depression: The Effects of Hormones in Postpartum Mood Disorders

If you have ever suffered from postpartum depression (PPD) following childbirth, we would like you to call for information about participation in our study. The study is designed to determine if your PPD was caused by hormonal changes during or after pregnancy. This study will replicate a hormonal state of pregnancy and the 6-week period following delivery. Mood symptoms and hormone levels will be measured throughout the study.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Women with Postpartum Depression: A Treatment Study

If you think you may currently have postpartum depression (PPD) following the birth of a child within the past six months, you may want to consider participation in this study. The purpose of this study is to evaluate the effectiveness of estrogen in treating women with postpartum depression (PPD). You will be screened by our medical staff over the phone and in person to determine if you are eligible for the study. If eligible, you will be randomly assigned to wear skin patches containing either estradiol or placebo (a patch with no active ingredient) for 6 weeks. You will complete mood-rating forms, give urine and blood samples and meet with the medical team throughout the study.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

Women with PPD : An Observational Study

This is an observational study for postpartum depression (PPD) This study is for three different groups of women: those who recently gave birth and have mild to moderately severe PPD (Group 1), women who recently gave birth and do not have PPD (Group 2), and those who are currently pregnant and experienced an episode of PPD with a previous birth (Group 3). The purpose of this study is to explore the relationship between mood and hormones in women with postpartum depression (PPD). This is an observational study; volunteers who participate will not receive any new or experimental therapies.

If eligible for the study, you will be interviewed about your moods, behaviors, and medical status during and immediately following your last pregnancy. You will complete self-rating scales and some women will be asked to participate in interviews, psychological tests, blood tests and urine samples. You will also participate in genetic studies which examines the role genes have in hormone related mood disorders, including PPD. A genetics test involves completing a questionnaire and providing a simple blood sample. Family members may also participate.

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].