Principal Investigator: Karen Faith Berman
Karen Faith Berman
Section on Integrative Neuroimaging
Clinical Brain Disorders Branch
Dr. Berman is a Senior Investigator and Chief of the Section on Integrative Neuroimaging and the Clinical Brain Disorders Branch at the National Institutes of Health, NIMH Intramural Research Program. After receiving her M.D. degree at St. Louis University, she completed a medical internship at Washington University in St. Louis and had residency training in psychiatry at the University of California at San Diego. Dr. Berman also completed residency training in nuclear medicine at the NIH Warren G. Magnusen Clinical Center and is board certified in both psychiatry and nuclear medicine. She has received a number of awards, including the A.E. Bennett Award for Neuropsychiatric Research of the Society of Biological Psychiatry, the National Alliance for Research on Schizophrenia and Depression (NARSAD) Independent Investigator Award, the NIH Bench to Bedside Award, and the NIH Director’s Award for her outstanding pioneering research on Williams Syndrome. Dr. Berman’s research group conducts translational investigations, using multimodal neuroimaging to bridge the gap between neurogenetic, molecular, cellular, and system-level mechanisms of brain dysfunction and the cognitive and behavioral manifestations of neurosychiatric disorders neurodevelopmental and genetic sources such as schizophrenia and Williams syndrome, as well of other conditions impacting cognition such as normal aging. They also study the effects of gonadal steroid hormones on brain function. This body of work has been published in Nature Neuroscience, Neuron, the Journal of Clinical Investigation, the Proceedings of the National Academy of Sciences, and the Journal of Neuroscience, among others.
Dr. Berman’s group uses functional neuroimaging to map brain activity and neurochemical mechanisms associated with normal higher cognitive function as well as dysfunction in neuropsychiatric illnesses such as schizophrenia, illnesses having genetic sources of cognitive dysfunction such as Williams syndrome and other conditions impacting cognition such as normal aging. They also study the effects of gonadal steroid hormones on brain function.
The Williams syndrome chromosome 7q11.23 hemideletion confers hypersocial, anxious personality coupled with altered insula structure and function. Jabbi M, Kippenhan JS, Kohn P, Marenco S, Mervis CB, Morris CA, Meyer-Lindenberg A, Berman KF. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E860-6. doi: 10.1073/pnas.1114774109. Epub 2012 Mar 12. PMID: 22411788.
Variation in dopamine genes influences responsivity of the human reward system. Dreher JC, Kohn P, Kolachana B, Weinberger DR, Berman KF. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):617-22. doi: 10.1073/pnas.0805517106. Epub 2008 Dec 22. PMID: 19104049.
Neural correlates of genetically abnormal social cognition in Williams syndrome. Meyer-Lindenberg A, Hariri AR, Munoz KE, Mervis CB, Mattay VS, Morris CA, Berman KF. Nat Neurosci. 2005 Aug;8(8):991-3. Epub 2005 Jul 10. PMID: 16007084.
Human dorsal and ventral auditory streams subserve rehearsal-based and echoic processes during verbal working memory. Buchsbaum BR, Olsen RK, Koch P, Berman KF. Neuron. 2005 Nov 23;48(4):687-97. PMID: 16301183.
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Meyer-Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF. Nat Neurosci. 2002 Mar;5(3):267-71. PMID: 11865311.
Magnuson Clinical Center, Room 3C109, MSC 1365
Bethesda, MD 20814
Phone: +1 301 496 7603
Fax: +1 301 480 7795