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Human Genetics Branch

Human Genetics Branch

human genetics branch staff

Human Genetics Branch Staff

About Us

Our mission is to determine the human genetic variation that contributes to the risk for mood and anxiety disorders such as bipolar disorder and panic disorder, so that better methods of diagnosis and treatment can be developed.

Recent Publications

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The genetic interacting landscape of 63 candidate genes in Major Depressive Disorder: an explorative study.  Lekman M, Hössjer O, Andrews P, Källberg H, Uvehag D, Charney D, Manji H, Rush JA, McMahon FJ, Moore JH, Kockum I. BioData Min. 2014 Sep 9;7:19. doi: 10.1186/1756-0381-7-19. eCollection 2014. PMID: 25279001

Common and rare variant analysis in early-onset bipolar disorder vulnerability.  Jamain S, Cichon S, Etain B, Mühleisen TW, Georgi A, Zidane N, Chevallier L, Deshommes J, Nicolas A, Henrion A, Degenhardt F, Mattheisen M, Priebe L, Mathieu F, Kahn JP, Henry C, Boland A, Zelenika D, Gut I, Heath S, Lathrop M, Maier W, Albus M, Rietschel M, Schulze TG, McMahon FJ, Kelsoe JR, Hamshere M, Craddock N, Nöthen MM, Bellivier F, Leboyer M. PLoS One. 2014 Aug 11;9(8):e104326. doi:10.1371/journal.pone.0104326. eCollection 2014. PMID: 25111785

Do participants in genome sequencing studies of psychiatric disorders wish to be informed of their results? A survey study.  Bui ET, Anderson NK, Kassem L, McMahon FJ. PLoS One. 2014 Jul 1;9(7):e101111. doi: 10.1371/journal.pone.0101111. eCollection 2014. PMID: 24983240

Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.  Woldehawariat G, Martinez PE, Hauser P, Hoover DM, Drevets WW, McMahon FJ. PLoS One. 2014 Jun 26;9(6):e99980. doi: 10.1371/journal.pone.0099980. eCollection 2014. PMID: 24968245

Variant GADL1 and response to lithium in bipolar I disorder.  Consortium on Lithium Genetics, Hou L, Heilbronner U, Rietschel M, Kato T, Kuo PH, McMahon FJ, Schulze TG. N Engl J Med. 2014 May 8;370(19):1857-9. doi: 10.1056/NEJMc1401817#SA4. No abstract available. PMID: 24806176

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease.  Kreisl WC, Lyoo CH, McGwier M, Snow J, Jenko KJ, Kimura N, Corona W, Morse CL, Zoghbi SS, Pike VW, McMahon FJ, Turner RS, Innis RB; Biomarkers Consortium PET Radioligand Project Team. Brain. 2013 Jul;136(Pt 7):2228-38. doi: 10.1093/brain/awt145. Epub 2013 Jun 17. PMID: 23775979

Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder.  Schulze TG, Akula N, Breuer R, Steele J, Nalls MA, Singleton AB, Degenhardt FA, Nöthen MM, Cichon S, Rietschel M; Bipolar Genome Study, McMahon FJ. World J Biol Psychiatry. 2014 Apr;15(3):200-8. doi: 10.3109/15622975.2012.662282. Epub 2012 Mar 9. PMID: 22404658

RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder.  Akula N, Barb J, Jiang X, Wendland JR, Choi KH, Sen SK, Hou L, Chen DT, Laje G, Johnson K, Lipska BK, Kleinman JE, Corrada-Bravo H, Detera-Wadleigh S, Munson PJ, McMahon FJ. Mol Psychiatry. 2014 Jan 7

Pharmacogenetics of antidepressants, mood stabilizers, and antipsychotics in diverse human populations.  Murphy E, McMahon FJ. Discov Med. 2013 Sep;16(87):113-22.

Race, genetic ancestry and response to antidepressant treatment for major depression.  Murphy E, Hou L, Maher BS, Woldehawariat G, Kassem L, Akula N, Laje G, McMahon FJ. Neuropsychopharmacology. 2013 Dec;38(13):2598-606.

Retention and attrition among African Americans in the STAR*D study: what causes research volunteers to stay or stray?  Murphy EJ, Kassem L, Chemerinski A, Rush AJ, Laje G, McMahon FJ. Depress Anxiety. 2013 Nov;30(11):1137-44.

Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.  Moya PR, Wendland JR, Rubenstein LM, Timpano KR, Heiman GA, Tischfield JA, King RA, Andrews AM, Ramamoorthy S, McMahon FJ, Murphy DL. Mov Disord. 2013 Aug;28(9):1263-70.

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.  Cross-Disorder Group of the Psychiatric Genomics Consortium; Genetic Risk Outcome of Psychosis (GROUP) Consortium. Lancet. 2013 Apr 20;381(9875):1371-9.

Amish revisited: Next-generation sequencing studies of psychiatric disorders among the Plain people.  Hou L, Faraci G, Chen DT, Kassem L, Schulze TG, Shugart YY, McMahon FJ. Trends Genet. 2013 Jul;29(7):412-8.

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.  GENDEP Investigators; MARS Investigators; STAR*D Investigators. Am J Psychiatry. 2013 Feb 1;170(2):207-17.

Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.  Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, Kassem L, Park JH, Chatterjee N, Jamain S, Cheng A, Leboyer M, Muglia P, Schulze TG, Cichon S, Nöthen MM, Rietschel M; BiGS, McMahon FJ, Kelsoe JR, Greenwood TA, Nievergelt CM, McKinney R, Shilling PD, Schork NJ, Smith EN, Bloss CS, Nurnberger JI Jr, Edenberg HJ, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon FJ, Chen DT, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Schulze TG. Mol Psychiatry. 2013 Feb;18(2):195-205.

A systems approach to the biology of mood disorders through network analysis of candidate genes . Detera-Wadleigh SD & Akula N;. Pharmacopsychiatr. 2011, 44 (Suppl 1): S35-42.

A network-based approach to prioritize results from genome-wide association studies.  Akula N, Baranova A, Seto D, Solka J, Nalls MA, Singleton A, Ferrucci L, Tanaka T, Bandinelli S, Cho YS, Kim YJ, Lee JY, Han BG; Bipolar Disorder Genome Study (BiGS) Consortium; Wellcome Trust Case-Control Consortium, McMahon FJ. PLoS One. 2011;6(9):e24220. Epub 2011 Sep 6.

The genetics of panic disorder.  Schumacher J, Kristensen AS, Wendland JR, Nöthen MM, Mors O, McMahon FJ. J Med Genet. 2011 Jun;48(6):361-8. doi: 10.1136/jmg.2010.086876. Epub 2011 Apr 14. Review.