NIMH Pages about Bipolar Disorder

Overview of Bipolar Disorder…


Find current clinical trials on Bipolar Disorder…


Publications about Bipolar Disorder

Bipolar Disorder in Children and Adolescents (Fact Sheet)
Photo of an adolescent male. A fact sheet that describes the development in our understanding of how bipolar disorder affects children and adolescents and the direction of future research.
Bipolar Disorder
Bipolar A detailed booklet that describes bipolar disorder symptoms, causes, and treatments, with information on getting help and coping.
Bipolar Disorder in Children and Teens (Easy to Read)
Bipolar Disorder in Children and Teens An easy-to-read booklet on Bipolar Disorder in children and teens that explains what it is, when it starts and how to get help. En Español
Bipolar Disorder (Easy to Read)
Bipolar Disorder An easy-to-read booklet on Bipolar Disorder that explains what it is, when it starts and how to get help. En Español
Bipolar Disorder in Children and Teens: A Parent’s Guide
Bipolar This booklet is a guide for parents who think their child may have symptoms of bipolar disorder, or parents whose child has been diagnosed.

Science News about Bipolar Disorder

Gene Regulator in Brain’s Executive Hub Tracked Across Lifespan – NIH study
Press Release • February 02, 2012
PFC methylation For the first time, scientists have tracked the activity, across the lifespan, of an environmentally responsive regulatory mechanism that turns genes on and off in the brain’s executive hub. Among key findings of the study by National Institutes of Health scientists: genes implicated in schizophrenia and autism turn out to be members of a select club of genes in which regulatory activity peaks during an environmentally-sensitive critical period in development.
Atypical Antipsychotic More Effective than Older Drugs in Treating Childhood Mania, but Side Effects Can Be Serious
Science Update • January 11, 2012
young children feeling frustrated The antipsychotic medication risperidone is more effective for initial treatment of mania in children diagnosed with bipolar disorder compared to other mood stabilizing medications, but it carries the potential for serious metabolic side effects, according to an NIMH-funded study published online ahead of print January 2, 2012, in the Archives of General Psychiatry.
International Impact of Bipolar Disorder Highlights Need for Recognition and Better Treatment Availability
Science Update • March 07, 2011
Person sitting next to railroad tracks. The severity and impact of bipolar disorder and bipolar-like symptoms are similar across international boundaries, according to a study partially funded by NIMH.
Most Children with Rapidly Shifting Moods Don’t Have Bipolar Disorder
Science Update • November 30, 2010
child running in an open field Relatively few children with rapidly shifting moods and high energy have bipolar disorder, though such symptoms are commonly associated with the disorder. Instead, most of these children have other types of mental disorders, according to an NIMH-funded study published online ahead of print in the Journal of Clinical Psychiatry on October 5, 2010.
Rapid Antidepressant Works by Boosting Brain’s Connections 
Science Update • September 09, 2010
neuronal spines on ketamine-treated rat neurons An experimental drug that lifts depression in hours likely works by rapidly stimulating connections between brain cells, a study in rats has revealed. The drug, called ketamine, quickly generated such synapses in a brain circuit implicated in human depression by triggering a key enzyme.

Posts about Bipolar Disorder

NIMH’s Top 10 Research Advances of 2011

Psychiatric Genetics: More Pieces of the Puzzle

Results of the two largest studies of their kind, to date, have identified new common gene variants associated with schizophrenia and bipolar disorder. The results implicate specific pathways and hold promise for development of new treatments.

Skin cells to neurons: Disease-in-a-dish promises shortcut to discovery

An emerging research technology using Induced pluripotent stem cells holds promise as a window into the developing brain in mental illness.

Diagnosis: Pediatric Bipolar Disorder?

NIMH is working to better define the boundaries of pediatric bipolar disorder, discover its causes and develop more effective treatments for such mood related syndromes affecting youth. Cross-cutting comparisons of mania-related and other forms of irritability and functional brain imaging studies will help to disentangle these syndromes so that clinicians can provide children with the best care. Our goal is nothing less than pre-emtive interventions and cures.


Meeting Summaries about Bipolar Disorder

Bipolar Disorder in Children and Adolescents: New Data to Inform Classification
February 26, 2009 – February 27, 2009
Washington, DC

NIMH convened a working group of 24 invited experts to present and discuss data to resolve methodological discrepancies in the approaches used to diagnose bipolar disorder in children and adolescents.

Director’s Updates about Bipolar Disorder

NIMH Perspective on Diagnosing and Treating Bipolar Disorder in Children

September 03, 2007

A recently published research paper (September 2007, Archives of General Psychiatry) reported a 40-fold increase in the rate of diagnosing bipolar disorder in youth over the past decade.