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Clinical Trial of Tolcapone for Cognition in Schizophrenia

Join a Research Study: Schizophrenia

To find out if you qualify, email NIMH or call 1-301-435-8970 (1-888-674-6464) [TTY: 1-866-411-1010].

Are you having difficulty with your concentration? Are you between 18 and 50 years of age? If you have also received the diagnosis of schizophrenia or schizoaffective disorder, then you may be able to participate in a brief clinical trial assessing the effectiveness of a medication named tolcapone on your ability to concentrate, remember, and solve problems. During the study, you will be asked to stay at the NIH Clinical Center so the effects of this medication can be carefully monitored. Tolcapone will be administered along with the medication that you are currently taking. To enable us to examine how this medication affects your brain function and metabolism, you will be asked to undergo physical evaluations, no radioactive brain scans, and paper and pencil tests. This study also includes healthy volunteers.