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Depression and Brain Changes

Join a Research Study: Depression

To find out if you qualify, email NIMH or call 1-301-435-8982 [TTY: 1-866-411-1010].

The primary purpose of this study is to evaluate the changes in brain chemistry that may cause depression and compare brain changes before and after starting a selective serotonin reuptake inhibitor (SSRI).

NIH researchers seek depressed persons ages 18-55 to enroll in research. You may qualify if you are currently depressed. A psychiatrist from our research team will determine your eligibility based on your symptoms and history.

Participation includes: 2 outpatient visits of six hours each, and 10-15 outpatient visits of one hour each, over 2-3 months, treatment with one of 3 standard antidepressants,and two brain scans (PET). 

Research is conducted at the NIH Clinical Center in Bethesda, Maryland. There is no cost to participate and compensation is provided. Travel may be reimbursed. After study completion participants receive short-term follow-up care while transitioning back to their own provider, or are referred to a mental health professional.