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Eating Disorders

Featured Studies

Featured studies include only those currently recruiting participants. Studies with the most recent start date appear first.

  • Target Engagement of a Novel Dissonance-Based Treatment for DSM-5 Eating Disorders
    Study Type: Observational
    Start Date: July 10, 2017
    Locations: Eugene, Oregon; Austin, Texas
    Eligibility: Females, Ages 18–34, Does Not Accept Healthy Volunteers

    Most people with an eating disorder (ED) do not receive good treatment. The investigators have developed a new brief group treatment that is supposed to work by reducing how much women with an ED value the impossible thinness standard promoted by the media and how much they value/crave binge foods. The investigators want to test whether the treatment actually changes those two mechanisms using brain scan data, which is more objective than completing questionnaires and even interviews.

    In the first phase of the study (R61), the investigators will compare women in the treatment versus those on a wait-list. If the investigators can show that the treatment "works" (does what the investigators think it does) compared to no active treatment (women will be allowed to seek and receive outside help but investigators will not provide it until after the wait-list), investigators will conduct the second phase of study (R33),where they will randomly assign women with an ED to either the new treatment or to a group treatment that represents what many college mental health clinics provide to their clients with ED.

  • Reward Systems and Food Avoidance in Eating Disorders
    Study Type: Interventional
    Start Date: November 1, 2016
    Location: New York, New York
    Eligibility: Females, Ages 12–18, Accepts Healthy Volunteers

    The researchers plan to explore brain networks involved in emotion processing and learning using a brain scan and test meals. One core feature of Anorexia Nervosa (AN) is eating a small number of high-calorie or high-fat foods. By studying why individuals with AN are disgusted by food or other eating situations, the researchers will be able to understand more about the neurobiological pathways that lead to restricting food intake and food avoidance. This study also aims to find whether one of two short-term interventions (Interoceptive Exposure (IE); Family-Based Therapy (FBT)) affects connections in the brain and if the treatments affect food avoidance. IE is an intervention that helps reduce anxiety about eating. FBT is an intervention that motivates patients to eat through working with family to increase the value of eating and decrease the value of avoiding foods.

  • Neural Bases of Multiple Forms of Self-regulatory Control in Bulimia Nervosa
    Study Type: Observational
    Start Date: June 1, 2016
    Location: San Diego, California
    Eligibility: Females, Ages 18–35, Accepts Healthy Volunteers

    The purpose of this study is to investigate areas of the brain responsible for self-regulation in adult women who have never had an eating disorder with women who have bulimia nervosa. More specifically, investigators are interested in changes in brain activation (e.g., changes in blood flow and oxygen use) when inhibiting responses and regulating emotions. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

  • Microbiome-mediated Weight, Anxiety, and Stress Dysregulation in Anorexia Nervosa
    Study Type: Observational
    Start Date: April 1, 2016
    Location: Chapel Hill, North Carolina
    Eligibility: Females, Ages 15–45, Accepts Healthy Volunteers

    The purpose of this research study is to analyze the microorganisms residing in the gut of patients with anorexia nervosa. Research has begun to link changes in the intestinal microbiota with diseases such as inflammatory bowel disease (IBS), asthma, and obesity, but although some studies have investigated the intestinal microbiota in overweight/obese individuals, very little is known about the intestinal microbiota in underweight individuals. The investigators aim to identify the enteric bacterial groups associated with adiposity, BMI, anxiety, and stress in patients with anorexia nervosa.

  • Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa
    Study Type: Interventional
    Start Date: October 1, 2015
    Location: Tulsa, Oklahoma
    Eligibility: Ages 18–55, Accepts Healthy Volunteers

    This study aims to identify the brain regions responsible for encoding cardiorespiratory 'interoceptive' sensations and determine whether they are dysfunctional in individuals affected by eating disorders, anxiety, depression, or brain injury. By evaluating the same interoceptive sensations across different human illnesses, the investigators hope to provide convergent evidence resulting in identification of core underlying neural processes, and to discern relative contributions in each condition.

  • Improving Treatments for Bulimia Nervosa: Innovation in Psychological Interventions for Regulating Eating
    Study Type: Interventional
    Start Date: May 1, 2015
    Location: Philadelphia, Pennsylvania
    Eligibility: Ages 18 and Older, Does Not Accept Healthy Volunteers

    The purpose of the study is to test a novel, acceptance-based behavioral treatment for bulimia nervosa (BN) in adults. This treatment is a type of individual psychotherapy called Nutritional Counseling And Acceptance-Based Therapy (N-CAAT) that enhances existing cognitive behavioral therapy (CBT) for BN by incorporating acceptance-based behavioral strategies and nutritional counseling to help patients eliminate BN symptoms.