CNS Radiotracer Table
| CNS Radiotracers that have been advanced for use in Human Studies | |||
|---|---|---|---|
| Molecular Target | 11C-Labeled ligand | 18F-Labeled ligand | 123I-Labeled ligand |
Aggregated protein target | |||
β-Amyloid | [11C]PIB | [18F]Flutemetamol [18F]Florbetapir([18F]AV-45) [18F]AZD 4694 [18F]FBM [18F]FDDNP [18F]-SMIBR-W372 ([F-18]-W372) [18F]Florbetaban [18F]MK3328 | [123I]IMPY |
Tau/Synuclein
|
| [18F]BF-227 [18F]THK523 | |
Channel target | |||
TSPO | [11C](R)-PK 11195 [11C]PBR28 [11C]DAA1106 [11C]DPA-713 | [18F]FBR [18F]FEPPA [18F]PBR111 | [123I]CLINDE |
Enzyme target | |||
AChE | [11C]MP4A | [123I]IBVM | |
Aromatase | [11C]VOR | ||
FAAH | [11C]CURB | ||
MAO-A | [11C]Harmine [11C]Clorgyline [11C]Befloxatone | ||
MAO-B | [11C]Deprenyl-d2 | ||
PDE4 | [11C](R)-Rolipram | ||
PDE10A | [11C]IMA107 | [18F]MNI659 | |
Neuroreceptor target | |||
Adenosine A1 | [18F]CPFPX | ||
Adenosine A2A | [11C]SCH442416 | [123I]MNI420 | |
Bz(GABAA) | [11C]Flumazenil | [18F]Flumazenil | |
Bz (α5GABAA) | [11C]Ro15 4513 | ||
CB1 | [11C]MePPEP [11C]OMAR [11C]SD5024 | [18F]FEMMEP-d2 [18F]MK-9470 | |
D1 | [11C]NNC 112 [11C]SCH 23390 | ||
D2/D3 | [11C]Raclopride [11C]FLB 457 [11C]MNPA (agonist) [11C](+)PHNO (agonist) [11C]NPA (agonist) | [18F]Fallypride | [123I]IBZM [123I]Epidepride |
H1 | [11C]Doxepin | ||
H3 | [11C]GSK189254 [11C]GR 103545 | [18F]FMH3 | |
5-HT1A | [carbonyl-11C]WAY [carbonyl-11C]DWAY [11C]CUMI (agonist) | [18F]FCWAY [18F]MefWAY [18F]MPPF | |
5-HT1B | [11C]AZ10419369 [11C]P943 | ||
5-HT2A | [11C]MDL 1000907 | [18F]Altanserin [18F]Altanserin-d2 | |
5-HT4 | [11C]SB-207145 | ||
5-HT6 | [11C]GSK-215083 | ||
mGluR1 | [18F]FITM | ||
mGluR5 | [11C]SP 203 [11C]ABP688 | [18F]SP 203 [18F]F-FPEB | |
Nicotinic (α4β2) | 2-[18F]F-A-85380 (2-[18F]FA) 6-[18F]FA [18F]Nifene (agonist) | [123I]5IA | |
Nicotinic (α7) | [11C]CHIBA-1001 | ||
NK1 | [18F]SPA-RQ [18F]MK-0999 ([18F]FE-SPA-RQ) | ||
NOP | [11C]NOP-1A | ||
Opiate (DOR) | [11C]Methylnaltrindole | ||
Opiate (MOR) | [11C]Diprenorphine [11C]Carfentanil (agonist) | [18F]Fluoroethyl-diprenorphine | |
Sigma | [11C]SA4503 | ||
Transporter target | |||
DAT | [11C]PE2I [11C]Methylphenidate | [18F]FP-CIT [18F]FE-PE2I [18F]FECNT | [123I]FP-CIT (DATSCAN) [123I]CIT (Dopascan) [123I]Altropane [123I]PE2I |
Glycine T1 | [11C]CFpyPB [11C]GSK 931145 | [18F]CFPyPB | |
NET | [11C]MeNER-d2 | [18F]FMeNER-d2 | [123I]INER |
SERT | [11C]DASB [11C]MADAM [11C]AFM [11C]HOHMADAM | [123I]CIT [123I]mZIENT | |
VMAT2 | [11C]DTBZ | [18F]florbenazine | |