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Principal Investigator: Bruno Averbeck

Bruno Averbeck

Chief
Unit on Learning and Decision Making
Laboratory of Neuropsychology

Photo of Bruno Averbeck

Biography

Dr. Averbeck attained a B.S. in Electrical Engineering from the University of Minnesota in 1994. After working 3 years in industry, Dr. Averbeck returned to the University of Minnesota and completed a Ph.D. in Neuroscience in 2001, working in the lab of Dr. Apostolos Georgopoulos. His thesis was titled, "Neural Mechanisms of Copying Geometrical Shapes". Following his thesis work, Dr. Averbeck carried out post-doctoral studies at the University of Rochester with Dr. Daeyeol Lee. During this period he studied neural mechanisms underlying sequential learning, coding of vocalizations and population coding. In 2006 Dr. Averbeck moved to University College London as a senior Lecturer, where he began experiments looking at the role of frontal-striatal circuits in learning, combining neurophysiology, brain imaging and patient studies. In 2009, Dr. Averbeck moved to the NIMH and established the Unit on Learning and Decision Making in the Laboratory of Neuropsychology.

Research Interests

The work in Dr. Averbeck's group focuses on understanding the role of frontal-striatal circuits, and particularly the role of dopamine in these circuits, on learning and the representation of beliefs. The lab pursues these questions by establishing links between network dynamics at the level of neuronal ensembles and behavior. The overall strategy of the work in the lab is to carry out experiments in patient groups that have disordered dopamine signaling, including patients with schizophrenia and patients with Parkinson's disease. Specific behaviors that are affected in the patient groups can then be implemented in primate models, where in-vivo experiments allow detailed examination of mechanism. For example, recent work has examined the possibility that delusions in schizophrenia are driven by a change in the way evidence is gathered to support beliefs about the state of the world. Work by our group and others has shown that patients with schizophrenia make decisions after gathering less evidence than control groups. Recent work in the lab has examined this behavior in healthy human subjects using functional neuroimaging, and identified a network of areas that are involved in the task, including the intraparietal sulcus, the insula and the ventral striatum. Subsequent experiments in monkeys will follow up these findings by examining the effects of pharmacological manipulations, which are thought to model psychosis, on behavior and neural ensemble activity within the brain areas uncovered by the functional imaging..

Selected Publications

Dynamic and static facial expressions decoded from motion-sensitive areas in the macaque monkey . Furl N, Hadj-Bouziane F, Liu N, Averbeck BB, Ungerleider LG. J Neurosci. 2012 Nov 7;32(45):15952-62. doi: 10.1523/JNEUROSCI.1992-12.2012. PMID: 23136433.

Decision making, impulsivity, and addictions: do Parkinson`s disease patients jump to conclusions? . Djamshidian A, O`Sullivan SS, Sanotsky Y, Sharman S, Matviyenko Y, Foltynie T, Michalczuk R, Aviles-Olmos I, Fedoryshyn L, Doherty KM, Filts Y, Selikhova M, Bowden-Jones H, Joyce E, Lees AJ, Averbeck BB. Mov Disord. 2012 Aug;27(9):1137-45. doi: 10.1002/mds.25105. Epub 2012 Jul 20. PMID: 22821557.

Spontaneous high-gamma band activity reflects functional organization of auditory cortex in the awake macaque . Makoto Fukushima, Richard C. Saunders, David A. Leopold, Mortimer Mishkin, Bruno B. Averbeck. Neuron. 2012 June 7; 74(5): 899–910. doi: 10.1016/j.neuron.2012.04.014 PMID: 22681693.

Action selection and action value in frontal-striatal circuits . Moonsang Seo, Eunjeong Lee, Bruno B. Averbeck. Neuron. 2012 June 7; 74(5): 947–960. doi: 10.1016/j.neuron.2012.03.037. PMID: 22681697.

Parietal cortex and insula relate to evidence seeking relevant to reward-related decisions . Furl N, Averbeck BB. J Neurosci. 2011 Nov 30;31(48):17572-82. doi: 10.1523/JNEUROSCI.4236-11.2011. PMID: 22131418.