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Genes Impact Suspect Cortex Areas More as Youth Mature

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Thickening of cortex areas implicated in mental illness shows increasing genetic influence as the brain develops in childhood and adolescence, NIMH researchers have found. These areas also happen to be the latest to evolve and the last to mature. The peak of genetic influence in these areas coincides with the typical age-of-onset of most mental disorders in late adolescence/early adulthood. The new findings may provide insight into the workings of gene-by-environment-by age interactions in the disorders, says Jay Giedd, M.D., of the NIMH Child Psychiatry Branch.

See: Genes Impact Suspect Cortex Areas More as Youth Mature

Credits:
Jay Giedd, M.D., Eric Schmitt, Ph.D., NIMH - MRI movies
Cristophe Lenglet, Ph.D., U. Minnesota -- DSI brain image
Van Wedeen, M.D., Harvard/MGH - DSI Animation
Brain & Behavior Research Foundation - video clip 
UCLA Laboratory of Neuro Imaging -- DSI animation from "Navigating the Connectome"

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Channel Makover Switches Off Neurons in a Flash

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Scientists have bioengineered an enhancement to a cutting edge technology that provides instant control over brain circuit activity with a flash of light. The research adds the same level of control over switching neurons off that, until now, had been limited to switching them on. What had been working through a weak pump now works through a highly responsive channel -- like going from a squirt to a gushing hose. Project officer Michelle Freund, Ph.D., of the NIMH Office of Technology Development and Coordination, explains the significance of the new findings.

See: Channel Makeover Bioengineered to Switch Off Neurons

Credits:
Karl Deisseroth, M.D. Ph.D, Stanford University
Andre Berndt, Ph.D., Stanford University
Soo Yeun Lee, Ph.D., Stanford University
Charu Ramakrishnan, Stanford University - channels image
Michelle Freund, Ph.D., NIMH

Method of the Year 2010: Optogenetics-NatureVideo  - animation
Optogenetics, Karl Deisseroth, Marina Coral, Nature Methods, 12/20/2010 - graphic

Richard Coppola, Sc.D., NIMH - MEG movie
Cristophe Lenglet, Ph.D., U. Minnesota - brain image

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NIMH Outreach Partnership Program

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The Outreach Partnership Program of the National Institute of Mental Health (NIMH) works to increase the public's access to science-based information through partnerships with national and state nonprofit organizations. With an emphasis on reaching underserved populations and promoting participation in research, the partnerships also help the NIMH understand concerns of those intended to benefit from the research the Institute supports.

NIMH Outreach Partners Program

NIMH Office of Constituency Relations and Public Liaison

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Patches of Disorganization in the Neocortex of Children with Autism

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This video has no audio. The architecture of the autistic brain is speckled with patches of abnormal neurons, according to research partially funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health. Published in the New England Journal of Medicine on March 27, 2014, this study suggests that brain irregularities in children with autism can be traced back to prenatal development.

Source: Rich Stoner, Ph.D., University of California, San Diego

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Middle Schoolers’ Field Day with the Brain

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Each year, NIMH scientists provide middle school students with a hands-on experience in understanding the workings of the brain, as part of a Brain Awareness Week program at the National Museum of Health and Medicine in Silver Spring, MD.  This video from the 2013 event features interviews with students, Museum and NIMH staffers.

For more information about the 2014 Brain Awareness Week event at the Museum, see:
Students Unlock the Mysteries of the Brain with NIH Scientists 

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Eating Disorders Myths Busted - Myth #1: You can tell by looking at someone

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Myth # 1: You can tell by looking at someone that they have an eating disorder

In this first of a series of videos, Cynthia Bulik, Ph.D., of the University of North Carolina, explains why you can't tell if someone has an eating disorder by their appearance. The video was excerpted from a talk, "Eating Disorders Essentials: Replacing Myths with Realities," presented at the NIMH Alliance for Research Progress Winter Meeting, February 7, 2014 in Rockville, MD.

See the entire "Eating Disorders Myths Busted" series.

Find more information about eating disorders.

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Eating Disorders Myths Busted - Myth #2: Families are to Blame

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Myth # 2: Families are to blame

In this second in a series of videos debunking nine myths about eating disorders, Cynthia Bulik, Ph.D., of the University of North Carolina, explains why families are not to blame.  The video was excerpted from a talk, "Eating Disorders Essentials: Replacing Myths with Realities," presented at the NIMH Alliance for Research Progress Winter Meeting, February 7, 2014 in Rockville, MD.

See the entire "Eating Disorders Myths Busted" series.

Find more information about eating disorders.

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Eating Disorders Myths Busted - Myth #3: Mothers are to Blame

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Myth # 3: Mothers are to blame

In this third of a series of videos debunking nine myths about eating disorders, Cynthia Bulik, Ph.D., of the University of North Carolina, explains why mothers are not to blame.  The video was excerpted from a talk, "Eating Disorders Essentials: Replacing Myths with Realities," presented at the NIMH Alliance for Research Progress Winter Meeting, February 7, 2014 in Rockville, MD.

See the entire "Eating Disorders Myths Busted" series.

Find more information about eating disorders.

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Eating Disorders Myths Busted - Myth #4: Eating Disorders are a Choice

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Myth # 4: Eating Disorders are a Choice

In this fourth of a series of videos debunking nine myths about eating disorders, Cynthia Bulik, Ph.D., of the University of North Carolina, explains why eating disorders are not a choice.  The video was excerpted from a talk, "Eating Disorders Essentials: Replacing Myths with Realities," presented at the NIMH Alliance for Research Progress Winter Meeting, February 7, 2014 in Rockville, MD.

See the entire "Eating Disorders Myths Busted" series.

Find more information about eating disorders.

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Eating Disorders Myths Busted - Myth #5: Eating Disorders are the province of white upper-middle class teenage girls

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Myth # 5: Eating Disorders are the province of white upper-middle class teenage girls

In this fifth of a series of videos debunking nine myths about eating disorders, Cynthia Bulik, Ph.D., of the University of North Carolina, explains that eating disorders affect women and men across the lifespan.  The video was excerpted from a talk, "Eating Disorders Essentials: Replacing Myths with Realities," presented at the NIMH Alliance for Research Progress Winter Meeting, February 7, 2014 in Rockville, MD.

See the entire "Eating Disorders Myths Busted" series.

Find more information about eating disorders.

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Eating Disorders Myths Busted - Myth #6: Eating Disorders are Benign

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Myth # 6: Eating Disorders are Benign

In this sixth in a series of videos debunking nine myths about eating disorders, Cynthia Bulik, Ph.D., of the University of North Carolina, discusses the heightened risk of suicide associated with anorexia, bulimia and binge eating disorder.  The video was excerpted from a talk, "Eating Disorders Essentials: Replacing Myths with Realities," presented at the NIMH Alliance for Research Progress Winter Meeting, February 7, 2014 in Rockville, MD.

See the entire "Eating Disorders Myths Busted" series.

Find more information about eating disorders.

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Eating Disorders Myths Busted - Myth #7: Society Alone to Blame

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Myth # 7: Society Alone is to Blame

In this seventh in a series of videos debunking nine myths about eating disorders, Cynthia Bulik, Ph.D., of the University of North Carolina, discusses evidence for gene-environment interactions in eating disorders.  The video was excerpted from a talk, "Eating Disorders Essentials: Replacing Myths with Realities," presented at the NIMH Alliance for Research Progress Winter Meeting, February 7, 2014 in Rockville, MD.

See the entire "Eating Disorders Myths Busted" series.

Find more information about eating disorders.

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Eating Disorders Myths Busted - Myth #8: Genes are Destiny

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Myth # 8: Genes Are Destiny

In this eighth in a series of videos debunking nine myths about eating disorders, Cynthia Bulik, Ph.D., of the University of North Carolina, discusses evidence for environmental factors in eating disorders.  The video was excerpted from a talk, "Eating Disorders Essentials: Replacing Myths with Realities," presented at the NIMH Alliance for Research Progress Winter Meeting, February 7, 2014 in Rockville, MD.

See the entire "Eating Disorders Myths Busted" series.

Find more information about eating disorders.

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Eating Disorders Myths Busted - Myth #9: Eating Disorders are for Life

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In this ninth in a series of videos debunking nine myths about eating disorders, Cynthia Bulik, Ph.D., of the University of North Carolina, explains that eating disorders are treatable.  The video was excerpted from a talk, "Eating Disorders Essentials: Replacing Myths with Realities," presented at the NIMH Alliance for Research Progress Winter Meeting, February 7, 2014 in Rockville, MD.

See the entire "Eating Disorders Myths Busted" series.

Find more information about eating disorders.

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Introduction to RDoC

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Neurobiobank/Jill Bolte Taylor

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Jill Bolte Taylor, Ph.D., a spokesperson for the Harvard Brain Tissue Resource Center, discusses why brain donation truly is the gift of hope.

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Community-based Treatments Offset Depression Disparities

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Depression can affect anyone, but it hits ethnic groups more heavily because the poor often have less access to quality health care. To offset this imbalance, researchers from the RAND Corporation and UCLA, and community partners from more than two dozen community agencies, compared whether evidence-based quality improvement programs, which include psychotherapies such as cognitive behavioral therapy and antidepressant medications, are better implemented through involvement of the entire community or through clinic-based programs. The findings, which show the former to be the case, are reported in two papers published online by the Journal of General Internal Medicine. Project officer and Associate Director of Dissemination and Implementation Research at the National Institute of Mental Health David Chambers, Ph.D., discusses the significance of these findings.

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Dr. Daniel Pine on Boosting Resilience to PTSD

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Dr. Daniel Pine on a NIH study that tracked Israeli soldiers through deployment to ID predictors. Study found that soldiers preoccupied with threat at the time of enlistment or with avoiding it just before deployment were more likely to develop post-traumatic stress disorder (PTSD).

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Workings of an Alzheimer’s Gene

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NIH-funded scientists have discovered a potential strategy for developing treatments to stem the disease process in Alzheimer’s disease. It’s based on unclogging removal of toxic debris that accumulates in patients’ brains, by blocking activity of a little-known regulator protein called CD33. Too much CD33 activity may promote late-onset Alzheimer’s by preventing support cells from clearing out toxic plaques. Future medications that impede CD33 activity might help prevent or treat the disorder. Dr. Thomas Lehner, director of NIMH’s Office of Genomics Research Coordination, explains the significance of the new findings.

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Dr. Michelle Freund, NIMH Project Officer on the significance of CLARITY

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Project officer Michelle Freund, Ph.D., of the NIMH Division of Neuroscience and Basic Behavioral Science, explains the significance of CLARITY, a breakthrough method for analyzing the brain.

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Bullying Exerts Psychiatric Effects Into Adulthood

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Project Achieve Weight Loss Trial for People with Serious Mental Illness

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NIMH grantee Dr. Gail Daumit talks about the Project Achieve weight loss trial.

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Male Vulnerability to Maternal Stress Linked to Placental Enzyme

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NIMH grantee Tracy Bale, Ph.D., of the University of Pennsylvania, discussed her line of research into how maternal stress might differentially affect the developing male brain during an interview at the 2011 Society for Neuroscience meeting.

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Sleep Brain Wave Key to Conquering Fear Memories

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NIMH’s Dr. Aleksandra Vicentic comments on a NIMH-funded study that has pinpointed brainwave activity, deep in the brainstem of sleeping rodents, that signals successful consolidation of safety memories that override fear memories.

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Five Mental Disorders Share Some of the Same Genes

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Bruce Cuthbert, Ph.D., director of NIMH’s Division of Adult Translational Research, explains the significance of recent study findings for diagnosis and treatment of mental illnesses.

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NIMH’s Dr. Maura Furey on scopolamine research

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Dr. Maura Furey on the search for a fast acting anti-depressant.

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A Message for Military Veterans from NIMH’s Dr. Robert Heinssen

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A soldier to soldier message for returning military veterans.

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From Clinical Trials to Classroom Commitment, NIMH Expertise Benefits Students

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One parent's goal to improve the classroom environment.

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NIMH Director Talks with NIMH Researcher about the High Priority Research Strategies of Suicide Prevention

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NIMH Director Thomas Insel discusses strategy with NIMH research Dr. Jane Pearson.

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Stanford's Hank Greely on Research Advances vs. Social Challenges

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Advances in neuroscience research may bring tough questions.

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Agent Reduces Autism-like Behaviors in Mice

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Autism-like behaviors in mice have been reduced, using an experimental agent being tested in patients for a related disorder

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Agent Reduces Repetitive Behavior in Mice

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Autism-like behaviors in mice have been reduced, using an experimental agent being tested in patients for a related disorder

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Brain’s Wiring Revealed in HD

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New brain wiring images reveal a pervasive 3D grid structure with no diagonals, say scientists funded by the National Institutes of Health.

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National Database for Autism Research

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Dr. Pamela Collins on Global Mental Health Challenges

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Dr. Pamela Collins on global mental health challenges and NIMH initiatives.

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2011 SfN Conference Highlights

The 2011 Society for Neuroscience Conference was held in Washington, DC.

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Embedded in Iraq

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Embedded reporter and NIMH discuss mental health issues for some Iraq War veterans

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Unlocking the Genetic Code

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Dr. Joel Kleinman explains when and where genes turn on in the brain

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Looking at Trauma – Long interview

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Dr. Sandro Galea, a National Institute of Mental Health grantee, talks about disasters and mental health research.

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Disasters and Mental Health Research

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Dr. Sandro Galea, a National Institute of Mental Health grantee, talks about disasters and mental health research.

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White House Champions of Change

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NIMH researchers honored with White House Champions of Change award.

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Suicide Prevention Research

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NIMH researcher Dr. Douglas Meinecke talks about critical suicide prevention research.

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Suicide Prevention and Research

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NIMH researcher Dr. Jane Pearson talks about warning signs as well as progress in suicide prevention.

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Help for Iraq and Afghanistan Veterans

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Every day, military veterans return from the intense surroundings of warfare. And some of those returning veterans come home with unique mental health challenges: a topic of discussion between NIMH Director Dr. Thomas Insel and Sergeant Todd Bowers of the organization Iraq and Afghanistan Veterans of America.

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Development of the Young Brain

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For more than twenty years, National Institute of Mental Health neuroscientist Dr. Jay Giedd has studied the development of the adolescent brain. Decades of imaging work have led to remarkable insight and a more than a few surprises.

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Stem Cell Possibilities in Autism Research

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Dr. Ricardo Dolmetsch and his colleagues have generated stem cells from children with autism allowing them to study how the brain develops in children with ASD.

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Helping Young People with ASD Find Jobs

NIH Radio: Listen to an interview with Louise Buchholz, the Content Director responsible for JobTIPS web program.

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Rethinking BPD: A Clinician’s View

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Dr. Marsha Linehan was featured in a series of lectures on Borderline Personality Disorder.

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Borderline Personality Disorder

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Recently, the National Institute of Mental Health hosted an event that focused on Borderline Personality Disorder. Featured speakers included BPD researcher Dr. Marsha Linehan as well as Amanda Wang, founder of RethinkBPD.

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Rethinking BPD: A Patient’s View

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Amanda Wang is the lead organizer of RethinkBPD, a peer-led advocacy and support group for Borderline Personality Disorder (BPD). Ms. Wang participated in a lecture series on BPD at the National Institute of Mental Health in Bethesda, Maryland. She shared her personal experience in coping with BPD as well as the objectives of RethinkBPD.

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Postpartum Depression Treatment

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Postpartum depression may be one of the most under-recognized and under-treated disorders. Yet, it impacts the lives of hundreds of thousands of new mothers. This video looks at those who are at greatest risk of postpartum depression as well as ground breaking research into treatment for PPD.

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Positive Measures to Fight Depression

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Honoring Mortimer Mishkin

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Video from the National Institute of Mental Health (NIMH) - Congratulations to Dr. Mortimer Mishkin, recipient of the National Medal of Science. Dr. Mishkin becomes the first National Institute of Mental Health intramural scientist to receive this honor. In this video Dr. Mishkin talks about his five decades of research at NIMH.

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NIMH Radio: Dr. Ron Duman of Yale University talks about ketamine research and treatment for major depression

Ketamine Research and Treatment for Major Depression.

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Prevent Suicide in Young Adults

Our NIMH partners are the eyes, ears, and legs of our research-based messages concerning the understanding and treatment of mental illnesses.

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Ben Vitiello on Treatment Options for ADHD in Children

Dr. Ben Vitiello, Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, talks about therapy and medication treatment for Attention Deficit Hyperactivity Disorder (ADHD) in children.

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Elizabeth Lin on Diabetes and Depression

Dr. Elizabeth Lin discusses an NIMH-funded study linking diabetes and depression. She looks at the challenges patients face… as well as action steps for greater well-being.

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Special Report – Health Concerns in Haiti: Infectious Disease and Mental Health Perspective

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Symptoms and Treatment of Depression

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People with depression discuss how they got help.

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