Science News about Clinical Research and Trials
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- Clinical Tests Begin on Medication to Correct Fragile X Defect
- Press Release November 02, 2009
NIH-supported scientists at Seaside Therapeutics in Cambridge, Mass., are beginning a clinical trial of a potential medication designed to correct a central neurochemical defect underlying Fragile X syndrome, the most common inherited cause of intellectual disability. There has to date been no medication that could alter the disorder’s neurologic abnormalities. The study will evaluate safety, tolerability, and optimal dosage in healthy volunteers.
- Telephone-based Depression Treatment Program Effective While Cost Efficient
- Science Update October 16, 2009
Patients who receive structured, telephone-based support to manage their depression gain significant benefits with only moderate increases in health care costs compared to those who receive usual care, according to an NIMH-funded analysis published in the October 2009 issue of the Archives of General Psychiatry.
- New Approach to Reducing Suicide Attempts Among Depressed Teens
- Science Update September 29, 2009
A novel treatment approach that includes medication plus a newly developed type of psychotherapy that targets suicidal thinking and behavior shows promise in treating depressed adolescents who had recently attempted suicide, according to a treatment development and pilot study funded by the National Institute of Mental Health (NIMH). The study, described in three articles, was published in the October 2009 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.
- Combination Treatment for Psychotic Depression Holds Promise
- Science Update August 07, 2009
A combination of an atypical antipsychotic medication and an antidepressant known as a selective serotonin reuptake inhibitor (SSRI) may be more effective in treating psychotic depression than an atypical antipsychotic alone, according to results from an NIMH-funded clinical study.
- Searching for Risk Factors of Suicidal Events During Antidepressant Treatment
- Science Update May 29, 2009
A new set of analyses of the NIMH-funded Treatment for Adolescents with Depression Study (TADS) were conducted to better understand what may predict the development of suicidal events during treatment. The analyses, which were published in the May 2009 issue of the Journal of Clinical Psychiatry, showed that youths with suicidal thoughts and more severe depression prior to treatment were at higher risk for suicidal events while undergoing treatment.
- HIV Prevention Program Gets a Boost From NIMH Recovery Act Funds
- Press Release May 26, 2009
Developing interventions to reduce the spread of HIV and other sexually transmitted infections among heterosexual men, couples and ethnically diverse populations continues to be complex and challenging. To help address this issue, NIMH awarded a two-year grant to David Pérez-Jiménez, Ph.D., at the University of Puerto Rico, to support the adaptation and assessment of an HIV and other sexually transmitted infection intervention designed for young, heterosexual Latino couples. This grant will use funds allocated to NIMH through the American Recovery and Reinvestment Act to promote economic recovery and spur advances in science and health.
- Short-term Intensive Treatment Not Likely to Improve Long-term Outcomes for Children with ADHD
- Science Update March 26, 2009
Short-term Intensive Treatment Not Likely to Improve Long-term Outcomes for Children with ADHD
- Brain Awareness Week Teaches Kids How Their Brains Work
- Press Release March 17, 2009
The 10th annual Brain Awareness Week (BAW), a science and health education fair held in various locations across the United States, teaches fifth through eighth grade students about the brain. In Washington, D.C., it will take place March 16-20, 2009, at the National Museum of Health and Medicine at Walter Reed Army Medical Center. Several institutes from the National Institutes of Health will provide interactive exhibits and lectures focusing on brain health and neuroscience on March 18th and 19th.
- Adolescents with Depression Not Harmed in Studies Using Placebo
- Science Update January 15, 2009
Teens with depression who initially are randomly assigned to placebo treatment (inactive pill) during a trial are no more likely to experience harm or have a diminished response to subsequent active treatments than teens who are initially randomized to active treatment, according to an analysis of data from the NIMH-funded Treatment for Adolescents with Depression Study (TADS).
- Intervention Helps Reduce Risky Sexual Behavior Among Homeless HIV-positive Adults
- Science Update December 16, 2008
An NIMH-funded program already shown to reduce risky sexual and substance abuse behavior among HIV-infected adults also appears to be effective in improving the lives of HIV-infected homeless or near-homeless adults, according to a new report.
- Depression Relapse Less Likely Among Teens Who Receive CBT After Medication Therapy
- Science Update December 05, 2008
Adolescents with major depression who received cognitive behavioral therapy (CBT) after responding to an antidepressant were less likely to experience a relapse or recurrence of symptoms compared to teens who did not receive CBT, according to a small, NIMH-funded pilot study published in the December 2008 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.
- NIMH, U.S. Army Sign MOA to Conduct Groundbreaking Suicide Research
- Science Update November 12, 2008
NIMH and the U.S. Army have entered into a memorandum of agreement (MOA) to conduct research that will help the Army reduce the rate of suicides.
- Study Identifies Three Effective Treatments for Childhood Anxiety Disorders
- Press Release October 30, 2008
Treatment that combines a certain type of psychotherapy with an antidepressant medication is most likely to help children with anxiety disorders, but each of the treatments alone is also effective.
- Certain Antipsychotic Medications May Increase Risk for Heart Disease
- Science Update October 16, 2008
Certain atypical antipsychotic medications may raise the risk for heart disease in people with schizophrenia, according to an analysis of data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study.
- New Study to Evaluate Ways to Control Metabolic Side Effects of Antipsychotics
- Science Update October 01, 2008
A new NIMH-funded grant will examine ways to control the metabolic side effects associated with the use of the newer atypical antipsychotic medications in children with schizophrenia or bipolar disorder.
- Newer Antipsychotics No Better Than Older Drug in Treating Child and Adolescent Schizophrenia
- Press Release September 15, 2008
Two newer atypical antipsychotic medications were no more effective than an older conventional antipsychotic in treating child and adolescent schizophrenia and may lead to more metabolic side effects, according to a new study funded by the National Institutes of Health’s National Institute of Mental Health (NIMH).
- Family-Focused Therapy Effective in Treating Depressive Episodes of Bipolar Youth
- Science Update September 01, 2008
Adolescents with bipolar disorder who received a nine-month course of family-focused therapy (FFT) recovered more quickly from depressive episodes and stayed free of depression for longer periods than a control group, according to an NIMH-funded study published September 2008 in the Archives of General Psychiatry.
- New Research to Refine Approaches in Psychotherapy
- Science Update August 29, 2008
Psychotherapy is a crucial part of treatment for many mental disorders, but it can be difficult to identify the right approach for an individual.
- Antipsychotic Does Not Harm—and May Improve—Cognitive Skills in Children with Autism
- Science Update August 27, 2008
The atypical antipsychotic medication risperidone (Risperdal) does not negatively affect cognitive skills of children with autism, and may lead to improvements, according to an NIMH-funded study published recently in the Journal of Child and Adolescent Psychopharmacology.
- Health Risks Associated with Certain Antipsychotics Warrant Extra Monitoring
- Science Update July 24, 2008
Some atypical antipsychotics may be more likely than others to cause metabolic and cardiovascular side effects, according to recent analyses using data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE).
- Age-related Decline of ADHD Symptoms Disrupted by Middle School
- Science Update July 21, 2008
Although symptoms of attention deficit/hyperactivity (ADHD) can last into adulthood, typically they decline as a child gets older.
- Newer Antipsychotics No Better Than Older Medications in Reducing Schizophrenia-related Violence
- Science Update July 11, 2008
Antipsychotic medications can reduce the risk of violence among people with schizophrenia, but the newer atypical antipsychotics are no more effective in doing so than older medications, according to a recent analysis of data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE).
- Antipsychotic Medications May Ease Some Alzheimer’s Symptoms, Not Others
- Science Update June 23, 2008
Antipsychotic medications may lessen symptoms like hostility and aggression in patients with Alzheimer’s disease, but do not appear to lessen other symptoms or improve quality of life, according to a recent analysis of data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness Alzheimer’s Disease (CATIE-AD) study.
- New Grant Aims to Overcome Obesity in People with Serious Mental Illness
- Science Update June 20, 2008
A new grant funded by NIMH will test the effectiveness of a promising intervention designed to help people with serious mental illness (SMI) who are overweight or obese lose weight and keep it off.
- HIV-positive Survivors of Sexual Abuse Who Receive Coping Intervention Less Likely to Engage in Unprotected Sex
- Science Update May 23, 2008
HIV-positive people who have experienced childhood sexual abuse are less likely to engage in risky sexual behavior if they receive a group intervention designed to help them cope with their traumatic history, according to an NIMH-funded study published April 1, 2008, in the Journal of Acquired Immune Deficiency Syndrome.
- Medication-only Therapy and Combination Therapy Both Cost Effective for Treating Teens with Depression
- Science Update May 12, 2008
Treating depressed teenagers with either the antidepressant fluoxetine (Prozac) or a combination of fluoxetine and psychotherapy can be cost effective, according to a recent economic analysis of the NIMH-funded Treatment for Adolescents with Depression Study (TADS). The study was published online ahead of print April 15, 2008, in the American Journal of Psychiatry.
- Study launched to test possible preventive treatment for schizophrenia in high risk youth
- Science Update May 01, 2008
NIMH has recently awarded a grant to study whether an intensive computerized training program can help prevent those at high risk of developing schizophrenia from having a first psychotic episode and improve adaptive functioning. The program is based on principles of brain development and resilience and an understanding of the processes that go awry in schizophrenia.
- Maintenance Treatment Crucial for Teens’ Recovery from Depression
- Science Update April 08, 2008
Long-term maintenance treatment is likely to sustain improvement and prevent recurrence among adolescents with major depression, according to an NIMH-funded study published in the April 2008 issue of the Archives of General Psychiatry.
- Group Therapy Program Offers Meaningful Gains for People with Borderline Personality Disorder
- Science Update February 26, 2008
A 20-week group therapy program focusing on cognitive behavioral and skills training, when used in conjunction with usual care, helped reduce symptoms of borderline personality disorder and improve overall functioning, reported NIMH-funded researchers.
- Teens with Treatment-resistant Depression More Likely to Get Better with Switch to Combination Therapy
- Press Release February 26, 2008
Teens with difficult-to-treat depression who do not respond to a first antidepressant medication are more likely to get well if they switch to another antidepressant medication and add psychotherapy rather than just switching to another antidepressant, according to a large, multi-site trial funded by the National Institutes of Health’s National Institute of Mental Health (NIMH). The results of the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial were published February 27, 2008, in the Journal of the American Medical Association (JAMA).
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- Out of Sync With the World: Body Clocks of Depressed People Are Altered at Cell LevelExternal Link: Please review our disclaimer.
- Nerve Stimulation for Severe Depression Changes Brain FunctionExternal Link: Please review our disclaimer.
- Nearly 20 Percent of Suicidal Youths Have Guns in Their HomeExternal Link: Please review our disclaimer.