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Science News About Alzheimer’s Disease

Suppressing Protein May Stem Alzheimer’s Disease Process

Press Release

CD33 activity and beta-amyloid

Scientists funded by the National Institutes of Health have discovered a potential strategy for developing treatments to stem the disease process in Alzheimer’s disease, by blocking activity of a little-known regulator protein called CD33.

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Mental Decline Thwarted in Aging Rats

Press Release

P7C3 compound chemical structure

Scientists have discovered a compound that restores the capacity to form new memories in aging rats, likely by improving the survival of newborn neurons in the brain's memory hub. The research, funded in part by the National Institutes of Health, has turned up clues to a neuroprotective mechanism that could lead to a treatment for Alzheimer's disease.

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Use of Antipsychotics in Alzheimer’s Patients May Lead to Detrimental Metabolic Changes

Science Update

Woman looking out a window (photograph).

Atypical antipsychotic medications are associated with weight gain and other metabolic changes among patients with Alzheimer’s disease, according to a recent analysis of data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness—Alzheimer’s Disease (CATIE-AD) study. The study was published online ahead of print April 15, 2009, in the American Journal of Psychiatry.

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Antipsychotic Medications May Ease Some Alzheimer’s Symptoms, Not Others

Science Update

Antipsychotic medications may lessen symptoms like hostility and aggression in patients with Alzheimer’s disease, but do not appear to lessen other symptoms or improve quality of life, according to a recent analysis of data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness Alzheimer’s Disease (CATIE-AD) study.

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Cortex Area Thinner in Youth with Alzheimer’s-Related Gene

Press Release

A part of the brain first affected by Alzheimer’s disease is thinner in youth with a risk gene for the disorder, a brain imaging study by researchers at the National Institute of Mental Health (NIMH), one of the National Institutes of Health (NIH), has found.

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Antipsychotic Medications Used to Treat Alzheimer’s Patients Found Lacking

Press Release

Commonly prescribed antipsychotic medications used to treat Alzheimer’s patients with delusions, aggression, hallucinations, and other similar symptoms can benefit some patients, but they appear to be no more effective than a placebo when adverse side effects are considered, according to the first phase of a large-scale clinical trial funded by NIMH.

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Lithium Shows Promise Against Alzheimer’s in Mouse Model

Press Release

An enzyme crucial to formation of Alzheimer’s plaques and tangles may hold promise as a target for future medications, suggest studies in mice and cells.

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Study Boosts Confidence in Potential Screening Tool for Alzheimer's Disease

Press Release

A major study has confirmed the value of potential markers for identifying people with Alzheimer's disease.

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