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- Abnormal Surge in Brain Development Occurs in Teens and Young Adults with Schizophrenia
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July 8, 2008
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Science Update
Schizophrenia may occur, in part, because brain development goes awry during adolescence and young adulthood, when the brain is eliminating some connections between cells as a normal part of maturation, results of a study suggest. The new report appears online July 8, 2008 in Molecular Psychiatry.
- NIMH Schizophrenia Initiative Featured in Biological Psychiatry
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July 3, 2008
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Science Update
An NIMH initiative to fill the gap between advances in basic cognitive neuroscience and practical clinical applications for patients with schizophrenia is the topic of the July 1, 2008 issue of Biological Psychiatry. It contains eight articles on the Cognitive Neuroscience Approaches to the Treatment of Impaired Cognition in Schizophrenia (CNTRICS) initiative, including a commentary, and descriptions of meetings related to the effort.
- Mice Expressing Human Genes Bred to Help Unravel Mental Disorders
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June 26, 2008
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Science Update
New mouse strains engineered to express human genes related to mental disorders are being developed under a recently-launched grant program from NIMH's Division of Neuroscience and Basic Behavioral Science.
- Study launched to test possible preventive treatment for schizophrenia in high risk youth
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May 1, 2008
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Science Update
NIMH recently awarded a grant to study whether an intensive, computerized training program can help prevent youth at high risk for developing schizophrenia from having a first psychotic episode and improve adaptive functioning.
- Rates of Rare Mutations Soar Three to Four Times Higher in Schizophrenia
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March 27, 2008
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Press Release
People with schizophrenia have high rates of rare genetic deletions and duplications that likely disrupt the developing brain, according to studies funded in part by the National Institutes of Health.
- Scans Reveal Faulty Brain Wiring Caused by Missing Genes
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February 20, 2008
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Science Update
An NIMH study using an emerging imaging technology has discovered faulty wiring in the brains of people with Williams Syndrome, a rare genetic disorder that affects some aspects of thinking.
- Tomorrow’s Antidepressants: Skip the Serotonin Boost?
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February 14, 2008
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Science Update
Even when serotonin levels stayed low, scientists were able to correct abnormal, mental-illness-like behaviors in mice by blocking an enzyme called GSK3ß. The finding adds evidence that molecular targets other than serotonin may lead to better and faster medications for some mental illnesses.
- Scientists Can Predict Psychotic Illness in up to 80 Percent of High-Risk Youth
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January 7, 2008
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Press Release
Youth who are going to develop psychosis can be identified before their illness becomes full-blown 35 percent of the time if they meet widely accepted criteria for risk, but that figure rises to 65 to 80 percent if they have certain combinations of risk factors, the largest study of its kind has shown.
- Real-World Outcomes in Schizophrenia Are Focus of Two New NIMH Grants
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January 4, 2008
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Science Update
Two new NIMH grants are aimed at determining the most accurate methods of measuring how well community-dwelling people with schizophrenia are faring. Results of the project are meant to provide scientists who conduct future research on the effectiveness of treatments with tools that reflect the truest possible picture of daily-life outcomes.
- Ethnicity Predicts How Gene Variations Affect Response to Schizophrenia Medications
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January 2, 2008
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Science Update
Different variations in the same gene influence how well different ethnic groups, and people within the same ethnic group, respond to various antipsychotic medications, report NIMH-funded researchers. If confirmed, their findings could one day help clinicians predict which medication is most likely to help a patient, based on his or her genetic makeup.
