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Principal Investigator: Jay Giedd

Jay Giedd

Chief
Section on Brain Imaging
Child Psychiatry Branch

Photo of Jay Giedd

Biography

Dr. Giedd received his M.D. from the University of North Dakota in 1986. He received his training in adult psychiatry at the Menninger Foundation in Topeka, KS, and his Child and Adolescent Psychiatry training at Duke University in Durham, NC. He is board certified in General, Child and Adolescent, and Geriatric Psychiatry. Currently, he is the Chief of the Unit on Brain Imaging in the Child Psychiatry Branch at the NIMH. His research focuses on the biological basis of cognitive, emotional and behavioral disorders.

Research Interests

Dr. Giedd's research team at the Child Psychiatry Branch of the National Institute of Mental Health seeks to use cutting edge technologies to explore the relationship between genes, brain and behavior in healthy development and in neuropsychiatric disorders of childhood onset. They conduct longitudinal neuropsychological and brain imaging studies of healthy twins and singletons as well as clinical groups such as attention-deficit/hyperactivity disorder, childhood-onset schizophrenia, and others. Over the past 20 years they have acquired over 3000 MRI scans making this the largest pediatric neuroimaging project of its kind. The lab also studies sexual dimorphism in the developing brain (especially important in child psychiatry where nearly all disorders have different ages of onsets, prevalence and symptomatology between boys and girls) by exploring clinical populations which have unusual levels of hormones (congenital adrenal hyperplasia, familial precocious puberty) or variations in the sex chromosomes (Klinefelter's syndrome, XYY, XXYY). The lab also conducts studies of monozygotic and dizygotic twins, which are beginning to unravel the relative contributions of genes and environment on a variety of developmental trajectories in the pediatric brain. The group is also involved in the development and application of techniques to analyze brain images and is actively collaborating with other imaging centers throughout the world to advance the image analysis field.

Selected Publications

Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies: implications for idiopathic language impairment and autism spectrum disorders . Lee NR, Wallace GL, Adeyemi EI, Lopez KC, Blumenthal JD, Clasen LS, Giedd JN. J Child Psychol Psychiatry. 2012 Oct;53(10):1072-81. doi: 10.1111/j.1469-7610.2012.02573.x. Epub 2012 Jul 25. PMID: 22827287.

The digital revolution and adolescent brain evolution . Giedd JN. J Adolesc Health. 2012 Aug;51(2):101-5. doi: 10.1016/j.jadohealth.2012.06.002. PMID: 22824439.

Prenatal growth in humans and postnatal brain maturation into late adolescence . Raznahan A, Greenstein D, Lee NR, Clasen LS, Giedd JN. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11366-71. doi: 10.1073/pnas.1203350109. Epub 2012 Jun 11. PMID: 22689983.

How does your cortex grow? . Raznahan A, Shaw P, Lalonde F, Stockman M, Wallace GL, Greenstein D, Clasen L, Gogtay N, Giedd JN. J Neurosci. 2011 May 11;31(19):7174-7. doi: 10.1523/JNEUROSCI.0054-11.2011. PMID: 21562281.

Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia . Alexander-Bloch AF, Gogtay N, Meunier D, Birn R, Clasen L, Lalonde F, Lenroot R, Giedd J, Bullmore ET. Front Syst Neurosci. 2010 Oct 8;4:147. doi: 10.3389/fnsys.2010.00147. PMID: 21031030.

Magnuson Clinical Center, Room 4C110, MSC 1367
Bethesda, MD 20814

Phone: +1 301 435 4517
Fax: +1 301 480 8898

jgiedd@mail.nih.gov