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Multimedia From 2013

Introduction to RDoC

Frame from the video Introduction to RDoC.

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Neurobiobank/Jill Bolte Taylor

Frame from the video Neurobiobank/Jill Bolte Taylor.

Jill Bolte Taylor, Ph.D., a spokesperson for the Harvard Brain Tissue Resource Center, discusses why brain donation truly is the gift of hope.

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Community-based Treatments Offset Depression Disparities

Frame from the video Community-based Treatments Offset Depression Disparities.

Depression can affect anyone, but it hits ethnic groups more heavily because the poor often have less access to quality health care. To offset this imbalance, researchers from the RAND Corporation and UCLA, and community partners from more than two dozen community agencies, compared whether evidence-based quality improvement programs, which include psychotherapies such as cognitive behavioral therapy and antidepressant medications, are better implemented through involvement of the entire community or through clinic-based programs. The findings, which show the former to be the case, are reported in two papers published online by the Journal of General Internal Medicine. Project officer and Associate Director of Dissemination and Implementation Research at the National Institute of Mental Health David Chambers, Ph.D., discusses the significance of these findings.

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Dr. Daniel Pine on Boosting Resilience to PTSD

Frame from the video Dr. Daniel Pine on Boosting Resilience to PTSD.

Dr. Daniel Pine on a NIH study that tracked Israeli soldiers through deployment to ID predictors. Study found that soldiers preoccupied with threat at the time of enlistment or with avoiding it just before deployment were more likely to develop post-traumatic stress disorder (PTSD).

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Workings of an Alzheimer’s Gene

Frame from the video Workings of an Alzheimer’s Gene  .

NIH-funded scientists have discovered a potential strategy for developing treatments to stem the disease process in Alzheimer’s disease. It’s based on unclogging removal of toxic debris that accumulates in patients’ brains, by blocking activity of a little-known regulator protein called CD33. Too much CD33 activity may promote late-onset Alzheimer’s by preventing support cells from clearing out toxic plaques. Future medications that impede CD33 activity might help prevent or treat the disorder. Dr. Thomas Lehner, director of NIMH’s Office of Genomics Research Coordination, explains the significance of the new findings.

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Dr. Michelle Freund, NIMH Project Officer on the significance of CLARITY

Frame from the video Dr. Michelle Freund, NIMH Project Officer on the significance of CLARITY.

Project officer Michelle Freund, Ph.D., of the NIMH Division of Neuroscience and Basic Behavioral Science, explains the significance of CLARITY, a breakthrough method for analyzing the brain.

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Bullying Exerts Psychiatric Effects Into Adulthood

Frame from the video Bullying Exerts Psychiatric Effects Into Adulthood.

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3-D Analysis of Intact Mouse Hippocampus CLARITY

Frame from the video 3-D Analysis of Intact Mouse Hippocampus CLARITY.

CLARITY provided this 3D view showing a thick slice of a mouse brain’s memory hub, or hippocampus. It reveals a few different types of cells: projecting neurons (green), connecting interneurons (red), and layers of support cells, or glia (blue). Conventional 2D methods require that brain tissue be thinly sliced, sacrificing the ability to analyze such intact components in relation to each other. CLARITY permits such typing of molecular and cellular components to be performed repeatedly in the same brain. Source: Kwanghun Chung, Ph.D., and Karl Deisseroth, M.D., Ph.D., Stanford University.

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3-D Tour of Intact Mouse Brain

Frame from the video 3-D Tour of Intact Mouse Brain.

CLARITY makes possible this 3D tour of an entire, intact mouse brain. It was imaged using a fluorescence technique that previously could only be performed with thinly-sliced brain tissue, making it difficult to relate micro-level findings to macro-level information about wiring and circuitry. Source: Kwanghun Chung, Ph.D., and Karl Deisseroth, M.D., Ph.D., Stanford University.

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Project Achieve Weight Loss Trial for People with Serious Mental Illness

Frame from the video Project Achieve Weight Loss Trial for People with Serious Mental Illness.

NIMH grantee Dr. Gail Daumit talks about the Project Achieve weight loss trial.

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Male Vulnerability to Maternal Stress Linked to Placental Enzyme

Frame from the video Male Vulnerability to Maternal Stress Linked to Placental Enzyme.

NIMH grantee Tracy Bale, Ph.D., of the University of Pennsylvania, discussed her line of research into how maternal stress might differentially affect the developing male brain during an interview at the 2011 Society for Neuroscience meeting.

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Five Mental Disorders Share Some of the Same Genes

Frame from the video Five Mental Disorders Share Some of the Same Genes.

Bruce Cuthbert, Ph.D., director of NIMH’s Division of Adult Translational Research, explains the significance of recent study findings for diagnosis and treatment of mental illnesses.

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NIMH’s Dr. Maura Furey on scopolamine research

Frame from the video NIMH’s Dr. Maura Furey on scopolamine research .

Dr. Maura Furey on the search for a fast acting anti-depressant.

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