In May, the NIMH Center for Mental Health Research on AIDS convened this two-day meeting in Bethesda, Maryland. The workshop had two broad objectives. The first objective was to review state-of-the-art NeuroAIDS research and treatment strategies. The emphasis was on identifying the most promising strategies for preclinical drug discovery, translational research, and clinical trials for the development of CNS-targeted therapeutics for HIV-associated neurological and neuropsychiatric disorders. The second objective was to discuss and determine which resources and mechanisms the NIH could provide to the scientific community to assist with such therapeutic interventions. The multidisciplinary group of participants presented and discussed the current challenges and limitations in NeuroAIDS therapeutics. The meeting also outlined the most promising approaches for the development of novel advances and provided suggestions regarding the future directions of research to eliminate/eradicate HIV brain reservoirs. In addition, the workshop addressed issues related to public-private partnerships and their role in drug discovery and development. For more information, please contact Dr. Kathy Kopnisky.