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Cognitive Training Resource Exchange (CogTRex)

NAMHC Concept Clearance


Ann Wagner, Ph.D.
Chief, Neurobehavioral Mechanisms of Mental Disorders Branch
Division of Developmental Translational Research (DDTR)


This initiative aims to create an online sharing site for researchers who are developing and testing the efficacy of cognitive training (CT) interventions for mental disorders. The CogTREx website would promote sharing of resources and information across disciplines and among researchers, addressing a range of mental disorders in children and adults. CogTREx aims to accelerate intervention development through early sharing of successes and failures, to promote rigorous clinical trial design, and to promote interaction across disciplines and disorders.


On April 9-10, 2012, NIMH sponsored a meeting of experts in CT, to review the current state of evidence for efficacy of CT approaches, discuss interventions currently in development, identify challenges to this line of research and research gaps, and learn of efforts to adopt CT interventions in clinical practice. The overarching theme of the presentations and discussions was the potential for CT approaches to add to the catalog of evidence-based treatments for people with mental disorders. Meeting participants expressed optimism that one day we may be able to identify the key neural system impairments unique to individual patients, and prescribe personalized programs of CT to target those impairments. Much of this work is still exploratory, and most interventions are in early stages of development. Given the rapid proliferation of new and adapted CT approaches, and the need for rigorous testing, investigators expressed enthusiasm for opportunities to share experiences and resources.

This initiative aims to create an online site for the exchange of information and tools, developed in collaboration with, and accessible to, researchers engaged in the development and testing of CT interventions. The site may include a registry of studies, searchable on key study elements (e.g., age, diagnosis, domains of functioning, circuits targeted); assessment tools, forms, procedures, and associated data dictionaries; and, publications and meeting abstracts resulting from studies, including negative results. CogTREx aims to facilitate the more rapid translation of emerging findings on the neuroscience of mental disorders into interventions targeting the neural impairments underlying mental disorders.

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