Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
- PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome.
Interventional study. Background: McCune-Albright Syndrome (MAS) is a disorder that affects the bones, skin, and some hormone-producing tissues. Ages 18-100. Location in Bethesda, MD.
- Checking Out Checking In: The Development and Validation of an Electronic Screening Tool for Pediatric Psychosocial Distress.
Evaluation study. Background: - Medical problems and treatments can cause stress in some people. Ages 8-21. Location in Bethesda, MD.
- Imaging and Genetic Investigation of Learning and Decision Making.
Evaluation study. Background: - Previous research has shown that dopamine, a brain chemical, is involved in decision making. Ages 18-55. Location in Bethesda, MD.
- Brain Stimulation and Vision Testing.
Evaluation study. Background: - The brain has two systems for recognizing objects. Ages 18-50. Location in Bethesda, MD.
- Translocator Protein and Inflammation After Traumatic Brain Injury.
Interventional study. Background: - People with traumatic brain injury (TBI) often have inflammation in the brain. Ages 18-70. Location in Bethesda, MD.
- Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle.
Evaluation study. Background: - Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. Ages 18-65. Location in Bethesda, MD.
- Defining the Brain Phenotype of Children With Williams Syndrome.
Evaluation study. Background: - Little is known about how the brain changes during childhood and adolescence, how genes affect this process, or how the brains of people with Williams syndrome change during this period. Ages 5-55. Location in Bethesda, MD.
- Top-Down Attentional Control of Visual-Processing.
Evaluation study. Background: - Previous studies have shown that people with certain types of brain damage may have particular problems paying attention and processing things that they see. Ages 18 and over. Location in Bethesda, MD.
- Characterizing Lone Parenting: A Multi-institutional Pilot Study of the Perceptions of Support and Perceived Stress of Lone Parents of Children With Cancer.
Evaluation study. This study will describe the perceptions of support and distress outcomes of single/lone parents of a child with cancer. Ages 18-65.
- Regional Rates of Cerebral Protein Synthesis: Effects of Sleep and Memory Consolidation.
Evaluation study. Background: - The brain needs sleep to function normally, but the purpose of sleep is not understood. Ages 18-28. Location in Bethesda, MD.
- Mirror Therapy for Phantom Limb Pain.
Evaluation study. This study, conducted at the National Institutes of Health (NIH) and at Walter Reed Army Medical Center (WRAMC), will explore the phenomenon of phantom limb pain (a continued feeling of pain in an amputated limb) and will use functional magnetic resonance imaging (fMRI) to investigate the effect of mirror therapy on phantom limb pain. Ages 18-75. Locations in Washington, DC; Bethesda, MD.
- Protein Synthesis in the Brain of Patients With Fragile X Syndrome.
Evaluation study. Biosynthesis of proteins is essential for growth and continued maintenance of the entire neuron including axons, dendrites, and synaptic terminals, and it is clearly one of the important biochemical processes underlying adaptive changes in the nervous system. Ages 18-24. Location in Bethesda, MD.
- MRS Measurement of Glutamate and GABA Metabolism in Brain.
Interventional study. This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of C as it is naturally metabolized from glucose to specific chemical transmitters. Ages 18-65. Location in Bethesda, MD.
- PET Scanning in Parkinson s Disease.
Evaluation study. This is an in vivo positron emission tomography (PET) study of regional cerebral dopamine and blood flow in normal volunteers, persons with Parkinson s disease (both familial and sporadic), and those with schizophrenia spectrum disorders. Ages 18 and over. Location in Bethesda, MD.
- Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers.
Evaluation study. The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers. Ages 18 and over. Location in Bethesda, MD.
- Studies of Blood Flow to the Brain During Thought.
Evaluation study. The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks. Ages 18-65. Location in Bethesda, MD.
- The Effects of Reproductive Hormones on Mood and Behavior.
Evaluation study. This study evaluates the effects of estrogen and progesterone on mood, the stress response, and brain function in healthy women. Ages 18-50. Location in Bethesda, MD.