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The Treatment of Perimenopausal Depression

Join a Research Study: Hormone Therapy-Related Mood Symptoms, Perimenopause-Related Mood Disorders

To find out if you qualify, email NIMH or call 1-301-496-9576 [TTY: 1-866-411-1010].

The purpose of this study is to evaluate the effectiveness of two medications in treating perimenopausal-related depression. Selective estrogen receptor modulators (SERMS), such as raloxifene, and phytoestrogens, such as RimostilT, have estrogen-like properties and may be effective treatment. The effect of SERMS and phytoestrogens on mood and cognitive functioning needs to be examined in women with perimenopause-related depression.

Participants in this study will be randomly assigned to receive one of four treatments for 8 weeks. Participants will have clinic visits every 2 weeks, complete self-rating scales, give urine and blood samples and meet with the medical research staff.