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Chemical Optimization Resource Program

This Program supports research aimed at the development of probes for the study of basic neurobiology and to support therapeutics development for mental disorders. Research areas include the discovery and optimization of in vivo chemical probes for novel CNS targets (PAR-14-279 ), and the development and testing of neuroimaging agents for targets implicated in mental illness (PAR-16-266 ). The program also supports drug discovery and optimization projects through the NIH Blueprint Neurotherapeutics Program , which provides projects with a coordinated set of grant, contract, and consultant resources to move new therapeutics toward clinical development.

It is recommended that applicants review the NIH/NIMH Therapeutics Discovery Research webpage for relevant announcements and guidance.

Applicants are strongly encouraged to discuss their proposals with the Institute contact listed below prior to the submission of their application to ascertain that their proposed work is aligned with NIMH funding priorities.


Enrique Michelotti, Ph.D.
6001 Executive Boulevard, Room 7179, MSC 9645