NIMH Pages about Clinical Research and Trials

Overview of Clinical Research and Trials…


Publications about Clinical Research and Trials

Neuroimaging and Mental Illness: A Window Into the Brain
Neuroimaging FAQ Researchers use brain scans to study brain development in healthy people and people with illnesses. This publication answers frequently asked questions about what brain scans can and cannot do related to diagnosing mental illnesses.
A Participant's Guide to Mental Health Clinical Research
Participants Guide This brochure, prepared by the National Institute of Mental Health (NIMH), provides answers to common questions about volunteering for mental health clinical research.

Science News about Clinical Research and Trials

Computer-Based Treatment Eases Anxiety Symptoms in Children
Science Update • March 13, 2012
girl_uses_laptop.jpg Results from a small clinical trial suggest that it might be possible, using computer-based training, to help children with anxiety shift their attention away from threat.
NIH-funded study defines treatment window for HIV-positive children infected at birth
Press Release • March 07, 2012
mother holds baby boy HIV-positive children older than 1 year who were treated after showing moderate HIV-related symptoms did not experience greater cognitive or behavior problems compared to peers treated when signs of their infection were still mild, according to a study funded by the National Institutes of Health.
Atypical Antipsychotic More Effective than Older Drugs in Treating Childhood Mania, but Side Effects Can Be Serious
Science Update • January 11, 2012
young children feeling frustrated The antipsychotic medication risperidone is more effective for initial treatment of mania in children diagnosed with bipolar disorder compared to other mood stabilizing medications, but it carries the potential for serious metabolic side effects, according to an NIMH-funded study published online ahead of print January 2, 2012, in the Archives of General Psychiatry.
Suspect Gene Variants Boost PTSD Risk after Mass Shooting
Science Update • December 01, 2011
SERT and PTSD symptoms College students exposed to a mass shooting were 20-30 percent more likely to later develop post traumatic stress disorder (PTSD) symptoms if they harbored a risk version of a gene, NIMH-funded researchers have discovered.
Interventions Show Promise in Treating Depression Among Preschoolers
Science Update • November 17, 2011
young boy looks at adult A new psychosocial approach shows promise in helping preschoolers with symptoms of depression function better and learn to regulate their emotions, according to an NIMH-funded study published online ahead of print October 31, 2011, in the Journal of Child Psychology and Psychiatry.

Posts about Clinical Research and Trials

Citizen Science

By Thomas Insel on April 26, 2012

Presentations at a recent meeting in San Diego showed how new technologies are being used to change the culture of science, empowering patients, and fueling innovative research approaches.

The Future of Psychiatry (= Clinical Neuroscience)

By Thomas Insel on April 20, 2012

While fewer medical students are choosing psychiatry in the U.K., in the U.S. psychiatry is attracting increasing numbers of elite MD-PhD students who want to do research. These young scientists are committed to developing a new scientific basis for clinical care.

Treatment Development: Where do we go from here?

By Thomas Insel on January 05, 2012

Dr. Insel discusses opportunities for treatment development.

NIMH’s Top 10 Research Advances of 2011

By Thomas Insel on December 23, 2011

Dr. Insel shares NIMH’s Top 10 Research Advances for 2011.

Treatment Development: Where do we go from here?

By Thomas Insel on December 22, 2011

Dr. Insel discusses opportunities for treatment development.


Meeting Summaries about Clinical Research and Trials

Alliance for Research Progress — February 10, 2012 Meeting
February 10, 2012
Rockville, Maryland

Summary for the February 2012 meeting of the Alliance for Research Progress.
Alliance for Research Progress — July 29, 2011 Meeting
July 29, 2011
Bethesda, Maryland

Summary for the July 2011 meeting of the Alliance for Research Progress.
Alliance for Research Progress — February 18, 2011 Meeting
February 18, 2011
Bethesda, Maryland

Summary for the February 2011 meeting of the Alliance for Research Progress.
Integrating Neuroscience, Developmental Psychopathology, and Preventive Interventions: Critical Questions for the Next Generation of Transformative Research
June 01, 2010
Denver, Colorado

In conjunction with the 18th annual conference of the Society for Prevention Research, NIMH held a one-day, pre-conference workshop. The goal of the meeting was to identify strategies to advance prevention science research for mental disorders through the integration of basic science, neurodevelopment research, and intervention expertise.
Child and Adolescent Effectiveness Research in Clinical Practice and Community Settings: Needs, Challenges, and Opportunities
January 24, 2008 – January 25, 2008
Washington, D.C.

This workshop provided a forum for reviewing accomplishments and challenges in conducting effectiveness research in practice and other community settings and served as an opportunity for informally discussing promising approaches to further research. The focus of the meeting was on testing the effectiveness of treatment interventions for children and adolescents when delivered in clinical practice and other community settings, such as schools.

Director’s Updates about Clinical Research and Trials

NIMH Perspective on Diagnosing and Treating Bipolar Disorder in Children

September 03, 2007

A recently published research paper (September 2007, Archives of General Psychiatry) reported a 40-fold increase in the rate of diagnosing bipolar disorder in youth over the past decade.

NIMH Perspective on Antipsychotic Reimbursement: Using Results from the CATIE Cost Effectiveness Study

December 01, 2006

The recent publication (December 1, 2006, American Journal of Psychiatry) of the cost-effectiveness results from the National Institute of Mental Health (NIMH)-funded Clinical Antipsychotic Trials in Intervention Effectiveness (CATIE) has raised questions among advocates, families, and clinicians about reimbursement policies for antipsychotic medications.

NIMH Perspective on Treating Alzheimer’s Patients with Antipsychotic Medications

October 12, 2006

The recent publication of phase 1 results from the NIMH-funded Clinical Antipsychotic Trials in Intervention Effectiveness for Alzheimer's disease (CATIE-AD) in the New England Journal of Medicine provides new information about the use of several "atypical" antipsychotic medications for the treatment of psychotic symptoms in patients with Alzheimer's disease.