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NIMH Pages About Clinical Research and Trials

Overview of Clinical Research and Trials…


Publications About Clinical Research and Trials

Neuroimaging and Mental Illness: A Window Into the Brain
Neuroimaging FAQ

Researchers use brain scans to study brain development in healthy people and people with illnesses. This publication answers frequently asked questions about what brain scans can and cannot do related to diagnosing mental illnesses.

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A Participant's Guide to Mental Health Clinical Research
Participants Guide

This brochure, prepared by the National Institute of Mental Health (NIMH), provides answers to common questions about volunteering for mental health clinical research.

En Español

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Science News About Clinical Research and Trials

NIH Directors Discuss Sequestration and Research on C-SPAN

Science Update

NIMH Director Tom Insel on C-SPAN

Despite facing lean financial times, NIH continues to generate the most bang for the buck regarding research. Tomorrow on C-SPAN Washington Journal, NIH Directors Drs. Collins, Insel, Fauci, Varmus, and Green will field questions from the public pertaining to sequestration and research as well as other topics.

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Community-based Treatments Offset Depression Disparities

Science Update

NIMH Researcher David Chambers, Ph.D.

Improving care for depression in low-income communities -- places where such help is frequently unavailable or hard to find -- provides greater benefits to those in need when community groups such as churches and even barber shops help lead the planning process, according to a new study.

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NIH Funds Industry Collaborations to Identify New Uses for Existing Compounds

Press Release

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NIH Funds Industry Collaborations to Identify New Uses for Existing Compounds

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Ketamine Cousin Rapidly Lifts Depression Without Side Effects

Science Update

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NMDA or glutamate receptor modulators as antidepressants have come of age. Human clinical studies demonstrated that ketamine can ward off depressive symptoms within 2 hours of administration and last for several days. Yet serious side effects are attached to this drug, including excessive sleepiness, hallucinations, and substance abuse behavior.

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NIH Study Shows People with Serious Mental Illnesses Can Lose Weight

Press Release

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Losing weight is challenging for everyone. It can be particularly difficult for someone with a serious mental illness. An NIMH-funded clinical study proves that a modified diet and exercise program can work for people with serious mental illnesses. Participants lost 7 pounds more than controls—and continued to lose weight.

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Posts About Clinical Research and Trials

Clues to Risk and Resilience: Army STARRS

By Thomas Insel on March 04, 2014

Dr. Insel talks about just published findings coming out of Army STARRS, a joint Army-NIMH effort to understand risk factors for suicide in the military.

A New Approach to Clinical Trials

By Thomas Insel on February 27, 2014

NIMH is changing how it will support clinical trials. Dr. Insel summarizes the changes and the reasons behind them.

Network Solutions

By Thomas Insel on February 05, 2013

Dr. Insel talks about how NIMH’s RAISE study is exploring an integrated, multi-component approach to health care for schizophrenia.

From Practice to Research

By Thomas Insel on November 15, 2012

Dr. Insel introduces an innovative approach that one group is taking to speed up the dissemination of research results into clinical practice.

A Promising Behavioral Treatment for Tourette Syndrome

By Thomas Insel on August 06, 2012

Dr. Insel describes a new behavioral treatment for a neurologically based disorder that has traditionally been difficult to treat. 


Meeting Summaries About Clinical Research and Trials

Alliance for Research Progress - July 12, 2013 Meeting

Bethesda, Maryland

Summary for the July 2013 meeting of the Alliance for Research Progress.

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Alliance for Research Progress - February 8, 2013 Meeting

Rockville, Maryland

Summary for the February 2013 meeting of the Alliance for Research Progress.

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Alliance for Research Progress - July 13, 2012 Meeting

Washington, DC

Summary for the July 2012 meeting of the Alliance for Research Progress.

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Using Stem Cells for Biological and Therapeutics Discovery in Mental Illness

Bethesda, Maryland

On April 24-25, 2012, scientists from academia, government and the private sector met to discuss advances and challenges in using patient-derived reprogrammed cells, such as induced pluripotent stem cells (iPSCs) and induced neuronal cells (iNCs), to identify molecular, cellular, and developmental alterations relevant to mental illnesses and possible utility in diagnostics and drug development.

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Alliance for Research Progress - February 10, 2012 Meeting

Rockville, Maryland

Summary for the February 2012 meeting of the Alliance for Research Progress.

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Director’s Updates About Clinical Research and Trials

NIMH Clinical Director Receives Prestigious Leadership Award

NIMH clinical director Dr. Maryland Pao has been named the 2012 recipient of the Simon Wile Leadership in Consultation Award by the American Academy of Child & Adolescent Psychiatry (AACAP).

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New and Existing Clinical Datasets Available to Qualified Researchers

Are you a researcher interested in studying datasets from NIMH clinical trials? If so, several datasets are available to those who are qualified.

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NIMH Perspective on Diagnosing and Treating Bipolar Disorder in Children

A recently published research paper (September 2007, Archives of General Psychiatry) reported a 40-fold increase in the rate of diagnosing bipolar disorder in youth over the past decade.

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NIMH Perspective on Antipsychotic Reimbursement: Using Results from the CATIE Cost Effectiveness Study

The recent publication (December 1, 2006, American Journal of Psychiatry) of the cost-effectiveness results from the National Institute of Mental Health (NIMH)-funded Clinical Antipsychotic Trials in Intervention Effectiveness (CATIE) has raised questions among advocates, families, and clinicians about reimbursement policies for antipsychotic medications.

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NIMH Perspective on Treating Alzheimer’s Patients with Antipsychotic Medications

The recent publication of phase 1 results from the NIMH-funded Clinical Antipsychotic Trials in Intervention Effectiveness for Alzheimer's disease (CATIE-AD) in the New England Journal of Medicine provides new information about the use of several "atypical" antipsychotic medications for the treatment of psychotic symptoms in patients with Alzheimer's disease.

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