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Progress for Goal 1
Learn about the progress NIMH has made toward Goal 1 of the NIMH Strategic Plan for Research: Define the Brain Mechanisms Underlying Complex Behavior.
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Andrea Beckel-Mitchener, Ph.D., has been named deputy director of the trans-NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative.
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A study of spatial learning in mice shows that exposure to new experiences dampens established representations in the brain’s hippocampus and prefrontal cortex, allowing the mice to learn new navigation strategies.
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A new study conducted by researchers at NIMH suggests that differences in the expression of gene transcripts – readouts copied from DNA that help maintain and build our cells – may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns of onset, symptoms, course of illness, and treatment responses.
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A genetic study has identified neuronal abnormalities in the electrical activity of cortical cells derived from people with a rare genetic disorder called 22q11.2 deletion syndrome.
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The need to identify effective targets for intervention in anorexia nervosa is pressing, as patient outcomes are often poor. An NIMH-funded genome-wide association study suggests that metabolic processes may play an important role in the disorder, offering a promising new avenue for investigation.
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A scientific analysis of more than 2,000 brain scans found evidence for highly reproducible sex differences in the volume of certain regions in the human brain.
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Researchers funded by NIMH have found that astrocytes, a type of brain cell, can harbor HIV and then spread the virus to immune cells that traffic out of the brain and into other organs.
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In a study published in 2019 in the journal Nature Neuroscience, researchers funded by the National Institute of Mental Health investigated the neurobiological changes that occur in the brain circuits of mice when contextual fear memories — fear of a place where an aversive event occurred — are formed and extinguished.
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Researchers were able to identify different types of rare genetic variations associated with autism spectrum disorder by analyzing data shared via the NIMH-funded Autism Sequencing Consortium.
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