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Strategic Objective 3

Develop New and Better Interventions that Incorporate the Diverse Needs and Circumstances of People with Mental Illnesses

Purpose

NIMH invites grant applications from institutions and organizations that propose research to fulfill Objective 3 of the NIMH Strategic Plan: Develop New and Better Interventions that Incorporate the Diverse Needs and Circumstances of People with Mental Illness.

The Institute encourages applications that emphasize the development of innovative approaches to intervention through translation of new findings from basic science; through novel approaches to assessing outcomes in intervention studies; and through studies seeking to optimize interventions by tailoring treatments to key individual characteristics.

NIMH is shifting its priorities for funding intervention research in line with recommendations from a recent report of the National Advisory Mental Health Council, From Discovery to Cure: Accelerating the Development of New and Personalized Interventions for Mental Illnesses. This report stresses the need for innovation in phenotyping mental illnesses; pursuing new targets for intervention; and developing personalized approaches to treatment. NIMH seeks a new generation of clinical trials that will foster personalized mental health care and will give lower priority to large scale trials looking for incremental gains; expensive trials of on-patent medications without demonstrated superiority over off-patent medications; and trials adapting currently available treatments for new subpopulations.

Research priority areas are identified within the following four strategies:


 

These research topics are not intended to be exhaustive. Prior to submitting an application, investigators are encouraged to contact NIMH program staff to discuss proposed aims and relevance to these objectives. Please reference the relevant strategic objective and research priority in the project summary section of your application. Investigators are also encouraged to take advantage of existing NIMH and NIH resources where appropriate.