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Molecular Imaging Branch

Section on Magnetic Resonance Spectroscopy

Overview

Jun Shen, Ph.D., Section Chief

Jun Shen, Ph.D., Section Chief

The Magnetic Resonance Spectroscopy Section focuses on development and application of state-of-the-art magnetic resonance spectroscopy (MRS) and imaging (MRI) technologies. It has access to a 7 Tesla and a 3 Tesla whole-body spectrometer for research on human subjects as well as an 11.7 Tesla vertical widebore spectrometer for both in vivo and in vitro studies of small rodents.

The high field strength magnets allow significant improvement in resolution and sensitivity for MRS and MRI measurements. This Section develops novel RF pulses, RF/gradient pulse sequences and sophisticated data analysis methods for studying magnetic resonance biomarkers in brain.

Using high-field MRS and MRI methods this Section conducts basic research on neurotransmission and neurotransmitter metabolism. In particular, in vivo assessment of glutamate and GABA neurotransmission and metabolism is used to explore the function and modulation of these neurotransmitters in the brain under a variety of conditions. The aim is to further our understanding of the role of these neurotransmitters and other important metabolites in psychiatric disorders.

Contact Information

Jun Shen, Ph.D.
MIB/MADP/NIMH
Building 10, 2D51A, MSC-1527
10 Center Drive
Bethesda, MD. 20892-1527
Phone: (301) 451-3408
Fax: (301) 402-3480
Email: shenj@intra.nimh.nih.gov