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Recent News and Multimedia Featuring DNBBS

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NIH Completes Atlas of Human DNA Differences that Influence Gene Expression

Science Update

NIH researchers have completed an atlas documenting how DNA influence human gene expression.

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Depression’s “Transcriptional Signatures” Differ in Men vs. Women

Science Update

Brain gene expression associated with depression differed markedly between men and women. Such divergent “transcriptional signatures” may signal divergent underlying illness processes requiring sex-specific treatments.

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Scientists Give Star Treatment to Lesser-Known Cells Crucial for Brain Development

Press Release

Star-shaped support brain cells, astrocytes, growing in 3-D “organoids” in a dish develop similarly as those in human brain tissue.

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Patient-Derived Support Cells Stunt Mouse Brain Development

Science Update

Support cells generated from patients with childhood onset schizophrenia stunted neural circuit development when grafted into developing mouse brains.

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NIH Names Winners of “Follow that Cell” Phase 2 Competition

Press Release

Two biological engineering researchers are winners in Phase 2 of NIH’s Follow that Cell Challenge. The winners will share $400,000 in prizes awarded for development of new tools and methods for predicting the behavior and function of a single cell in complex tissue over time – and how that reflects the health of the tissue.

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Brain Circuit Tweak Wins Her Affection (if she’s a vole)

Science Update

For the first time, neuroscientists have boosted a female rodent’s partnering with a male by stimulating connectivity of a brain reward circuit. Understanding the circuitry of such affiliative behaviors may lead to improved treatments for social impairment in severe mental disorders, such as autism spectrum disorder.

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Brain “Relay” Also Key to Holding Thoughts in Mind

Press Release

Long overlooked as a mere “relay,” an egg-like structure in the middle of the brain also turns out to play a pivotal role in tuning-up thinking circuity. A trio of studies in mice are revealing that the thalamus sustains the ability to distinguish categories and hold thoughts in mind. It might even become a target for interventions for psychiatric disorders marked by working memory problems, such as schizophrenia.

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Human Forebrain Circuits Under Construction – in a Dish

Press Release

Neuroscientists have created a 3D window into the human brain’s budding executive hub assembling itself during a critical period in prenatal development.

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Video.
Human Forebrain Circuits Wiring-up - in a Dish

Neuroscientists have created a 3D window into the human brain’s budding executive hub assembling itself during a critical period in prenatal development.

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Sleep May Trim Neural Connections to Restore Learning Ability

Science Update

Sleep may be the price we pay for the ability to learn. It streamlines neural connections for optimal efficiency.

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