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Molecular Imaging Branch

Representative Publications

P. Kannan, K.R. Brimacombe, W.C. Kreisl, J.-S. Liow, S.S. Zoghbi, S. Telu, Y. Zhang, V.W. Pike, C. Halldin, M.M. Gottesman, R.B. Innis, and M.D. Hall. Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET. Proc. Natl. Acad. Sci. USA. 108: 2593–2598, 2011.

M. Fujita, C.S. Hines, S.S. Zoghbi, A.G. Mallinger, L.P. Dickstein, J.-S. Liow, Y. Zhang, V.W. Pike, W.C. Drevets, R.B. Innis, and C.A. Zarate Jr. Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder. Biol. Psych. 72: 548-554, 2012.

J. Hirvonen, W.C. Kreisl, M. Fujita, I. Dustin, S. Miranda, Y. Zhang, C. Morse, V.W. Pike, R.B. Innis, and W.H. Theodore. Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. J. Nucl. Med. 53: 234-240, 2012.

T.G. Lohith, S.S. Zoghbi, C.L. Morse, M.F. Araneta, V.N. Barth, N.A. Goebl, J.A. Tauscher, V.W. Pike, R.B. Innis, and M. Fujita. Brain and whole-body imaging of nociceptin/orphanin FQ peptide (NOP) receptors in humans using a novel PET ligand 11C-NOP-1A. J. Nucl. Med. 53: 385-392, 2012.

J. Hirvonen, P. Zanotti Fregonara, J.C. Umhau, D.T. George, D. Rallis-Frutos, C.H. Lyoo, C.-T. Li, C.S. Hines, H. Sun, G.E. Terry, C. Morse, S.S. Zoghbi, V.W. Pike, R.B. Innis, and M. Heilig. Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. Mol. Psychiatry 18: 916-921, 2013.

W.C. Kreisl, K.J. Jenko, C.S. Hines, C.H. Lyoo, W. Corona, C.L. Morse, S.S. Zoghbi, T. Hyde, J.E. Kleinman, V.W. Pike, F.J. McMahon, and R.B. Innis. A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. J. Cereb. Blood Flow Metab. 33: 53-58, 2013.

W.C. Kreisl, C.H. Lyoo, M. McGwier, J. Snow, K.J. Jenko, N. Kimura, W. Corona, C.L. Morse, S.S. Zoghbi, V.W. Pike, F.J. McMahon, R.S. Turner, R.B. Innis, and the Biomarkers Consortium PET Radioligand Project Team. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease. Brain, 136: 2228-2238, 2013

S. Shrestha, E.E. Nelson, J.-S. Liow, R. Gladding, C.H. Lyoo, P.L. Noble, C. Morse, I.D. Henter, J. Kruger, B. Zhang, S.J. Suomi, P. Svenningsson, V.W. Pike, J.T. Winslow, E. Leibenluft, D.S. Pine, and R.B Innis. Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior. Am. J. Psychiatry. Jan 31, 2014 [Epub ahead of print]