Job Vacancy Announcement – Staff Scientist 1

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
Division of Intramural Research Programs (IRP)
Section on Light and Circadian Rhythm (SLCR) 

Program Overview

The National Institute of Mental Health (NIMH), a major research component of the National Institutes of Health (NIH), and the Department of Health and Human Services (DHHS), is seeking exceptional candidates for a Staff Scientist 1 position in the Division of Intramural Research Programs (IRP), Section on Light and Circadian Rhythm (SLCR). At SLCR our research focuses on understanding the fundamental mechanisms by which intrinsically photosensitive retinal ganglion cells (ipRGCs) detect light and transmit this information to the brain, ultimately influencing physiology and behavior. Our work has identified ipRGCs as key players in regulating circadian rhythms, sleep and pupil constriction. These cells target various visual centers in the brain, including the circadian pacemaker and regions responsible for pupil constriction. Recent findings in our lab have revealed that ipRGCs are more abundant and diverse than previously thought, comprising at least five distinct subtypes (M1–M5). Additionally, our research has shown that ipRGCs play a role in the negative effects of light on mood and learning & memory, as well as enhancing the ability to detect contrast in images.

Position Overview

We are seeking a highly motivated and skilled Staff Scientist to join our team and contribute to our ongoing research on ipRGCs. The successful candidate will be involved in exploring the function of these cells and the neural circuits critical for ipRGC-mediated behaviors. The position offers the opportunity to work with a variety of advanced techniques, including mouse genetics, anatomy, sequencing, in-situ hybridization, in vivo calcium imaging, viral circuit tracing, and animal behavior.

Key Responsibilities:

• Conduct research focused on the detection and processing of light information by ipRGCs and their influence on brain function particularly the central pacemaker, the suprachiasmatic nucleus.
• Utilize mouse genetics and advanced imaging techniques to explore the anatomical and functional diversity of ipRGCs and the regulation of circadian rhythms.
• Collaborate with other researchers and contribute to the development of innovative methodologies to further understand ipRGC-mediated behaviors.
• Publish research findings in peer-reviewed journals and present results at scientific meetings.

Qualifications

1. Ph.D. in circadian or seasonal biology.
2. Proven experience in mouse genetics and in vivo imaging techniques.
3. Strong background in neuroanatomy, neurophysiology, circadian regulation of metabolism, feeding rhythms, and circadian behavior analysis.
4. Extensive knowledge of chronobiology with over 10 years of experience in the field, including work with photoperiodism and phase response curves.
5. Proficiency in molecular biology techniques and single nucleus sequencing of complex mammalian brains.
6. Experience in analyzing sequencing data and conducting circadian behavior analysis.
7. Excellent analytical, problem-solving, and communication skills.
8. Ability to work independently and collaboratively within a diverse multidisciplinary team.

Benefits

Salary will be commensurate with experience. A full civil service package of benefits  may be available.

How to Apply

Appointees may be a US citizen, Legal Permanent Resident or non-US citizen who are eligible for a valid work authorization. The position is subject to a background check. Interested candidates must submit a current curriculum vitae, a statement of research background and interests, and three letters of recommendation via e-mail to NIMHIRPSearch@nih.gov. Place “Staff Scientist 1 - Section on Light and Circadian Rhythm” in the subject line of your application. Applications will be accepted until the position is filled.

HHS and NIH are Equal Opportunity Employers

DHHS, NIH, and the NIMH is dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, persons from underrepresented groups, and persons with disabilities are strongly encouraged.