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Principal Investigator: Sanford Markey, PhD

Sanford Markey, PhD

Section on Analytical Biochemistry

Laboratory of Neurotoxicology

Photo of Sanford Markey


Dr. Markey is chief of the Laboratory of Neurotoxicology of the Intramural Research Program, National Institute of Mental Health in Bethesda, Maryland. Dr. Markey received his A.B. from Bowdoin College in 1964, and his Ph.D. in Chemistry from the Massachusetts Institute of Technology in 1968. In a faculty position in Pediatrics and Pharmacology at the University of Colorado Medical Center, he developed and applied gas chromatographic-mass spectrometric-computer methods to the diagnosis of inborn errors of metabolism. Dr. Markey joined NIMH in 1974 and developed a laboratory to investigate the metabolism of small molecules important in brain biochemistry. Dr. Markey's laboratory is studying proteins in sub-cellular structures, particularly those relevant to neuronal development and synaptic function.

Research Interests

The Laboratory of Neurotoxicology conducts research to determine the biochemical events that cause neuronal injury and degeneration accompanying genetic disease, inflammation, trauma, and exposure to neurotoxic substances.

The Analytical Biochemistry Section emphasizes research that utilizes qualitative and quantitative molecular structure analyses to determine cellular responses to diseases and neurotoxins. Methods for the mass spectrometric analysis of protein structures are being improved, applied and tested in projects in proteomics. Software to aid in these studies is also being developed.

Selected Publications

The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome . Nanavati D, Austin DR, Catapano LA, Luckenbaugh DA, Dosemeci A, Manji HK, Chen G, Markey SP. J Neurochem. 2011 Nov;119(3):617-29. doi: 10.1111/j.1471-4159.2011.07424.x. Epub 2011 Sep 21. PMID: 21838781.

Effect of immunohistochemistry on molecular analysis of tissue samples: implications for microdissection technologies . Tangrea MA, Mukherjee S, Gao B, Markey SP, Du Q, Armani M, Kreitman MS, Rosenberg AM, Wallis BS, Eberle FC, Duncan FC, Hanson JC, Chuaqui RF, Rodriguez-Canales J, Emmert-Buck MR. J Histochem Cytochem. 2011 Jun;59(6):591-600. doi: 10.1369/0022155411404704. Epub 2011 Mar 23. PMID: 21430260.

A proteomic and transcriptomic approach reveals new insight into beta-methylthiolation of Escherichia coli ribosomal protein S12 . Strader MB, Costantino N, Elkins CA, Chen CY, Patel I, Makusky AJ, Choy JS, Court DL, Markey SP, Kowalak JA. Mol Cell Proteomics. 2011 Mar;10(3):M110.005199. doi: 10.1074/mcp.M110.005199. Epub 2010 Dec 17. PMID: 21169565.

MassSieve: panning MS/MS peptide data for proteins . Slotta DJ, McFarland MA, Markey SP. Proteomics. 2010 Aug;10(16):3035-9. doi: 10.1002/pmic.200900370. PMID: 20564260.

Magnuson Clinical Center, Room 3D42, MSC 1262
Bethesda, MD 20814

Phone: +1 301 496 4022
Fax: +1 301 451 5780