Science News from 2009

Runaway Vigilance Hormone Linked to Panic Attacks

Science Update • December 28, 2009

A study has linked panic disorder to a wayward hormone in a brain circuit that regulates vigilance. While too little of the hormone, called orexin, is known to underlie narcolepsy, the new study suggests that too much of it may lead to panic attacks that afflict 6 million American adults.

National Survey Tracks Rates of Common Mental Disorders Among American Youth

Press Release • December 14, 2009

Only about half of American children and teenagers who have certain mental disorders receive professional services, according to a nationally representative survey funded in part by the National Institute of Mental Health (NIMH). The survey also provides a comprehensive look at the prevalence of common mental disorders.

Non-Invasive Technique Blocks a Conditioned Fear in Humans

Press Release • December 09, 2009

Scientists have for the first time selectively blocked a conditioned fear memory in humans with a behavioral manipulation. Participants remained free of the fear memory for at least a year. The research builds on emerging evidence from animal studies that reactivating an emotional memory opens a 6-hour window of opportunity in which a training procedure can alter it.

Behavioral Training Improves Connectivity and Function in the Brain

Press Release • December 09, 2009

Children with poor reading skills who underwent an intensive, six-month training program to improve their reading ability showed increased connectivity in a particular brain region, in addition to making significant gains in reading, according to a study funded in part by the National Institute of Mental Health (NIMH). The study was published in the Dec. 10, 2009, issue of Neuron.

Substance Use Associated with Low Response to Depression Treatment Among Teens

Science Update • December 09, 2009

Depressed teens who report low levels of impairment related to drug or alcohol use tended to respond better to depression treatment than depressed teens with higher levels substance-related impairment, according to an analysis of data from the NIMH-funded Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) study. However, it is unclear whether less substance-related impairment allowed for better response to depression treatment, or if better treatment response led to less substance-related impairment. The study was published in the December 2009 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.

Major Databases Link Up to Advance Autism Research

Press Release • December 08, 2009

Researchers studying autism spectrum disorders (ASD) will soon have access to a vast range of data and research tools through the NIH National Database for Autism Research (NDAR).

Autism Intervention for Toddlers Improves Developmental Outcomes

Science Update • December 08, 2009

Children with autism who receive a high intensity developmental behavioral intervention starting by age 18–30 months show major improvements in IQ, language, adaptive behavior, and severity of their diagnosis, according to an NIMH-funded study.

Silenced Gene for Social Behavior Found in Autism

Science Update • December 03, 2009

For the first time, inherited disruption of gene expression in a brain system for social behavior has been implicated in autism. NIMH grantee Margaret Pericak-Vance, Ph.D., at the University of Miami and Simon Gregory, Ph.D., at Duke University, and a multinational team of researchers found evidence for such epigenetic effects on the gene for the oxytocin receptor -- part of a brain system that mediates social behaviors disturbed in autism. The findings suggest a potential genetic biomarker for the disorder.

Symptoms in Mice Lacking a Single Receptor Type Mimic the Development of Schizophrenia

Science Update • December 03, 2009

Deleting one type of neurotransmitter receptor in a specific population of brain cells can induce schizophrenia-like behavior in mice, but only when the receptor is deleted early in development, according to a study by NIMH intramural scientists. The work provides strong support for previous observations implicating these receptors in psychosis; further, the mice provide a model of how psychotic symptoms can arise from a disruption in neuronal development, consistent with observations of how schizophrenia emerges in humans.

One Subtype of HIV Increases Risk of HIV-associated Dementia

Science Update • December 03, 2009

In a study of HIV-related cognitive impairment in Uganda, people with HIV subtype D were more likely than those with the other subtypes to have HIV-associated dementia (HAD), according to NIMH-funded researchers. This study, published in the September 1, 2009, issue of Clinical Infectious Diseases, is the first to show that HIV subtype may affect a person’s risk for developing HAD.

Parent Training Complements Medication for Treating Behavioral Problems in Children with Pervasive Developmental Disorders

Press Release • November 20, 2009

Treatment that includes medication plus a structured training program for parents reduces serious behavioral problems in children with autism and related conditions, according to a study funded by the National Institute of Mental Health (NIMH). The study, which was part of the NIMH Research Units on Pediatric Psychopharmacology (RUPP) Autism Network, was published in the December 2009 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.

Long-term Depression Treatment Leads to Sustained Recovery for Most Teens

Science Update • November 18, 2009

Long-term treatment of adolescents with major depression is associated with continuous and persistent improvement of depression symptoms in most cases, according to the most recent analysis of follow-up data from the NIMH-funded Treatment of Adolescents with Depression Study (TADS). The report, along with a commentary compiling the take-home messages of the study, was published in the October 2009 issue of the American Journal of Psychiatry.

NIH Encourages Depressed Moms to Seek Treatment for Themselves

Science Update • November 13, 2009

Numerous studies have suggested that depression runs in families. Children of depressed parents are 2–3 times as likely to develop depression as compared to children who do not have a family history of the disorder. Other studies have shown that remission of depression in mothers is associated with improvements in psychiatric symptoms in their children. Despite all signs encouraging mothers to prioritize their own mental health, many suffer from untreated depression while managing treatment for their children’s emotional or behavioral problems.

Recovery Act Grant Aims to Teach Kids with Autism How to Better Express Themselves

Science Update • November 12, 2009

Most children with autism spectrum disorders (ASD) seem to have trouble engaging in everyday social interactions. They may seem to have no reaction to other people or may respond atypically when others show anger or affection. Their own facial expressions, tone of voice, and body language may not match what they are saying, making it difficult for others to respond appropriately. Such barriers to communication can isolate children with ASD from their peers.

NIMH Seeks More BRAINS

Press Release • November 10, 2009

The National Institute of Mental Health is seeking more BRAINS for 2010 by offering a second round of Biobehavioral Research Awards for Innovative New Scientists (BRAINS). The program calls for innovative and groundbreaking research projects from early stage investigators to explore the complex mechanisms underlying mental disorders or novel treatments and prevention strategies. Proposed projects should address research priorities and gap areas identified in the NIMH Strategic Plan. Researchers interested in applying for these awards must submit their applications by Dec. 9, 2009.

NIH Awards More than 50 Grants to Boost Search for Causes, Improve Treatments for Autism

Press Release • November 04, 2009

The National Institutes of Health (NIH) awarded more than 50 autism research grants, totaling more than $65 million, which will be supported with American Recovery and Reinvestment Act (Recovery Act) funds. These grants are the result of the largest funding opportunity for research on autism spectrum disorders (ASD) to date, announced in March 2009.

Kids’ Brain Development Charted as They Grow Up

Science Update • November 03, 2009

A landmark, multisite NIH-funded neuroimaging study of brain development in healthy, normally-developing children has posted its third release of data. This is the first release from the magnetic resonance imaging (MRI) study to include data from very young children – birth to 4 years old – and snapshots of brain chemistry at key developmental milestones. The data is accessible to qualified researchers via the NIH Pediatric MRI Data Repository website.

Clinical Tests Begin on Medication to Correct Fragile X Defect

Press Release • November 02, 2009

NIH-supported scientists at Seaside Therapeutics in Cambridge, Mass., are beginning a clinical trial of a potential medication designed to correct a central neurochemical defect underlying Fragile X syndrome, the most common inherited cause of intellectual disability. There has to date been no medication that could alter the disorder’s neurologic abnormalities. The study will evaluate safety, tolerability, and optimal dosage in healthy volunteers.

Significant Weight Gain, Metabolic Changes Associated with Antipsychotic Use in Children

Science Update • October 27, 2009

Many children and adolescents who receive antipsychotic medications gain a significant amount of weight and experience metabolic changes, according to NIMH-funded research published October 28, 2009, in the Journal of the American Medical Association.

Telephone-based Depression Treatment Program Effective While Cost Efficient

Science Update • October 16, 2009

Patients who receive structured, telephone-based support to manage their depression gain significant benefits with only moderate increases in health care costs compared to those who receive usual care, according to an NIMH-funded analysis published in the October 2009 issue of the Archives of General Psychiatry.

History of Childhood Maltreatment Linked to Higher Rates of Unemployment, Poverty

Science Update • October 15, 2009

The long-term impacts of childhood maltreatment include higher rates of unemployment, poverty, and use of social services in adulthood, according to a new study by David Zielinski, Ph.D., of the NIMH Office of Science Policy, Planning, and Communications. The related losses in productivity and tax revenues, increased spending on social services, and potential transmission of abusive behaviors from one generation to the next, suggest major costs to society as well. The results were published online ahead of print on October 8, 2009, in the journal Child Abuse and Neglect.

High-Tech Robots’ Efforts Bear Fruit Thanks to NIH Roadmap

Science Update • October 08, 2009

Researchers recently announced discovery of a new class of molecules that holds promise for blocking the clumps of protein that clog the brain in Alzheimer’s disease. The new findings are the latest made possible by the NIH Roadmap Molecular Libraries initiative, which employs high-tech robots and molecular genetics to speedily screen molecules for their biological effects. The discovery required testing nearly 300,000 compounds – a task thought insurmountable just a decade ago.

Atlas Will Reveal When and Where Genes Turn On in the Brain

Science Update • October 06, 2009

When and where in the brain a gene turns on holds clues to its possible role in disease. For example, a recent study found that forms of a gene associated with schizophrenia are over-expressed in the fetal brain, adding to evidence implicating this critical developmental period.

PTSD Treatment Efforts for Returning War Veterans to be Evaluated

Science Update • September 30, 2009

Joan Cook, Ph.D., of Yale University and colleagues have been awarded funds from the American Recovery and Reinvestment Act of 2009 to evaluate the implementation of two evidence-based psychotherapies for treating post traumatic stress disorder (PTSD) among veterans. The grant addresses the NIH Challenge Grant topic “Strategies to Support Uptake of Interventions within Clinical Community and Settings.”

New Approach to Reducing Suicide Attempts Among Depressed Teens

Science Update • September 29, 2009

A novel treatment approach that includes medication plus a newly developed type of psychotherapy that targets suicidal thinking and behavior shows promise in treating depressed adolescents who had recently attempted suicide, according to a treatment development and pilot study funded by the National Institute of Mental Health (NIMH). The study, described in three articles, was published in the October 2009 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.

NIH Funds Four Centers of Excellence in Genomic Science

Press Release • September 28, 2009

The National Human Genome Research Institute (NHGRI) and National Institute of Mental Health (NIMH), both part of the National Institutes of Health, today announced grants expected to total approximately $45 million to establish new Centers of Excellence in Genomic Science at the Medical College of Wisconsin and University of North Carolina, Chapel Hill as well as to continue support of existing centers at Johns Hopkins University and the University of Southern California.

First Direct Evidence: Instability is the Normal State of the Brain’s Cortex

Science Update • September 21, 2009

Even when we’re not doing much of anything, our brain’s cortex, or outer mantle, is bustling with activity. In fact, scientists for the first time have detected “avalanches” of cortex activity in awake monkeys at rest.

Schizophrenia Linked to Over-expression of Gene in Fetal Brain

Science Update • August 28, 2009

A gene called DISC1, (for “disrupted in schizophrenia”) has been a leading contender among possible genetic causes since it was implicated in schizophrenia in a large Scottish clan two decades ago. The DISC1 gene codes for a protein important for brain development, as well as for mood and memory – functions that are disturbed in schizophrenia. However, until now there have been few clues as to how DISC1 might increase risk for the chronic mental disorder.

Focusing Efforts on Early-Stage HIV Interventions May Help Prevent Spread of Disease

Science Update • August 24, 2009

Screening and early intervention with people in the earliest stages of HIV infection may reduce the spread of the disease, according to NIMH-funded researchers. A series of five papers from a small, multisite study were published online ahead of print in June 2009 in the journal AIDS and Behavior.

Web-based Programs Encourage Safer Sex Behaviors among Men at Risk for HIV/AIDS

Science Update • August 11, 2009

A single-session, online, multimedia intervention effectively reduced risky sexual behaviors among young men who have sex with men, a group at high risk for HIV/AIDS and other sexually transmitted infections. Such low-cost programs may help reverse the steady rise in HIV diagnoses among this population.