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News and Multimedia from 2013 Featuring DNBBS

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Streamlined Method Offers Shortcut to Generating Neurons for Discovery

Science Update

Researchers have found a shortcut to rapidly convert induced human stem cells into healthy neurons for “disease-in-a-dish” discovery – and, ultimately, personalized medicine.

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Stray Prenatal Gene Network Suspected in Schizophrenia

Press Release

Researchers have reverse-engineered the outlines of a disrupted prenatal gene network in schizophrenia, by tracing spontaneous mutations to where and when they likely cause damage in the brain.

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Bullying Exerts Psychiatric Effects Into Adulthood

Science Update

Once considered a childhood rite of passage, bullying lingers well into adulthood. Bullies and victims alike are at risk for psychiatric problems such as anxiety, depression, substance abuse, and suicide when they become adults, reported a study partially funded by the National Institute of Mental Health (NIMH) that was published in the April issue of JAMA Psychiatry.

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Ketamine Cousin Rapidly Lifts Depression Without Side Effects

Science Update

NMDA or glutamate receptor modulators as antidepressants have come of age. Human clinical studies demonstrated that ketamine can ward off depressive symptoms within 2 hours of administration and last for several days. Yet serious side effects are attached to this drug, including excessive sleepiness, hallucinations, and substance abuse behavior.

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Taming Suspect Gene Reverses Schizophrenia-like Abnormalities in Mice

Press Release

Scientists have reversed behavioral and brain abnormalities in adult mice that resemble some features of schizophrenia, by restoring normal expression to the gene Neuregulin1, which makes a protein important for brain development.

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Suppressing Protein May Stem Alzheimer’s Disease Process

Press Release

Scientists funded by the National Institutes of Health have discovered a potential strategy for developing treatments to stem the disease process in Alzheimer’s disease, by blocking activity of a little-known regulator protein called CD33.

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Video.
Dr. Michelle Freund, NIMH Project Officer on the significance of CLARITY

Project officer Michelle Freund, Ph.D., of the NIMH Division of Neuroscience and Basic Behavioral Science, explains the significance of CLARITY, a breakthrough method for analyzing the brain.

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Fat-free See-through Brain Bares All

Press Release

Scientists can now study the brain’s finer workings, while preserving its 3-D structure and integrity of its circuitry using a breakthrough method, called CLARITY, that substitutes a clear gel for fat that normally holds the brain’s working components in place, making its normally opaque and impenetrable tissue see-through and permeable.

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Developing Male Brain Exposed to Less Stress-Protective Protein

Science Update

Why are rates of schizophrenia and autism higher in males? New evidence implicates an enzyme expressed in the placenta that helps protect the developing fetal brain from adverse effects of maternal stress early in pregnancy.

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Five Major Mental Disorders Share Genetic Roots

Science Update

Five major mental disorders share some of the same genetic risk factors, the largest genome-wide study of its kind has found.

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Different Genes, Same Risk Pathway in Schizophrenia

Science Update

Work by NIMH-supported scientists illustrates the variability of the genes and biology underlying illnesses like schizophrenia.

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