| CNS Radiotracers that have been advanced for use in Human Studies |
| Molecular Target |
11C-Labeled ligand |
18F-Labeled ligand |
123I-Labeled ligand |
| Neuroreceptor target |
| Metabotropic |
| Adenosine A1 |
[11C]MPDX |
[18F]CPFPX |
|
| Adenosine A2A |
[11C]SCH442416 |
[18F]MNI-444 |
[123I]MNI-420 |
| [11C]Preladenant |
|
|
| [11C]TMSX |
|
|
| CB1 |
[11C]MePPEP |
[18F]FEMMEP-d2 |
|
| [11C]OMAR |
[18F]MK-9470 |
|
| [11C]SD5024 |
|
|
| D1 |
[11C]NNC 112 |
[18F]MNI-968 ([18F]PF-8477) |
|
| [11C]SCH 23390 |
|
| D2/D3 |
[11C]Raclopride |
[18F]Fallypride |
[123I]IBZM |
| [11C]FLB 457 |
|
[123I]Epidepride |
| [11C]MNPA (agonist) |
|
[123I]IBF |
| [11C](+)PHNO (agonist) |
|
|
| [11C]NPA (agonist) |
|
|
| H1 |
[11C]Doxepin |
|
|
| H3 |
[11C]GSK189254 |
[18F]FMH3 |
|
| [11C]GR 103545 |
|
|
| 5-HT1A |
[carbonyl-11C]WAY |
[18F]FCWAY |
|
| [carbonyl-11C]DWAY |
[18F]MefWAY |
|
| [11C]CUMI-101 |
[18F]MPPF |
|
| 5-HT1B |
[11C]AZ10419369 |
|
|
| [11C]P943 |
|
|
| 5-HT2A |
[11C]MDL 100 907 |
[18F]Altanserin |
|
| [18F]Altanserin-d2 |
|
| [18F]Setoperone |
|
| 5-HT4 |
[11C]SB-207145 |
|
|
| 5-HT6 |
[11C]GSK-215083 |
|
|
| mGluR1 |
[11C]ITMM |
[18F]FIMX |
|
| mGluR5 |
[11C]ABP688 |
[18F]-FPEB |
|
| [18F]-PSS232 |
|
| NK1 |
|
[18F]SPA-RQ |
|
| [18F]MK-0999 ([18F]FE-SPA-RQ) |
|
| NOP |
[11C]NOP-1A |
|
|
| Opiate (DOR) |
[11C]Methylnaltrindole |
|
|
| Opiate (MOR) |
[11C]Diprenorphine |
[18F]Fluoroethyldiprenorphine |
|
| [11C]Carfentanil (agonist) |
|
|
| Opiate (KOR) |
[11C]GR103545 |
|
|
|
[11C]LY2795050 |
|
|
| Sigma |
[11C]SA4503 |
|
|
| Imidazoline Receptors (I2 binding site) |
[11C]BU99008 |
|
|
| Ionotropic |
| Bz(GABAA) |
[11C]Flumazenil |
[18F]Flumazenil |
|
| Bz (α5GABAA) |
[11C]Ro15 4513 |
|
| Nicotinic (α4β2) |
|
2-[18F]F-A-85380 (2-[18F]FA) |
[123I]51A |
| 6-[18F]FA |
| [18F]Nifene (agonist) |
| [18F]XTRA |
| [18F]GMOM |
| [18F]Flubatine |
| [18F]AZAN |
| Nicotinic (α7) |
[11C]CHIBA-1001 |
[18F]ASEM |
|
| NMDA |
|
[18F]GE-179 |
[123I]CNS1261 |
| P2X7 |
[11C]JNJ54173717 |
[18F]JNJ-64413739 |
|
| [11C]GSK-1482160 |
|
| Transporter target |
| DAT |
[11C]PE2I |
[18F]FP-CIT |
[123I]FP-CIT (DATSCAN) |
| [11C]Methylphenidate |
[18F]FE-PE2I |
[123I]CIT (Dopascan) |
|
[18F]FECNT |
[123I]Altropane |
|
|
[123I]PE2I |
| Glycine T1 |
[11C]CFpyPB |
[18F]CFPyPB |
|
| [11C]GSK 931145 |
|
| [11C]RO5013853 |
|
| NET |
[11C]MeNER-d2 |
[18F]FMeNER-d2 |
[123I]INER |
| SERT |
[11C]DASB |
[18F]ADAM |
[123I]CIT |
| [11C]MADAM |
[123I]mZIENT |
| [11C]AFM |
[123I]norβCIT |
| [11C]HOHMADAM |
[123I]βCIT |
|
[123I]ADAM |
| VMAT2 |
[11C]DTBZ |
[18F]florbenazine |
|
|
[11C]MTBZ |
[18F]AV-133 |
|
|
|
[18F]FP-DTBZ |
|
| VAChT |
|
[18F]FEOBV |
|
| Synaptic Proteins |
| SV2A |
[11C]UCB-J |
[18F]UCB-H |
|
| [11C]UCB-A |
|
| Channel like target |
| TSPO |
[11C](R)-PK 11195 |
[18F]FBR |
[123I]CLINDE |
| [11C]PBR28 |
[18F]FEPPA |
| [11C]DAA1106 |
[18F]PBR111 |
| [11C]DPA-713 |
|
| Enzyme target |
| AChE |
[11C]MP4A |
|
[123I]IBVM |
| Aromatase |
[11C]VOR |
|
|
| Cox-1 |
[11C]PS13 |
|
|
| FAAH |
[11C]CURB |
|
|
| [11C]MK3168 |
|
|
| HDAC 1-3 |
[11C]Martinostat |
|
|
| MAO-A |
[11C]Harmine |
|
|
|
[11C]Clorgyline |
|
|
|
[11C]Befloxatone |
|
|
| MAO-B |
[11C]Deprenyl-d2 |
|
|
| Mitochondrial Complex 1 |
|
[18F]BCPP-EF |
|
| PDE2A |
|
[18F]PF05270430 |
|
| PDE4 |
[11C](R)-Rolipram |
|
|
| PDE10A |
[11C]IMA107 |
[18F]MNI659 |
|
| [11C]MP-10 |
|
| [11C]Lu AE92686 |
|
| Aggregated protein target |
| β-Amyloid |
[11C]PIB |
[18F]Flutemetamol |
[123I]IMPY |
| [18F]Florbetapir([18F]AV-45) |
| [18F]AZD 4694 |
| [18F]FBM |
| [18F]FDDNP |
| [18F]W372 |
| [18F]Florbetaban |
| [18F]MK3328 |
| Tau/Synuclein |
[11C]PBB3 |
[18F]BF-227 |
|
| [11C]THK5351 |
[18F]Flortaucipir ([18F]AV-1451) |
|
[18F]THK5351 |
|
[18F]THK5317 |
|
[18F]THK5105 |
|
[18F]THK523 |
|
[18F]MK6240 |
|
[18F]RO948 |
