The Maturation of Functional Brain Networks: Insight into the Origins and Course of Mental Disorders
January 27, 2011 – January 28, 2011
Day 1: January 27
Welcome, Introductions, and Workshop Objectives
Philip Wang: Deputy Director, NIMH
Session 1: New Approaches to Study Neural Network Connectivity
Review technical and analytical innovations in the measurement of network dynamics, including advances in electrophysiology, and functional, structural and optical imaging. Discuss the evolving definition of functional networks, and the methodologies used to define and analyze them. Examine issues of data interpretation, and temporal and spatial scaling.
Session 1: Continued
Session 1: Discussion
Session 2: Structure-Function Relationships over the Course of Development
Examine the dynamic relationships between functional networks and neuroanatomy through development. Discuss challenges in scaling anatomical metrics from an adult brain to a developing brain. Evaluate boundaries in interpreting data from non-invasive methods to draw conclusions regarding connectivity. Identify opportunities to link data on known neural circuitry from tract-tracing studies in animals to inform on human data using non-invasive methods. Discuss strategies to reveal the neurobiological basis of signals from imaging studies.
Session 2: Discussion
Session 3: Maturation of Neural Networks in Typical and Atypical Development
Review our current knowledge of how neural network trajectories in mental disorders deviate from typical development. Evaluate how aberrant network dynamics relate to disorder symptomatology and/or domains of function. Discuss whether changes in spatial and temporal network dynamics can serve as biomarkers, and what aspects of brain development or the disease process these biomarkers could potentially identify.
Session 3: Discussion
|4:45 p.m.||Summary/Charge for Day 2|
Day 2: January 28
Day 1 Recap
Session 4: Opportunities and Challenges in Neural Network Studies Using a Prospective, Longitudinal Design
Discuss the scientific advantages, caveats, and practical challenges in using such a design to study pediatric clinical populations.
General Discussion: Recommendations and Next Steps