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A Study of Schizophrenia and the Brain: A Six-month Inpatient Evaluation Study

Join a Research Study: Schizophrenia

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Have you been diagnosed with schizophrenia or schizoaffective disorder? Are you between 18 and 55 years of age? Would you be willing to live at the Clinical Center on the NIH campus for six months? If so, you may be eligible to participate in a study designed to understand the neurological basis of schizophrenia and to determine which symptoms are related to the illness and which are related to the medications used to treat the illness.

This six-month study has three phases: In the first phase you will participate in many comprehensive medical, neurological, cognitive, and psychiatric evaluations. In the second phase, the research phase, you will be tapered off of your medication for about 4 weeks. In the time that your medication is discontinued, research procedures will allow investigators to distinguish the effects of the illness on the brain without the interference of the medication's effects. In the third phase, you will have the opportunity to stabilize using the treatment selected to be most helpful to you.

If you are interested in inpatient studies of shorter duration that do not require that you stop taking medication, please ask about the Tolcapone and Modafinil studies of schizophrenia and short-term memory.