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CNS Radiotracer Table

CNS Radiotracers that have been advanced for use in Human Studies
Molecular Target 11C-Labeled ligand 18F-Labeled ligand 123I-Labeled ligand

Aggregated protein target

β-Amyloid

[11C]PIB

[18F]Flutemetamol

[18F]Florbetapir([18F]AV-45)

[18F]AZD 4694

[18F]FBM

[18F]FDDNP

[18F]-SMIBR-W372 ([F-18]-W372)

[18F]Florbetaban

[18F]MK3328

[123I]IMPY

Tau/Synuclein

 

 

[18F]BF-227

[18F]THK523

 

Channel target

TSPO

[11C](R)-PK 11195

[11C]PBR28

[11C]DAA1106

[11C]DPA-713

[18F]FBR

[18F]FEPPA

[18F]PBR111

[123I]CLINDE

 

Enzyme target

AChE

[11C]MP4A

 

[123I]IBVM

 

Aromatase

[11C]VOR

   
 

FAAH

[11C]CURB

   
 

MAO-A

[11C]Harmine

[11C]Clorgyline

[11C]Befloxatone

   
 

MAO-B

[11C]Deprenyl-d2

   
 

PDE4

[11C](R)-Rolipram

   
 

PDE10A

[11C]IMA107
[11C]MP-10
[11C]Lu AE92686

[18F]MNI659

 
 

Neuroreceptor target

Adenosine A1

 

[18F]CPFPX

 
 

Adenosine A2A

[11C]SCH442416

 

[123I]MNI420

 

Bz(GABAA)

[11C]Flumazenil

[18F]Flumazenil

 
 

Bz (α5GABAA)

[11C]Ro15 4513

   
 

CB1

[11C]MePPEP

[11C]OMAR

[11C]SD5024

[18F]FEMMEP-d2

[18F]MK-9470

 
 

D1

[11C]NNC 112

[11C]SCH 23390

   
 

D2/D3

[11C]Raclopride

[11C]FLB 457

[11C]MNPA (agonist)

[11C](+)PHNO (agonist)

[11C]NPA (agonist)

[18F]Fallypride

[123I]IBZM

[123I]Epidepride

 

H1

[11C]Doxepin

   
 

H3

[11C]GSK189254

[11C]GR 103545

[18F]FMH3

 
 

5-HT1A

[carbonyl-11C]WAY

[carbonyl-11C]DWAY

[11C]CUMI (agonist)

[18F]FCWAY

[18F]MefWAY

[18F]MPPF

 
 

5-HT1B

[11C]AZ10419369

[11C]P943

   
 

5-HT2A

[11C]MDL 1000907

[18F]Altanserin

[18F]Altanserin-d2

 

5-HT4

[11C]SB-207145

   
 

5-HT6

[11C]GSK-215083

   
 

mGluR1

 

[18F]FITM

 
 

mGluR5

[11C]SP 203

[11C]ABP688

[18F]SP 203

[18F]F-FPEB

 
 

Nicotinic (α4β2)

 

2-[18F]F-A-85380 (2-[18F]FA)

6-[18F]FA

[18F]Nifene (agonist)

[123I]5IA

 

Nicotinic (α7)

 

[11C]CHIBA-1001

 
 

NK1

 

[18F]SPA-RQ

[18F]MK-0999 ([18F]FE-SPA-RQ)

 

NOP

[11C]NOP-1A

   

Opiate (DOR)

[11C]Methylnaltrindole

   

Opiate (MOR)

[11C]Diprenorphine

[11C]Carfentanil (agonist)

[18F]Fluoroethyl-diprenorphine

 
 

Sigma

[11C]SA4503

   
 

Transporter target

DAT

[11C]PE2I

[11C]Methylphenidate

[18F]FP-CIT

[18F]FE-PE2I

[18F]FECNT

[123I]FP-CIT (DATSCAN)

[123I]CIT (Dopascan)

[123I]Altropane

[123I]PE2I

Glycine T1

[11C]CFpyPB

[11C]GSK 931145
[11C]RO5013853

[18F]CFPyPB

 
 

NET

[11C]MeNER-d2

[18F]FMeNER-d2

[123I]INER

 

SERT

[11C]DASB

[11C]MADAM

[11C]AFM

[11C]HOHMADAM

 

[123I]CIT

[123I]mZIENT

 

VMAT2

[11C]DTBZ
[11C]MTBZ

[18F]florbenazine
[18F]AV-133
[18F]FP-DTBZ)