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Immunofluorescent stained neurons, astrocytes, and cell nuclei in hippocampal CA3 region of brain

NIH BRAIN Initiative Tool May Transform How Scientists Study Brain Structure and Function

April 17, 2019 • Press Release

Researchers have developed a high-tech support system that can keep a large mammalian brain from rapidly decomposing in the hours after death, enabling study of certain molecular and cellular functions.

Images of dendritic spine remodeling. Images taken at baseline, after exposure to a stressor (Chronic CORT), and after a single dose of ketamine. Credit: Reprinted with permission from Conor Liston, Science (2019)

Ketamine Reverses Neural Changes Underlying Depression-Related Behaviors in Mice

April 11, 2019 • Press Release

Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice — findings that may help researchers develop interventions that promote lasting remission of depression in humans.

An illustration of molecules discovered using the mega docking library.

Mega Docking Library Poised to Speed Drug Discovery

February 6, 2019 • Press Release

Researchers have launched an ultra-large virtual docking library expected to grow to more than 1 billion molecules by next year. It will expand by 1000-fold the number of such “make-on-demand” compounds readily available to scientists for chemical biology and drug discovery.

fear lab trainees with poster at SFN 2018

Puerto Rico’s “Fear Lab” Mentors Neuroscience Rigor amid Diversity

January 30, 2019 • Press Release

A lineage of young neuroscientists from diverse backgrounds trace their scientific roots to a “fear lab” in Puerto Rico that the National Institutes of Health has been supporting for two decades.

A heatmap shows the amount of time a mouse spent in locations of an open field chamber during optogenetic stimulation of the cerebellar input to the VTA.

New Findings Reveal Surprising Role of the Cerebellum in Reward and Social Behaviors

January 17, 2019 • Press Release

A new study in rodents has demonstrated, for the first time, that the brain’s cerebellum plays a role in controlling reward and social preference behavior—findings that shed light on the brain circuits critical to the affective and social dysfunction seen across multiple psychiatric disorders.

video screenshot of Frances Johnson, NIMH trainee

Diversity Training Programs Nurture Research Career

November 14, 2018 • Science Update

A trainee tells her story of how NIMH/NIH training programs for members of underrepresented groups have nurtured her scientific career.

NIH BRAIN Initiative Debuts Cell Census of Mouse Motor Cortex – for Starters

November 1, 2018 • Press Release

NIH BRAIN Initiative Cell Census Network (BICCN) has debuted its first data release, which focuses on motor cortex. In a related development, researchers have discovered cellular secrets of key social behaviors – mating, parenting, and aggression – in mouse hypothalamus.

Molecular Secrets Revealed: Antipsychotic Docked in its Receptor

January 29, 2018 • Press Release

Scientists have deciphered the molecular structure of a widely-prescribed antipsychotic docked in its key human brain receptor. The discovery may hold clues to designing better treatments for schizophrenia, bipolar disorder and other mental illnesses.