Principal Investigator: Yin Yao
Unit on Human Genomics
Dr. Yin Yao obtained her Ph.D. from Columbia University in New York City in 1996. After working one year as a postdoc fellow in the International Agency of Research on Cancer in Lyon, France, Dr. Yao returned to the States. She served as a Research Assistant Professor in University of Pittsburgh for one year and then took a Statistical Geneticist position at the Center for the Inherited Disease at Johns Hopkins University for two years. She then worked as a tenure-track faculty member in the Department of Epidemiology of Bloomberg School of Public Health at Johns Hopkins University between 2001 and 2007. She was promoted to Associate Professor in 2005. In 2007, Dr. Yao moved to the extramural program of NIMH to lead the program of Genetic Epidemiology while she maintained her research interest in method development. In the beginning of 2011, Dr. Yao took a position as the Chief of the Unit on Statistical Genomics at the Intramural Research Program (IRP) of NIMH.
Dr. Yao's current research interests include method development for analyzing next generation sequencing data and for data dimension reduction. She will also collaborate with both intramural and extramural scientists to apply the most effective statistical methods to analyze the emerging data sets with complex data structures, and mainly focus on mental health disorders and biomarker studies related to drug efficacy or side effects.
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, Kassem L, Park JH, Chatterjee N, Jamain S, Cheng A, Leboyer M, Muglia P, Schulze TG, Cichon S, Nöthen MM, Rietschel M; BiGS, McMahon FJ. Mol Psychiatry. 2013 Feb;18(2):195-205. doi: 10.1038/mp.2011.157. Epub 2011 Dec 20. PMID: 22182935.
Weighted pedigree-based statistics for testing the association of rare variants. Shugart YY, Zhu Y, Guo W, Xiong M. BMC Genomics. 2012 Nov 24;13(1):667. PMID: 23176082.
Detecting rare variants for quantitative traits using nuclear families. Guo W, Shugart YY. Hum Hered. 2012;73(3):148-58. doi: 10.1159/000338439. Epub 2012 Jun 12. PMID: 22699804.
Exome sequencing and the genetic basis of complex traits. Kiezun A, Garimella K, Do R, Stitziel NO, Neale BM, McLaren PJ, Gupta N, Sklar P, Sullivan PF, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Lehner T, Shugart YY, Price AL, de Bakker PI, Purcell SM, Sunyaev SR. Nat Genet. 2012 May 29;44(6):623-30. doi: 10.1038/ng.2303. PMID: 22641211.
Comprehensive Pathway-Based Association Study of DNA Repair Gene Variants and the Risk of Nasopharyngeal Carcinoma. Qin HD, Shugart YY, Bei JX, Pan QH, Chen L, Feng QS, Chen LZ, Huang W, Liu JJ, Jorgensen TJ, Zeng YX, Jia WH. Cancer Res. 2011 Apr 15;71(8):3000-8. doi: 10.1158/0008-5472.CAN-10-0469. Epub 2011 Mar 2. PMID: 21368091.
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