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Meeting Agenda
Bethesda, Maryland

Day 1: Tuesday April 24, 2012

8:00 AM – Breakfast

8:30 AM – Introduction

  • Thomas R. Insel, M.D. (NIMH)
    Welcome
  • David M. Panchision, Ph.D. (NIMH)
    Cell Reprogramming Overview and Meeting Goals
  • Jeffrey S. Nye, M.D., Ph.D. (Janssen / Johnson & Johnson)
    Promise and Perils of Reprogrammed Cells in Neuropsychiatric Disorders, Therapeutics Discovery

9:10 AM – Patient Selection Criteria: Clinical Phenotyping, Genetics
Chaired by Jeffrey S. Nye, M.D., Ph.D.

  • Russell L. Margolis, M.D. (Johns Hopkins University School of Medicine)
    Schizophrenia phenotype, genotype, and drug response: implications for human cell line studies
  • John Kelsoe, M.D. (University of California, San Diego)
    Genomics and pharmacogenomics of Bipolar Disorder: Strategies for cellular models
  • Joachim F. Hallmayer, M.D. (Stanford University)
    Genetics and clinical phenotyping of Autism Spectrum Disorders
  • Group-wide discussion including panel members:
    Andrew McIntosh, M.D. (University of Edinburgh)
    Flora M. Vaccarino, M.D. (Yale University)
    Judith L. Rapoport, M.D. (NIMH)
    Joachim F. Hallmayer, M.D.

10:30 AM – Break and Poster Viewing

10:50 AM – Reprogramming and Validation Strategies
Chaired by Jeffrey S. Nye, M.D., Ph.D.

  • Ludovic Vallier, Ph.D. (Wellcome Trust Sanger Institute; Cambridge University)
    Large scale derivation of human induced pluripotent stem cells: Old challenges and new opportunities
  • Paul J. Tesar, Ph.D. (Case Western Reserve University)
    Interrogating the transcriptome and chromatin landscape of distinct cell fates from pluripotent cells
  • Jeanne Loring, Ph.D. (Scripps Institute, La Jolla)
    Epigenetic stability in iPSCs, global phenotyping and the stem cell matrix database
  • Emile F. Nuwaysir, Ph.D. (Cellular Dynamics, Inc)
    Industrial-scale pipeline for high-throughput reprogramming and large volume production of differentiated cells
  • Nan Yang, Ph.D. (Stanford University)
    Making neurons from fibroblasts: Direct reprogramming to neural lineages
  • Group-wide discussion including panel members:
    Kevin Eggan, Ph.D. (Harvard University)
    Mike Sheldon, Ph.D. (Rutgers University)
    Mahendra Rao, Ph.D. (NIH Center for Regenerative Medicine)
    Nan Yang, Ph.D.

12:50 PM – Lunch and Main Poster Session (titles below)

  • Stewart A. Anderson, M.D. (Weill Cornell Medical College)
    Tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease
  • Ronald Hart, Ph.D. (Rutgers University)
    Neurogenesis using iPSC derived from cell repository specimens having specific risk-associated mutations
  • John Kelsoe, M.D.
    Pharmacogenomic Studies of Bipolar Disorder
  • Pascal Laeng, Ph.D. (Galenea Corp.)
    Optimization of neuronal cultures derived from hiPSCs for high throughput assays of synaptic function
  • Jeanne Loring, Ph.D.
    MicroRNA regulation of hESC proliferation
  • Andrew McIntosh, M.D.
    Modeling psychosis in families with rare private mutations
  • Jennifer Moore, Ph.D. (Rutgers University)
    Small-Scale, Footprint-Free Generation of Human iPSC from Cell Repository Specimens to Study Neuropsychiatric and Addiction Disorders
  • Kristopher Nazor, (Scripps Institute, La Jolla)
    DNA methylation in human PSCs

1:50 PM – Assays 1: Getting the “Right” Cell for the Job – Lessons from Neurological Disorders
Chaired by Stephen J. Haggarty, Ph.D. (Harvard, Broad Institute)

  • Kevin Eggan, Ph.D.
    iPSCs from Amyotophic Lateral Sclerosis and Syndrome Lesch-Nyhan
  • Kazuhiro Aiba, Ph.D. (Kyoto University)
    Site-directed integration of transgenes and human PSC-derived neurodegenerative disease models
  • Yasuyuki Asai, Ph.D. (ReproCELL, Inc.)
    Automated cellular assays for neuronal cell death
  • Lorenz P. Studer, M.D. (Memorial Sloan Kettering Cancer Center)
    From iPSC model to novel candidate therapeutic compounds – the case study of familial dysautonomia
  • Group-wide discussion including panel members:
    Paul J. Tesar, Ph.D.
    Russell L. Margolis, M.D.
    Evan Y. Snyder M.D., Ph.D. (Sanford Burnham Institute)
    Lorenz P. Studer, M.D.

3:10 PM – Break and Poster Viewing

3:30 PM – Assays 2: Cells to Systems – Developmental & Pathophysiological Relevance of Assays
Chaired by Stephen J. Haggarty, Ph.D.

  • Brian Tobe, M.D., Ph.D. (Sanford Burnham Institute)
    Merging proteomics with hiPSC-derived neurons for discovery of lithium targets in bipolar disorder
  • Stewart A. Anderson, M.D.
    Derivation and study of cerebral cortical GABAergic interneurons from human PSCs
  • Flora M. Vaccarino, M.D.
    Three dimensional in vitro differentiation assays derived from iPSCs
  • Guo-li Ming, Ph.D. (Johns Hopkins University School of Medicine)
    In vitro and transplantation studies of Schizophrenia patient-specific iPSCs
  • Group-wide discussion including panel members:
    Vikas Duvvuri, M.D., Ph.D. (University of California, San Diego)
    Jack Price, Ph.D. (King's College, London)
    Stewart A. Anderson, M.D.
    Guo-li Ming, Ph.D.

5:20 PM – Break and Poster Viewing

Events at Terrace Level

5:30 PM – Cash Bar Reception / Social

6:45 PM – Working Dinner for Invited Participants (Sponsored by One Mind for Research)
Topic: Steps toward the Formation of an International Collaboration

  • Brief Remarks by Jeffrey S. Nye, M.D., Ph.D.
  • Brief Remarks by Gen. Peter W. Chiarelli (One Mind for Research)
  • Discussion

Day 2: Wednesday April 25, 2012

8:00 AM – Breakfast

8:30 AM – Assays 3: Molecular Discovery, Target Identification, Screening
Chaired by Kalpana M. Merchant, Ph.D. (Eli Lilly and Company)

  • Herbert M. Lachman, M.D. (Albert Einstein College of Medicine)
    Transcriptome analysis of neurons derived from iPSCs
  • Sergiu Pasca, M.D. (Stanford University)
    Revealing cellular endophenotypes and potential drugs for Timothy syndrome using iPSCs
  • Pascal Laeng, Ph.D.
    Optimization of neuronal cultures derived from human iPSCs for high throughput assays of synaptic function
  • Stephen J. Haggarty, Ph.D.
    Targeting neuroplasticity using human iPSC-derived neurons
  • Group-wide discussion including panel members:
    Ludovic Vallier, Ph.D.
    Herbert M. Lachman, M.D.
    Stephen J. Haggarty, Ph.D.
    David Collier, Ph.D. (Eli Lilly & Company)
    William Z. Potter, M.D., Ph.D. (NIMH)

10:10 AM – Break and Poster Take-Down

10:30 AM – Coordinating Resources and Future Efforts
 Chaired by Kalpana M. Merchant, Ph.D.

  • Mike Sheldon, Ph.D. (Rutgers University)
    The NIMH Center for Collaborative Genetic Studies of Mental Disorders: Stem Cell Resource
  • Mahendra Rao, Ph.D.
    NIH Center for Regenerative Medicine
  • Yong Yao, Ph.D. (NIMH)
    NIH resources for target identification and screening
  • Group-wide discussion including panel members:
    Jay Tischfield, Ph.D. (Rutgers University)
    Jeanne Loring, Ph.D.
    John Kelsoe, M.D.
    Sarah J. Caddick, Ph.D. (Gatsby Charitable Foundation, UK)
    Linda S. Brady, Ph.D. (NIMH)

12:00 Noon – Meeting Adjourned